A5009249225- Cancer Cells and Metastasis
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pluripotent Stem Cells Research
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- TGF-β signaling in diseases
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal disorders and treatments
CHA University
2016-2025
CHA Bundang Medical Center
2016-2025
Gyeongsang National University
2016
University of Michigan
2011-2015
CHA Gangnam Medical Center
2011
The stimulator of IFN genes (STING) signaling pathway is a critical link between innate and adaptive immunity induces antitumor immune responses. STING expressed in vasculatures, but its role tumor angiogenesis has not been elucidated. Here, we investigated STING-induced vascular remodeling the potential STING-based combination immunotherapy. Endothelial expression was correlated with enhanced T cell infiltration prolonged survival human colon breast cancer. Intratumoral activation agonists...
Developmental pathways such as Notch play a pivotal role in tissue-specific stem cell self-renewal well tumor development. However, the of signaling breast cancer cells (CSC) remains to be determined. We utilized lentiviral reporter system identify subset with higher activity (Notch(+)) or reduced (Notch(-)) multiple lines. Using vitro and mouse xenotransplantation assays, we investigated pathway CSC regulation. Breast increased displayed sphere formation expression markers. Interestingly...
Kim T H, Y K, Kwon Y, Heo J Kang G & An H (2010) Histopathology 57 , 734–743 Deregulation of miR‐519a, 153, and 485‐5p its clinicopathological relevance in ovarian epithelial tumours Aims: The pathological clinical significance aberrant miRNA expression has yet to be adequately documented. aim this study was assess the differences human according histological subtype, determine whether miRNAs are potential diagnostic prognostic markers cancers. Method results: profiles 103 were...
Background: Stimulator of Interferon Genes (STING) is an innate immune sensor for cytosolic DNA.STING signaling activation indispensable type I interferon response and the anti-cancer by CD8 + T cells.The aim this study was to characterize intratumoral STING expression pattern its clinical implication in colorectal cancer (CRC).Methods: We analyzed 225 CRC patients who underwent surgical resection.Clinicopathological variables survival outcomes were according levels.Mice with syngeneic MC38...
Notch signaling plays an important role in ovarian cancer chemoresistance, which is responsible for recurrence. Gamma‐secretase inhibitor (GSI) a broad‐spectrum inhibitor, but it has serious side effects. The efficacy of Notch3‐specific inhibition paclitaxel‐resistant cancers was assessed this study, not yet been evaluated relative to GSI. To analyze the effect on cancers, we compared cell viability, apoptosis, migration, angiogenesis, cycle, and spheroid formation after treatment with...
Notch signalling plays diverse roles in malignant tumours as well normal tissue development. In this study we investigated the expression of pathway genes and their clinicopathological significance gastric carcinomas.Notch1, Notch3, Jagged1, Jagged2 Hes1 were analysed by quantitative real-time polymerase chain reaction (qRT-PCR) (n = 81) immunohistochemistry 103) carcinomas. MUC2 MUC5AC also assessed, using only. With qRT-PCR, Notch1, Jagged1 increased significantly tumour compared to (P <...
Lefty expression has been recognized as a stemness marker because is enriched both in undifferentiated embryonic stem cells (ESCs) and blastocysts. Here, we examined the function of Lefty1 Lefty2 maintenance self-renewal pluripotency mouse ESCs (mESCs). Suppression or mESCs did not alter properties under nondifferentiating conditions, but suppression these genes affect Smad2 phosphorylation differentiation. knockdown showed enhanced increased differentiation potential, whereas exhibited...
Tumor recurrence by obtaining chemoresistance is a major obstacle to treating ovarian cancer. By TargetScan database and luciferase reporter assay, we identified miR-150 directly targets Notch3, which key oncogene in We, therefore, investigated the role of cancer cells, usefulness as therapeutic target chemoresistant cancer, through examining expression qRT-PCR cell lines tissues, assessing gain-of-function effect WST, colony forming, TUNEL, wound healing angiogenesis assays. Western...
Small cell lung cancer (SCLC) is the leading cause of death, with a high propensity for aggressiveness and metastasis even in an early stage. Thus, identification biomarkers as diagnostics treatment needed. In this study, we investigated differentially regulated proteins between human SCLC tissues normal bronchial epithelium by proteomic analysis using two-dimensional electrophoresis (2-DE) MALDI-TOF mass spectrometry. Seven protein isoforms, including, γ-actin, tubulin α-1B, laminin B1,...
IgG4-related disease (IgG4-RD) is an autoimmune condition marked by IgG4-positive plasma cell infiltration, causing inflammation, fibrosis, and tumor-like lesions, especially in the lacrimal gland (LG). Current diagnostic criteria, based primarily on serum IgG4 levels, face limitations predicting clinical outcomes treatment responses. To address this, we conducted a multiplex immaunohistochemical analysis of LG tissues to assess immune checkpoint interactions distribution relation mass size,...
Ovarian carcinoma is a highly lethal malignancy due to frequent relapse and drug resistance. Cancer stem cells (CSCs) are thought contribute significantly disease In this study, subpopulation of CSCs ovarian was isolated the genes differentially expressed in these were identified characterize find candidate biomarkers. from patients primarily cultured, spheroid-forming (SFCs) isolated. The characteristic SFCs through cDNA microarray validation by quantitative real-time polymerase chain...
Intestinal fibrosis is a serious complication of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. There no specific treatment for intestinal fibrosis. Studies have indicated that peroxisome proliferator-activated receptor- γ (PPAR-γ) agonists anti-fibrogenic properties in organs besides the gut; however, their effects on human are poorly understood. This study investigated mechanisms PPAR-γ primary myofibroblasts (HIFs). HIFs were isolated from normal colonic...
Ovarian cancer is one of the leading causes deaths among patients with gynecological malignancies worldwide. In order to identify prognostic markers for ovarian cancer, we performed RNA-sequencing and analyzed transcriptome data from 51 who received conventional therapies high-grade serous carcinoma (HGSC). Patients early-stage (I or II) HGSC exhibited higher immune gene expression than advanced stage (III IV) HGSC. predict prognosis HGSC, created machine learning-based models identified...
Alteration in expression of miRNAs can cause various malignant changes and the metastatic process. Our aim was to identify involved cervical squamous cell carcinoma (SqCC) metastasis, test their utility as indicators metastasis survival. Using microarray technology, we performed miRNA profiling on primary SqCC tissue (n = 6) compared with normal control (NC) that had (SqC-M; n 3) not (SqC-NM; metastasized. Four were selected for validation by qRT-PCR 29 SqC-NM 27 SqC-M samples, nine lesions...
The principal objective of this study was to comprehensively assess the clinicopathologic and prognostic impacts expression various cell cycle regulatory proteins in patients with ovarian epithelial tumors. tissue microarrays were constructed from formalin-fixed, paraffin-embedded tissues 205 We investigated 55 benign (20 serous cystadenomas, 17 mucinous 18 endometriotic cysts), 72 borderline (26 tumors 46 tumors), 78 malignant (45 carcinomas, 10 adenocarcinomas, 15 endometrioid 8 clear...