A5100329536- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Agriculture, Soil, Plant Science
- Seaweed-derived Bioactive Compounds
- RNA and protein synthesis mechanisms
- Pharmacological Effects of Natural Compounds
- Enzyme Catalysis and Immobilization
- Enzyme Production and Characterization
- Ginseng Biological Effects and Applications
- GABA and Rice Research
- Natural product bioactivities and synthesis
- Weed Control and Herbicide Applications
- Phytase and its Applications
- Phytochemistry and Biological Activities
- Viral Infectious Diseases and Gene Expression in Insects
- Essential Oils and Antimicrobial Activity
- Microbial Metabolic Engineering and Bioproduction
- Biochemical and Molecular Research
- Polyamine Metabolism and Applications
- Pesticide and Herbicide Environmental Studies
- Plant Stress Responses and Tolerance
- Bioactive natural compounds
- Glycosylation and Glycoproteins Research
- Fatty Acid Research and Health
- Nutrition, Health and Food Behavior
Korea Food Research Institute
2011-2023
Kyungpook National University
2009-2022
Soonchunhyang University
2022
Andong National University
2009-2020
Gyeongnam National University of Science and Technology
2018
Hankyong National University
2007-2017
National Academy of Agricultural Science
2014
Columbia University Irving Medical Center
2013
University of California, Berkeley
2011
Energy Biosciences Institute
2011
ABSTRACT Environmental pollution by phosphorus from animal waste is a major problem in agriculture because simple-stomached animals, such as swine, poultry, and fish, cannot digest (as phytate) present plant feeds. To alleviate this problem, phytase Aspergillus niger PhyA widely used feed additive to hydrolyze phytate-phosphorus. However, it has the lowest relative activity at pH of stomach (3.5), where hydrolysis occurs. Our objective was shift optima match condition substituting amino...
Brown algae have been used for their nutritional value as well a source of bioactive compounds with antioxidant, anti-inflammatory, antimicrobial and anti-obesity effects. Obesity is an important condition implicated in various diseases, including diabetes, hypertension, dyslipidemia coronary heart disease. However, effects Eisenia bicyclis remain unknown.
Abstract In this study, we aimed to elucidate the antioxidant capacity of Eisenia bicyclis and evaluated its activity using various assay systems such as 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging, 2,2‐azino‐bis (3‐ethylbenzthiazoline‐6‐sulfonic acid) (ABTS) reducing power ability, content total polyphenol. Among all performed experiments, ethyl acetate fraction E. exhibited higher activities. From finding, isolation purification were on identified dieckol phlorofucofureoeckol‐A...
Amyloid β-peptide (Aβ) pathology is an invariant feature of Alzheimer disease, preceding any detectable clinical symptoms by more than a decade. To this end, we seek to identify agents that can reduce Aβ levels in the brain via novel mechanisms. We found (20S)-Rg3, triterpene natural compound known as ginsenoside, reduced cultured primary neurons and brains mouse model disease. The (20S)-Rg3 treatment induced decrease association presenilin 1 (PS1) fragments with lipid rafts where catalytic...
Piperlongumine, a pyridone alkaloid isolated from Piper longum L., exhibited potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA) and activating factor (PAF), without any that thrombin. Piperlongumine was used as lead compound for the synthesis of new antiplatelet agents. Seven synthetic compounds were newly synthesized 3,4,5-trimethoxycinnamic (TMCA). They 1-piperidin-1-yl-3-(3,4,5-trimethoxy-phenyl)prop-2-en-1-one (1'),...
Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated best Purified compounds, sanggenon B, albanol B D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells Regarding underlying molecular mechanisms, further investigations that treatments with Albanol reduced pro-inflammatory cytokines decreased expression inducible nitric oxide synthase...
Abstract The present study investigated the chemical composition, antioxidant, antimicrobial, and anti‐inflammatory activities of essential oil (EO) derived from wild rhizomes Atractylodes macrocephala Koidz. (AMA) growing in Qimen County (eastern China). GC/MS analysis identified fifteen compounds, representing 92.55 % AMA EO. major compounds were atractylone (39.22 %), β ‐eudesmol (27.70 thymol (5.74 hinesol (5.50 11‐isopropylidenetricyclo[4.3.1.1(2,5)]undec‐3‐en‐10‐one (4.71 %)....
Repeated administration of opioid analgesics for pain treatment can produce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus, this study investigated whether spinally (centrally) administered orexin A attenuates opioid-induced (OIH).[D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), a selective μ-opioid receptor agonist, was used to induce mechanical hypersensitivity and intradermally (4 times, 1-hour intervals) on the rat hind paw dorsum. To determine post- or...
This study was performed to characterize the CLA production ability of a bacterial strain, Bifidobacterium breve LMC 520, which can actively convert linoleic acid (LA) cis-9,trans-11 conjugated (CLA), major isomer derived from microbial enzymatic conversion. The culture conditions were optimized improve under aerobic conditions. B. 520 tested with different amounts LA in varied conditions, such as air, additives, and pH. A maximal level (up 90% substrate) obtained after 24 h incubation...
Combined efforts: A high-throughput protein-expression and screening method (HIGH method, see picture) provides a rapid approach to the discovery of active glycoside hydrolases in environmental samples. HIGH combines cloning, protein expression, enzyme hydrolysis one pot; thus, entire process from gene expression activity detection requires only three hours. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
Phenalenyl (PLY)-based metal complexes are a new addition to the complex family. Various applications of metal-based phenalenyl (metal-PLY) have been reported, such as catalyst, quantum spin simulators, electronic devices, and molecular conductors, but biological significance metal-PLY (metal = Co(II), Mn(III), Ni(II), Fe(III), Al(III)) systems has yet be explored. In this study, anticancer properties were investigated in ovarian cancer cells (SKOV3 HEY A8), cytotoxicity was comparable that...
Abstract This article reports the cell‐free expression of functional Lipase B from Candida antarctica (CalB) in an Escherichia coli extract. Although most synthesized CalB was insoluble under conventional reaction conditions, combined use molecular chaperones led to soluble CalB. In addition, enzyme generated by applying optimal redox potential. When examined using p ‐nitrophenyl palmitate as a substrate, specific activity higher than that reference protein produced Pichia pastoris . These...
The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement an exploratory test programme. Monitoring testing programmes are routinely implemented by 17 Provincial Veterinary Services products regional offices the Animal Plant Quarantine Agency (QIA) products. project conducted at QIA headquarters is designed to substances that not included in monitoring enforcement programmes....
Pistacia chinensis has been used for various purposes in China including as an understock grafting vera. However, little attention was given to its health promoting effects. Therefore, this study, we investigated the effect of methanolic extract (PCME) containing resorcinol class phenolic lipids on pro-inflammatory mediators and heme oxygenase-1(HO-1) lipopolysaccharide stimulated RAW264.7 cells. While PCME (2.5–10 μg/ml) inhibited mRNA expressions inducible nitric oxide synthase (iNOS),...