A5006120097- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Heat shock proteins research
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Parkinson's Disease Mechanisms and Treatments
- Bacterial Genetics and Biotechnology
- Metalloenzymes and iron-sulfur proteins
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- Metal Extraction and Bioleaching
- Redox biology and oxidative stress
- Machine Learning in Bioinformatics
- Bioinformatics and Genomic Networks
- Enzyme Production and Characterization
- Bacteriophages and microbial interactions
- Signaling Pathways in Disease
- Muscle Physiology and Disorders
University of Kalyani
2016-2025
Université Paris-Saclay
2016
Hong Kong Baptist University
2014
University of Minnesota
2013
Buck Institute for Research on Aging
2010-2011
Indiana University School of Medicine
2008
Indiana University – Purdue University Indianapolis
2008
Indiana University
2008
University School
2008
Jadavpur University
2007
Colitis is an inflammatory disorder of the gastrointestinal tract. A widely consumed dietary nutrient, α-ketoglutarate (α-KG) known to play a crucial role in cellular metabolism and provide protection intestinal epithelium under various pathophysiological conditions. In this study, 2,4,6-trinitrobenzenesulfonic acid (TNBS) was used induce colitis Wistar rats. After 36 hours TNBS administration, rats were orally treated with solution α-KG at 1 g/kg body weight for 5 days. Development...
Background Resveratrol, a constituent of red wine, is important for cardioprotection. MicroRNAs are known regulators genes involved in resveratrol-mediated cardiac remodeling and the regulatory pathway involving microRNA has not been studied so far. Methods We explored cardioprotection by resveratrol ischemia/reperfusion model rat determined functions. miRNA profile was from isolated RNA using quantitative Real-time PCR based array. Systemic analyses array theirs targets were number...
The nuclear factor kappa B (NFkB) modulates a broad range of cellular processes. NFkB pathway is stimulated by various signaling cascades and involved in cross-talks the cell. controls pro-inflammatory response TNFα IL-1 pathway. Inflammation defense mechanism body but when prolonged chronic it results diseases, such as cancer, neurodegeneration, ageing, obesity, etc. could be regulated at levels to control inflammation. As within cell, better understanding inter-linked using computational...
An important challenge in translational bioinformatics is to understand how genetic variation gives rise molecular changes at the protein level that can precipitate both monogenic and complex disease. To this end, we compiled datasets of human disease-associated amino acid substitutions (AAS) contexts inherited disease, functional polymorphisms with no known disease association, somatic mutations cancer, compared them respect predicted sites proteins. Using sequence homology-based tool SIFT...
Twelve chemolithotrophic strains were isolated from temperate orchard soil on reduced sulfur compounds as energy and electron sources characterized the basis of their physiological properties ability to oxidize various compounds. The new isolates could tetrathionate well thiosulfate, oxidation latter involved conversion thiosulfate followed by its accumulation eventual sulfate, manifested in production acid. mesophilic, neutrophilic, Gram-negative coccoid bacteria had a respiratory...
Abstract Leishmaniasis, a major neglected tropical disease, affects millions of individuals worldwide. Among the various clinical forms, visceral leishmaniasis (VL) is deadliest. Current antileishmanial drugs exhibit toxicity- and resistance-related issues. Therefore, advanced chemotherapeutic alternatives are in demand, currently, plant sources considered preferable choices. Our previous report has shown that chloroform extract Corchorus capsularis L. leaves exhibits significant effect...
Phenalenyl (PLY)-based metal complexes are a new addition to the complex family. Various applications of metal-based phenalenyl (metal-PLY) have been reported, such as catalyst, quantum spin simulators, electronic devices, and molecular conductors, but biological significance metal-PLY (metal = Co(II), Mn(III), Ni(II), Fe(III), Al(III)) systems has yet be explored. In this study, anticancer properties were investigated in ovarian cancer cells (SKOV3 HEY A8), cytotoxicity was comparable that...
Cilostazol is a phosphodiesterase III inhibitor characterized by poor solubility. This limitation can be overcome using drug carrier capable of delivering the to target site. Cyclodextrins are essential as carriers because their outstanding complexation abilities and capacity improve bioavailability. study comprises two stages: The first involves verifying different cyclodextrins towards cilostazol. was accomplished molecular docking simulations (MDS) density functional theory (DFT). Both...
Candida albicans causes two types of major infections in humans: superficial infections, such as skin and mucosal infection, life-threatening systemic like airway catheter-related blood stream infections. It is a polymorphic fungus with distinct forms (yeast hyphal) the morphological plasticity strongly associated many disease causing proteins. In this study, 137 hyphae proteins from (C. albicans) were collected different sources to create Protein-Protein Interaction (PPI) network. Out...
The structure of the ribonucleoprotein complexes is crucial to viral transcription and replication influenza virus, but association nucleoprotein (NP) with polymerase remains be characterized at molecular level. Here, we identify a peptide acidic subunit PA(1-27) that associates NP. Docking dynamics simulations suggest similar NP binding site PA(1-186). PA(1-27)-NP complex by surface plasmon resonance fluorescence using recombinant proteins pull-down assays in infected cells. may have role...