A5046559322- Cardiac Ischemia and Reperfusion
- Sirtuins and Resveratrol in Medicine
- High-Temperature Coating Behaviors
- Intermetallics and Advanced Alloy Properties
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cardiac Arrest and Resuscitation
- Electron Spin Resonance Studies
- Cardiac electrophysiology and arrhythmias
- Redox biology and oxidative stress
- High Temperature Alloys and Creep
- Fuel Cells and Related Materials
- Electrochemical Analysis and Applications
- Antioxidant Activity and Oxidative Stress
- Nitric Oxide and Endothelin Effects
- Advanced ceramic materials synthesis
- Anesthesia and Neurotoxicity Research
- Nuclear Materials and Properties
- Heat shock proteins research
- Biochemical effects in animals
- Autophagy in Disease and Therapy
- Catalytic Processes in Materials Science
- Phytochemicals and Antioxidant Activities
- Electrocatalysts for Energy Conversion
- Cardiovascular Function and Risk Factors
Defence Metallurgical Research Laboratory
2014-2025
GLA University
2016-2025
International Institute for Population Sciences
2024
University of Rajshahi
2023-2024
Khulna University
2024
National Institute of Technology Jamshedpur
2024
Tata Steel (India)
2024
Jadavpur University
1996-2023
Indian Institute of Technology Kanpur
2002-2022
S.N. Bose National Centre for Basic Sciences
2016-2022
AimsOn the basis of our previous reports that cardioprotection induced by ischaemic preconditioning induces autophagy and resveratrol, a polyphenolic antioxidant present in grapes red wine preconditioning-like effects, we sought to determine if resveratrol could induce autophagy.
While much is known about the beneficial effects of myocardial stress adaptation, relatively less information available adaptive mechanisms. To explore signaling pathways isolated working rat hearts were divided into three groups. Group I was adapted to by conventional technique repeated ischemia and reperfusion consisting 5 min followed 10 reperfusion, four times. II treated with 100 μM genistein, a tyrosine kinase inhibitor, preconditioning as described for group I. The third group,...
This review describes the dose-dependent health benefits of resveratrol, a polyphenolic antioxidant that is found in variety foods, especially grape skin and red wine. Resveratrol provides diverse including cardioprotection, inhibition low-density lipoprotein, activation nitric oxide (NO) production, hindering platelet aggregation [32] A.A.E. Bertelli, D.E. Giovannini, R.L. Caterina, W. Bernini, M. Migliori Fregoni et al., Antiplatelet activity cis-resveratrol, Drugs Exp Clin Res 22 (1996),...
We have recently demonstrated that myocardial adaptation to ischemia triggers a tyrosine kinase regulated signaling pathway leading the translocation and activation of p38 MAP MAPKAP 2. Since oxidative stress is developed during ischemic since free radicals been shown function as an intracellular agent nuclear transcription factor, NFκB, we examined whether NFκB was involved in process. Isolated perfused rat hearts were adapted by repeated reperfusion. Hearts pretreated with genistein block...
Reperfusion of ischemic myocardium causes cardiomyocyte apoptosis in concert with downregulation Bcl-2 gene. Ischemic preconditioning (PC) mediated by cyclic episodes short-term ischemia and reperfusion reduces apoptotic cell death. PC also triggers a signaling pathway potentiating tyrosine kinase phosphorylation leading to the activation p38 MAP MAPKAP 2. The nuclear transcription factor, NFkappaB, plays crucial role this process. Because NFkappaB is target oxygen free radicals an...
We investigated whether enhanced expression of alphaB crystallin, a stress-inducible molecular chaperone the small heat shock family, can protect myocardial contractile apparatus against ischemia reperfusion (I/R) injury. Transgenic mice overexpressing crystallin were generated using 0.76 kb rat cDNA cloned into pCAGGS plasmid driven by human cytomegalovirus system. Southern analysis confirmed transgene integration and Northern Western blotting characterized (3.1-fold 6.9-fold elevations in...
Resveratrol (trans-3,4',5-trihydroxystilbene), a recently described grape-derived polyphenolic antioxidant, has been found to protect the heart from ischemic-reperfusion injury. The present study sought determine mechanism of cardioprotection by investigating ability resveratrol precondition heart. Isolated perfused rat hearts were randomly divided into six groups: group I was for 15 min with Kreb-Henseleit buffer (KHB) only; II 10 microM resveratrol; III plus 100 N(G)-nitro-L-arginine...