A5003841335- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Extracellular vesicles in disease
- Ginseng Biological Effects and Applications
- Fatty Acid Research and Health
- Genomics, phytochemicals, and oxidative stress
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Bee Products Chemical Analysis
- Enzyme Production and Characterization
- Curcumin's Biomedical Applications
- Tea Polyphenols and Effects
- Advanced Nanomaterials in Catalysis
- Genetically Modified Organisms Research
- Cancer Genomics and Diagnostics
- Antioxidant Activity and Oxidative Stress
- Protein Hydrolysis and Bioactive Peptides
- Food composition and properties
- Insect and Pesticide Research
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Microbial Metabolic Engineering and Bioproduction
- Probiotics and Fermented Foods
- Agriculture, Soil, Plant Science
- Proteins in Food Systems
Dankook University
2013-2024
National Cancer Center
2015-2021
Yonsei University
2016-2020
Kyung Hee University
2010-2012
Cornell University
2007-2011
New York State Department of Agriculture and Markets
2009-2010
Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or progression. The conventional techniques for the isolation detection of face several limitations, restricting their clinical applications. Hence, a highly efficient technique identification from biological samples may provide critical information about biomarkers improve our understanding unique role...
Rosa damascena has been manufactured as various food products, including tea, in Korea. A new flavonoid glycoside, kaempferol-3-O-beta-D-glucopyranosyl(1-->4)-beta-D-xylopyranoside, named roxyloside was isolated from the buds of this plant, along with four known compounds, isoquercitrin, afzelin, cyanidin-3-O-beta-glucoside, and quercetin gentiobioside. The chemical structures these compounds were determined by spectroscopic analyses, FAB-MS, UV, IR, (1)H (13)C NMR, DEPT, 2D NMR (COSY, HSQC,...
Thurincin H, a bacteriocin produced by Bacillus thuringiensis SF361 isolated from honey, strongly inhibited the growth of cereus F4552. The was purified 65% ammonium sulfate precipitation culture supernatant, followed octyl-sepharose CL-4B and reverse-phase HPLC. molecular mass determined to be 3139.51 Da 14 amino acids at N-terminus were identified. complete acid sequence mature thurincin H deduced three structural genes, thnA1, thnA2, thnA3 found in tandem repeats on chromosome, all which...
An electroresponsive drug release system based on polypyrrole (Ppy) nanowires was developed to induce the local delivery of anticancer drug, doxorubicin (DOX), according applied electric field. DOX-conjugated Ppy nanowire (NW) (DOX/Ppy NW) array initially prepared by electrochemical deposition a mixture pyrrole monomers and biotin as dopants in anodic alumina oxide membrane sacrificial template. Morphological observation scanning electron microscopy revealed free-standing 3D...
Curcuma longa L. (turmeric) is used as a food spice; however, its strong taste restricts wider applications ingredient despite well-known health benefits. To develop an effective yet simple process for enhancing antioxidant and anti-inflammatory activities, turmeric was gun-puffed at various pressures. Puffed exhibited increase in brown color porous structures, indicating the occurrence of Maillard reaction vaporization during process. Proximal analysis revealed that puffing did not alter...
We developed an event-specific DNA microarray system to identify 19 genetically modified organisms (GMOs), including two GM soybeans (GTS-40-3-2 and A2704-12), thirteen maizes (Bt176, Bt11, MON810, MON863, NK603, GA21, T25, TC1507, Bt10, DAS59122-7, TC6275, MIR604, LY038), three canolas (GT73, MS8xRF3, T45), one cotton (LLcotton25). The included 27 oligonucleotide probes optimized endogenous reference targets, screening targets (35S promoter nos terminator), internal target (18S rRNA gene)....
삼채의 잎, 인경, 뿌리 세 부위를 물, 메탄올-물 혼합용매, 무수 메탄올을 이용하여 추출물을 제조한 후, 총페놀 함량, 총플라보노이드 함량 및 항산화능을 정량 분석하였다. 부위별 함량은 잎이 240.4-276.6 mg GAE/100 g FW, 인경이 65.5-82.8 뿌리가 50.0-59.4 FW를 보였다. 잎에서 9.7-34.1 CE/100 인경에서 5.0-16.7 뿌리에서는 4.4-15.3 FW로 나타났다. ABTS법, DPPH법, ORAC법을 통한 항산화능은 각각 78.7-103.4, 24.4-59.0, 1,798.8-2,169.7 VCE/100 인경에서는 35.8-51.1, 9.3-26.3, 415.3-611.7 42.0-55.9, 12.8-24.4, 291.7-429.4 FW을 삼채 중에서 가장 높은 가졌다. 6가지 추출용매에서 60% (v/v) 혼합용매에서 주로 활성을 나타냈다. 함량보다 함량과 더 상관관계를 본 연구의 결과는 삼채가 항산화능 공급할 수 있는...
Halocynthia aurantium, an edible ascidian species, has not been studied scientifically, even though tunicates and ascidians are well-known to contain several unique biologically active materials. The current study investigated the fatty acid profiles of H. aurantium tunic its immune-regulatory effects on RAW264.7 macrophage cells. Results profile analysis showed a difference in ratios, depending acids being analysed, including those saturated (SFA), monounsaturated (MUFA), polyunsaturated...
Abstract: Phenolics in dry Artemisia princeps Pampanini, an herbal plant traditionally consumed as food ingredients Korea was extracted, fractionated, and quantified well evaluated for its neuroprotection PC‐12 cells. Whole extract had 5,852 mg gallic acid equivalents/100 g of total phenolics 6,274 9,698 vitamin C antioxidant capacities assayed by DPPH ABTS radicals, respectively. The fraction extracted with n ‐butanol the highest levels capacity than other fractions ( ‐hexane, chloroform,...
Circulating cell-free DNA (cfDNA) is currently recognized as a key non-invasive biomarker for cancer diagnosis and progression therapeutic efficacy monitoring.Because cfDNA has been detected in patients with diverse types of cancers, the use efficient strategies to isolate not only provides valuable insights into tumour biology, but also offers potential developing new cancer-specific targets.However, challenges associated conventional extraction methods prevent their further clinical...
Turmeric (
This study was performed to characterize the CLA production ability of a bacterial strain, Bifidobacterium breve LMC 520, which can actively convert linoleic acid (LA) cis-9,trans-11 conjugated (CLA), major isomer derived from microbial enzymatic conversion. The culture conditions were optimized improve under aerobic conditions. B. 520 tested with different amounts LA in varied conditions, such as air, additives, and pH. A maximal level (up 90% substrate) obtained after 24 h incubation...
The effects of puffing on ginsenosides content and antioxidant activities American Canadian ginsengs, Panax quinquefolius, were investigated. ginsengs puffed at different pressures extracted using 70% ethanol. Puffing formed a porous structure, inducing the efficient elution internal compounds that resulted in significant increases extraction yields crude saponin content. minor (Rg2, Rg3, compound K) increased with increasing pressure, whereas major (Rg1, Re, Rf, Rb1, Rc, Rd) decreased,...
Abstract Extracellular vesicles (EV) in the tumor microenvironment have emerged as crucial mediators that promote proliferation, metastasis, and chemoresistance. However, role of circulating small EVs (csEV) cancer progression remains poorly understood. In this study, we report csEV facilitate determine its molecular mechanism. csEVs strongly promoted migration cells via interaction with phosphatidylserine csEVs. Among three TAM receptors, TYRO3, AXL, MerTK, TYRO3 mainly interacted...
Circulating tumor-specific markers are crucial to understand the molecular and cellular processes underlying cancer, develop therapeutic strategies for treatment of disease in clinical applications. Many approaches isolate analyze these have been reported. Here, we propose a straightforward method highly efficient capture release exosomes circulating tumor cells (CTCs) single platform with well-ordered three-dimensional (3D) architecture that is constructed using simple electrochemical...