A5101774596- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Plant-derived Lignans Synthesis and Bioactivity
- Bioactive natural compounds
- Phytochemistry and Bioactive Compounds
- Magnolia and Illicium research
- Metabolomics and Mass Spectrometry Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional and Medicinal Uses of Annonaceae
- Fungal Biology and Applications
- Antioxidant Activity and Oxidative Stress
- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Biological and pharmacological studies of plants
- Free Radicals and Antioxidants
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Polysaccharides and Plant Cell Walls
Kyungpook National University
2024-2025
Rural Development Administration
2015-2024
Incheon National University
2024
AtoGen (South Korea)
2021-2023
Bridge University
2021
Wonkwang University
2021
Yanbian University
2021
Kwangwoon University
2021
Kyung Hee University
2007-2020
Korea University
2020
The effective production and usage of ginsenosides, given their distinct pharmacological effects, are receiving increasing amounts attention. As the ginsenosides content differs in different parts Panax ginseng, we wanted to assess compare ginseng roots, leave, stems, berries. To extract 70% (v/v) methanol was used. optimal ultra-performance liquid chromatography-quadrupole time flight mass spectrometry (UPLC-QTOF/MS) method used profile various from P. ginseng. datasets were then subjected...
<italic>Lactobacillus plantarum</italic> HAC01 ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced diabetic mice association with modulating the gut microbiota.
As a direct write technology, the electrohydrodynamic printing of silver nanoparticles by using focused nanocolloid jet is introduced. In this letter, two categorized types examples two-dimensional patterning were printed method. A spiral-type inductor was to demonstrate feasibility as fabrication process. The spiral produced 9.45μH and exhibited approximately five times larger resistivity (9.5μΩcm) than that bulk after sintering Then, complex geometries having square- round-shape patterns...
Rosa damascena has been manufactured as various food products, including tea, in Korea. A new flavonoid glycoside, kaempferol-3-O-beta-D-glucopyranosyl(1-->4)-beta-D-xylopyranoside, named roxyloside was isolated from the buds of this plant, along with four known compounds, isoquercitrin, afzelin, cyanidin-3-O-beta-glucoside, and quercetin gentiobioside. The chemical structures these compounds were determined by spectroscopic analyses, FAB-MS, UV, IR, (1)H (13)C NMR, DEPT, 2D NMR (COSY, HSQC,...
Fabrication of a flexible organic solar cell is demonstrated with an anode that free tin-doped indium oxide (ITO) by electrohydrodynamic (EHD) spraying silver nanowires (Ag NWs). This methodology applicable to fabricate patterned Ag NW thin-film electrodes for cells (OSCs). By optimizing the spray parameters and post-processing conditions, transparent sheet resistances ∼11 Ω sq−1 (on glass) ∼20 polyethylene terephthalate, PET) DC optical conductivities ∼70 can be obtained at transmittance...
Triterpenoid saponins (TSs) are common plant defense phytochemicals with potential pharmaceutical properties. Platycodon grandiflorus (Campanulaceae) has been traditionally used to treat bronchitis and asthma in East Asia. The oleanane-type TSs, platycosides, a major component of the P. root extract. Recent studies show that platycosides exhibit anti-inflammatory, antiobesity, anticancer, antiviral, antiallergy However, evolutionary history platycoside biosynthesis genes remains unknown. In...
A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, I (2), II (3), isoastragaloside (4) astragaloside IV (5)...
A prenylated arylbenzofuran and six flavonoids were isolated from the fruits of Morus alba L. through silica gel, octadecyl Diaion HP-20 column chromatography. Based on nuclear magnetic resonance, mass spectrometry, infrared spectroscopic data, chemical structures compounds determined to be artoindonesianin O (1), isobavachalcone (2), morachalcone (3), quercetin (4), astragalin (5), isoquercetin (6), rutin (7). The evaluated for protection HT22-immortalized hippocampal cells against...
Shikonin (SKN), a highly liposoluble naphthoquinone pigment isolated from the roots of Lithospermum erythrorhizon , is known to exert antibacterial, wound-healing, anti-inflammatory, antithrombotic, and antitumor effects. The aim this study was examine SKN antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). analyzed in combination with membrane-permeabilizing agents Tris Triton X-100, ATPase inhibitors sodium azide N,N ′-dicyclohexylcarbodiimide, S. -derived...
Brazilin, isolated from the methanol extract of heart wood Caesalpinia sappan, sensitizes cancer cells to apoptosis. Glioblastoma multiforme (GBM), which accounts for most cases central nervous system malignancy, has a very poor prognosis and lacks effective therapeutic interventions. We, therefore, investigated effects different concentrations periods exposure brazilin on cell proliferation apoptosis in glioma U87 line. Cell was by MTT assays growth curve analysis, assessed FACS analysis...
Panax ginseng has long been used as natural medicine and health food all over the world. Cancer is a major cause of death worldwide its prognosis likely depends on immune system during tumor treatment. In this study, berry polysaccharides were evaluated for their immunostimulant anti-cancer effects. Ginseng polysaccharide portion (GBPP) was to investigate effects anti-complementary activity, peritoneal macrophage activation, killer (NK) cell cytotoxicity. Moreover, both intravenous (i.v.)...
In the food industry and herbal markets, it is critical to control quality of processed Panax ginseng products. this study, ultra-performance liquid chromatography coupled quadrupole time flight mass spectrometry (UPLC-QTOF/MS)-based metabolomics was applied for evaluation white (WG), tae-geuk (TG), red (RG), black (BG). Diverse metabolites including ginsenosides were profiled by UPLC-QTOF/MS, datasets WG, TG, RG, BG then subjected multivariate analyses. principal component analysis (PCA),...
Centella asiatica (L.) Urban contains two ursane-type triterpene saponins, asiaticoside and madecassoside, as major secondary metabolites. In order to select candidate genes encoding UDP-glucosyltransferases (UGTs) involved in biosynthesis, we performed transcriptomic analysis of leaves elicited by methyl jasmonate (MeJA). Among the unigenes, 120 isotigs 13 singletons unique sequences were annotated UGTs, including 37 putative full-length cDNAs, 15 UGT named according committee nomenclature...
The effects of black ginseng, which has many kinds biological activities, on dogs was investigated. Serum samples beagle dogs, were fed with ginseng for 8 weeks, measured using high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectrometry. Acquired NMR data from the serum 0, 4, and weeks analyzed by metabolic profiling multivariate statistical analysis. In analysis biomarker results metabolite profiles, formate, glutamine, histidine, isoleucine, leucine,...
In this study, UPLC-QqQ/MS-based lipidomics was applied to profile various lipids from RAW264.7 macrophages treated with different concentrations of lipopolysaccharide (LPS). The degree inflammation increased the LPS concentration. To elucidate altered lipid metabolism inflammatory macrophages, we targeted analyze 25 classes LPS-treated cells. As a result, 523 species were successfully profiled by using optimal UPLC and MRM. Statistical data analyses such as PCA, PLS-DA, HCA differentiated...
Ginseng root has been used in traditional oriental medicine for the enhancement of immune system function. The immunostimulatory effects ginseng berry polysaccharides, however, remain unclear. Effects polysaccharides from on activation natural killer (NK) cells and inhibition tumors are reported. A crude polysaccharide was isolated as a portion (GBPP) further fractionated using gel filtration chromatography to obtain three fractions GBPP-I, -II -III. GBPP-I consisted mainly galactose (46.9%)...
Metabolomics approaches are becoming popular for a rational and efficient approach to standardize research including optimal harvest time determination improve the values of plant raw materials. In this study, multivariate statistical analysis metabolites from Artemisia gmelinii Weber ex Stechm (AG) by growth stage according (from June October) was performed ultra-performance liquid chromatography (UPLC) coupled with quadrupole flight mass spectrometry (Q-TOF/MS). Secondary metabolite...
Although Astragalus membranaceus is known to have anti-inflammatory, anti-obesity, and anti-oxidant properties, the underlying apoptotic mechanism of extract has never been elucidated in prostate cancer. In this paper, a water from dried root (WAM) was investigated cancer cells association with heat shock protein 27 (HSP27)/androgen receptor (AR) signaling. WAM increased cytotoxicity sub-G1 population, cleaved poly (ADP-ribose) polymerase (PARP) cysteine aspartyl-specific protease 3 (caspase...