A5071742850- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Dermatology and Skin Diseases
- Telomeres, Telomerase, and Senescence
- Hair Growth and Disorders
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Drug-Induced Adverse Reactions
- Genetic and rare skin diseases.
- Laser Applications in Dentistry and Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Melanoma and MAPK Pathways
- Psoriasis: Treatment and Pathogenesis
- Cutaneous lymphoproliferative disorders research
- Tattoo and Body Piercing Complications
- Nonmelanoma Skin Cancer Studies
- Bartonella species infections research
- Garlic and Onion Studies
- Prion Diseases and Protein Misfolding
- Microbial Metabolism and Applications
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
Ajou University
2019-2025
Ajou University Hospital
2023-2024
Abstract Melasma relapse is almost common after discontinuation of conventional treatment. Recent studies suggesting that photoaging dermis the main pathomechanism melasma, emphasize dermal targeting therapy. We investigated maintenance effect microneedling radiofrequency (RF) for melasma Subjects with were administered oral tranexamic acid and triple combination cream 2 months a randomly assigned half face was treated RF. After therapy, RF continued monthly over 6 months. Modified area...
The biological process of aging is thought to result in part from accumulation senescent cells organs. However, the present study identified a subset fibroblasts and smooth muscle which are major constituents organ stroma neither proliferative nor tissues elderly, we termed "mid-old status" cells. Upregulation pro-inflammatory genes (IL1B SAA1) downregulation anti-inflammatory (SLIT2 CXCL12) were detected mid-old In stroma, SAA1 promotes development inflammatory microenvironment via...
The human microbiome plays an important role in various diseases, including Behçet’s disease (BD). However, the effects of activity and covariates influencing microbial composition have not yet been investigated. Therefore, we investigated fecal salivary microbiomes BD patients compared to those recurrent aphthous ulcer (RAU) patients, as well dietary habit-matched healthy controls (HCs) selected from immediate family members using 16S rRNA gene sequencing. alpha diversity was different that...
Vitiligo has been considered an unexplained paradoxical phenomenon during biologics use. Herein, we report adult case of progression pre-existing vitiligo secukinumab treatment for psoriasis, and also examined the immunohistochemical changes in relation to He was being administered monthly 300 mg dose 2 years, all psoriatic lesions were cleared, but hypopigmented became more distinct larger than before unlike when using adalimumab. A skin biopsy lesion showed loss epidermal melanocytes...
Hypopigmented scars are challenging to treat, and the focus for successful treatment is cause pigment cells produce more melanin. In this study, we evaluated repigmentation effects of 0.4 mm motorized-micropunch grafting with skin-seeding hypopigmented scars. Twenty-one patients on face neck that had been resistant conventional who finally undergone micropunch a technique (SST) were retrospectively reviewed. Repigmentation outcomes global assessment by physician using 4-point scale. Adverse...
The incidence of skin cancer is increasing because the ageing population and ultraviolet exposure, previous studies have revealed that long‐term use hydrochlorothiazide (HCTZ), an antihypertensive agent, has been associated with increased risk nonmelanoma (NMSC). However, association NMSC HCTZ within East Asian populations unclear. To investigate in Korean subjects using HCTZ. A retrospective cohort study was conducted administrative healthcare data. enrolled 62 243 patients exposed to a...
Acral lentiginous melanoma (ALM) is a relatively rare clinicopathologic subtype of cutaneous malignant melanoma, but it the most common type among Asians. Although research to identify immunohistochemical (IHC) markers differentiate nevi from being conducted, specific for ALM are not well-known. Therefore, we aimed analyze and compare differences in expression melanocyte-associated IHC between acral benign (ABN). Two independent groups 53 19 paraffin-embedded specimens (from patients with...
Abstract Granulomatous rosacea (GR) is a rare and distinct variant of rosacea. We report three cases recalcitrant GR successfully treated with pulsed‐dye laser (PDL) provide experimental evidence supporting its potential as treatment option. PDL demonstrated remarkable efficacy in the clinical cases, despite their resistance to conventional therapies. Chemokine ligand 9 (CXCL9), key chemokine involved inflammation granuloma formation, was found be increased skin sections from all patients....
Abstract Objectives The pulsed dye laser (PDL) is an effective modality for preventing and improving hypertrophic scars (HSs). However, the heterogeneity of parameter settings subjective scar assessment methods used in most studies resulting uncertainty with treatment plans. Therefore, we investigated effect PDL (V‐beam; Candela Laser Corporation) on HSs post‐thyroidectomy patients using three‐dimensional imaging analysis intended to provide a systemic optimal protocol. Methods Nineteen HS...
Abstract Seborrheic keratosis (SK) is a common skin disease in the elderly. However, cases where SK presenting as multiple skin-colored or clustered lesions can be easily misdiagnosed verruca plana (VP), especially young population. This retrospective study investigated prevalence of and VP that appear clinically similar to according age. We examined pathology slides tissue photographs patients who were suspected have VP. A total 503 included study, out which 174 finally diagnosed with...
Abstract Photoaging pigmentation conditions such as senile lentigo and melasma show epidermal melanogenic activity dermal abnormalities, including collagen degradation. A rejuvenation strategy with skin‐lightening therapy directly acting on melanocytes is suggested for photoaging pigmentation. This study investigates whether biostimulation can result in skin lightening of skin. split‐face clinical trial was conducted, involving 40 subjects facial lentigo. Subjects received a poly‐DL‐lactic...
Abstract Cellular senescence, recognized as a key hallmark of aging, leads to the accumulation senescent cells in various tissues over time. While detrimental effects these on age-related pathological conditions are well-documented, there is still limited information about how distributed normal both young and aged organs. Our research indicates that fully p16 INK4A+ rarely identified parenchyma organic stromal crucial for structural maintenance, such fibroblasts smooth muscle cells....