A5052858225- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Biochemical Analysis and Sensing Techniques
- Macrophage Migration Inhibitory Factor
- Helicobacter pylori-related gastroenterology studies
- Probiotics and Fermented Foods
- Protease and Inhibitor Mechanisms
- Microbial Metabolites in Food Biotechnology
- Peptidase Inhibition and Analysis
- Inflammatory mediators and NSAID effects
- Endometriosis Research and Treatment
- Connective tissue disorders research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Indian Institute of Chemical Biology
2012-2023
Jadavpur University
2014
The zinc-dependent matrix metalloproteinases (MMPs) are key enzymes associated with extracellular (ECM) remodeling; they play critical roles under both physiological and pathological conditions. MMP-9 activity is linked to many processes, including rheumatoid arthritis, atherosclerosis, gastric ulcer, tumor growth, cancer metastasis. Specific inhibition of may be a promising target for therapy diseases characterized by dysregulated ECM turnover. Potent inhibitors an indole scaffold were...
Indomethacin, a known nonsteroidal anti-inflammatory drug (NSAID) induces gastric inflammation, causing degradation of the extracellular matrix by specific metalloproteinases (MMPs). We investigated antiulcer efficacy 3-indolyl furanoids (3g and 3c, i.e., methoxy substitution at 4- 5-positions indole ring, respectively), derived from indomethacin. Interestingly, 3g protected against indomethacin-induced gastropathy in vivo inhibiting MMP-9. Our work established chemical modification strategy...
Aims: Enterococci may be beneficial to health and can used as starter cultures for fermented foods.Therefore, in this study were identified from some Nigerian foods, their technological properties evaluated order gain a better understanding of usefulness or probiotics.Methodology results: Five isolates various traditional foods Enterococcus gallinarum based on phenotypic genotypic tests.Technological examined antimicrobial investigations carried out.Out the five strains only E. W211 T71...
Enterococcus gallinarum strains isolated from some Nigerian fermented foods were found to produce bacteriocins. The bacteriocins had a broad spectrum of activity against both Gram-positive and negative bacteria. effects the bacteriocinogenic organ- isms on Staphylococcus aureus infections in rats evaluated. Sprague-Dawley infected with S. MTCC 737 treated E. T71 different concentrations W211 T71. infection caused significant upregulation aspartate aminotransferase alanine levels sera rats....