A5101690906- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Acute Kidney Injury Research
- Kidney Stones and Urolithiasis Treatments
- Parathyroid Disorders and Treatments
- Complement system in diseases
- Renal and Vascular Pathologies
- Potassium and Related Disorders
- Atherosclerosis and Cardiovascular Diseases
- Rheumatoid Arthritis Research and Therapies
- Renal Transplantation Outcomes and Treatments
- Vestibular and auditory disorders
- Organ Donation and Transplantation
- Hemodynamic Monitoring and Therapy
- Bipolar Disorder and Treatment
- Autoimmune Bullous Skin Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Disease and Adiposity
- SARS-CoV-2 and COVID-19 Research
- Heart Failure Treatment and Management
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Organ Transplantation Techniques and Outcomes
Ajou University
2014-2024
Weatherford College
2023
Ajou University Hospital
2022
Pediatric Nephrology of Alabama
2017
Hanyang University
2016
Keimyung University
2006-2012
Sungkyunkwan University
2011
Pusan National University
2011
University of Washington
2000-2004
Seattle Children's Hospital
2004
Abstract. Progressive renal disease as a result of fibrosis is caused in part by an impairment the proteolytic machinery that normally regulates matrix turnover. The goal present study was to determine whether genetic deficiency tissue inhibitor metalloproteinases-1 (TIMP-1) could attenuate interstitial unilateral ureteral obstruction (UUO). Groups wild-type ( Timp-1 ) mice and TIMP-1—deficient timp-1 were killed after 3 14 d UUO or sham operation. mRNA levels significantly increased 37-...
ABSTRACT. The urokinase cellular receptor (uPAR) recognizes the N-terminal growth factor domain of urokinase-type plasminogen activator (uPA) and is expressed by several cell types. present study was designed to test hypothesis that uPAR regulates renal fibrogenic response chronic injury. Groups wild-type (+/+) deficient (−/−) mice were investigated between 3 14 d after unilateral ureteral obstruction (UUO) or sham surgery. Not detected in normal kidneys, mRNA UUO +/+ mice. By <i>in situ</i>...
ABSTRACT. Interstitial cells have been implicated in the pathogenesis of renal fibrosis. Given that urokinase receptor (uPAR) is known to play a role cell adhesion, migration, and angiogenesis, present study was designed evaluate uPAR regulation phenotypic composition interstitial (macrophages, myofibroblasts, capillaries) response chronic injury. Groups wild-type (+/+) knockout (−/−) mice were investigated between 3 14 d after unilateral ureteral obstruction (UUO) or sham surgery (n = 8 per...
<h3>Objectives</h3> To investigate the frequency and pattern of nystagmus associated with isolated cerebellar infarction in territory superior artery (SCA) to discuss its possible mechanism. <h3>Methods</h3> We identified 41 consecutive patients SCA diagnosed by MRI. Each patient completed a standardised dizziness questionnaire underwent neurotological evaluations. Eye movements were recorded using 3-dimensional video-oculography during acute period. <h3>Results</h3> Approximately half...
For phosphate control, patient education is essential due to the limited clearance of by dialysis. However, well-designed randomized controlled trials about dietary and binder have been scarce.We enrolled maintenance hemodialysis patients them into an group (n = 48) or a control 22). We assessed patients' drug compliance their knowledge using questionnaire.The primary goal was increase number who reached calcium-phosphorus product lower than 55. In group, 36 (75.0%) achieved goal, as...
Background: Lateropulsion of the body—that is, falling to one side—is a well-known clinical feature stroke in posterior circulation. Body lateropulsion as an isolated or predominant manifestation pontine has not been reported previously. Objective: To elucidate possible mechanisms patients presenting with body symptom infarction. Methods: Between May 2004 and February 2006, out 134 admitted stroke, we identified 8 (6%) consecutive Keimyung University Stroke Registry who had main symptom....
Abstract Background In the general population, trabecular bone score (TBS) represents microarchitecture and predicts fracture risk independent of mineral density (BMD). A few studies reported that TBS is significantly reduced in dialysis patients. Chronic kidney disease-mineral disorder (CKD-MBD) are accompanied by increased risk, cardiovascular morbidity, mortality. We investigated whether associated with comorbidity related to CKD-MBD or frailty hemodialysis Methods this prospective...
Patients undergoing hemodialysis are susceptible to sarcopenia. As intracellular reservoirs of water, skeletal muscles important contributors intradialytic hypotension. This study was designed determine the role muscle mass in hypotension.In a cross-sectional study, body composition 177 patients measured immediately after using bioelectrical impedance analysis. The parameters were mass, and extracellular water contents, total cell-membrane functionality (in phase angle at 50 kHz). Data from...
Objective Contrast agents used for radiological examinations are an important cause of acute kidney injury (AKI). We developed and validated a machine learning clinical scoring prediction model to stratify the risk contrast-induced nephropathy, considering limitations current classical models.
<i>Background:</i> Previous findings have demonstrated that the expression of cytotoxic effector molecules is increased in acute rejection renal allografts. In present study, we serially examined gene perforin, granzyme B and Fas ligand (FasL) peripheral blood lymphocytes (PBLs) allograft recipients to assess potential their as a marker rejection. <i>Methods:</i> PBLs were isolated from samples taken on days 2, 4, 6, 8, 10 12 after transplantation. Competitive PCR was...
Abstract Introduction: Malnutrition is prevalent in hemodialysis (HD) patients, and the risk of mortality strongly correlated with malnutrition. Current methods nutritional evaluation are mostly subjective, time‐consuming, cumbersome. Creatinine index (CI) geriatric (GNRI) very simple objective to assess status HD patients. The present study compares performance CI GNRI as assessment tools. Methods: Eighty‐eight patients end‐stage renal disease on were recruited from a single tertiary...
Bone morphogenetic protein-7 (BMP-7) plays a critical role in renal development, accelerates recovery from acute injury, and more recently it has been shown to delay progressive disease. The present study was designed investigate the effect of BMP-7 on interstitial fibrosis rat protein-overloaded model.Renal disease induced 26 rats by daily intraperitoneal injections bovine serum albumin (BSA); controls (n = 28) were injected with saline. Half each group treated human recombinant (300...
Mushroom-related poisoning can cause acute kidney injury. Here we report a case of injury after ingestion Amanita punctata, which is considered an edible mushroom. Gastrointestinal symptoms occurred within 24 hours from the mushroom intake and were followed by asymptomatic period, injury, elevation liver pancreatic enzymes. Kidney function recovered with supportive care. Nephrotoxic should be as
<i>Background:</i> Growth arrest and DNA damage-45γ (GADD-45γ) is induced in response to environmental stresses functions the regulation of cell cycles. Previous findings by our group suggested that GADD45γ contributed renal tubular damage through induction inflammatory fibrogenic molecules. We examined effects urinary expression on decline function with IgA nephropathy present study. <i>Methods:</i> Patients (n = 62) were followed for a total 710.3 ± 287.5 days. The...
This study was to investigate clinical characteristics and any differential trends in survival among renal replacement therapy (hemodialysis [HD], peritoneal dialysis [PD], kidney transplantation [KT]) Korean end-stage disease (ESRD) population.We tried analyze retrospectively the rate adjusted by risk factors relative stratified key 447 ESRD patients who began or had a transplant at Ajou University Hospital from 1994 2004.In Cox curves, KT best rate, HD better than PD patients.The...
Angelicae Gigantis Radix (AGR) is the most frequently used medicinal plats for patients with gynecological problems, especially pregnancy (1,2). This study was designed to investigate effects of on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats. We investigated AGR Changes body weights and food water uptake 5 weeks. In addition, we examined ovary weights. Finally, also observed histopathological changes PCO our results, administration group restored ovary/body...
Purpose We aimed to develop a model of chronic kidney disease (CKD) progression for predicting the probability and time from various CKD stages renal replacement therapy (RRT), using 6 months clinical data variables routinely measured at healthcare centers. Methods Data were derived electronic medical records Ajou University Hospital, Suwon, South Korea October 1997 September 2012. included patients who diagnosed with (estimated glomerular filtration rate [eGFR] < 60 mL·min–1·1.73 m–2 ≥ 3...
Estimated glomerular filtration rate (eGFR) is one of the most important guidelines in deciding optimal timing dialysis initiation. In present study, we calculated eGFR at time hemodialysis (HD) initiation using 5 commonly used equations to relate them with clinical and laboratory characteristics patients evaluate which these best define HD initiation.We retrospectively analyzed 409 end-stage renal disease who were newly started on treatment our institution. The was Cockcroft-Gault equation,...