A5026178717- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Complement system in diseases
- Potassium and Related Disorders
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Sepsis Diagnosis and Treatment
- Machine Learning in Healthcare
- Renal Transplantation Outcomes and Treatments
- Alcohol Consumption and Health Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metabolism and Genetic Disorders
- Pregnancy and Medication Impact
- Organ Transplantation Techniques and Outcomes
- Stroke Rehabilitation and Recovery
- Neuroendocrine Tumor Research Advances
- Cardiac Ischemia and Reperfusion
- Renal cell carcinoma treatment
Chung-Ang University
2023-2024
Seoyeong University
2024
Seoul National University Bundang Hospital
2019-2023
Seoul National University
2015-2021
Seoul National University Children's Hospital
2016
Background. The efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been investigated in kidney transplant recipients (KTRs) with diabetes. We evaluated the impact SGLT2i a multicenter cohort diabetic KTRs. Methods. A total 2083 KTRs diabetes were enrolled from 6 centers Korea. Among them, 226 (10.8%) patients prescribed for >90 d. primary outcome was composite all-cause mortality, death-censored graft failure (DCGF), serum creatinine doubling. An acute dip...
Acute kidney injury (AKI) is commonly encountered in clinical practice and associated with poor patient outcomes increased health care costs. Despite it posing significant challenges for clinicians, effective measures AKI prediction prevention are lacking. Previously published models mostly have a simple design without external validation. Furthermore, little known about the process of linking model output decisions due to black-box nature neural network models.We aimed present an externally...
Patients undergoing hemodialysis are susceptible to sarcopenia. As intracellular reservoirs of water, skeletal muscles important contributors intradialytic hypotension. This study was designed determine the role muscle mass in hypotension.In a cross-sectional study, body composition 177 patients measured immediately after using bioelectrical impedance analysis. The parameters were mass, and extracellular water contents, total cell-membrane functionality (in phase angle at 50 kHz). Data from...
Background: Serum uric acid (SUA) is recognized as a risk factor for chronic kidney disease (CKD) and mortality.However, there controversy to whether high or low level of SUA related the CKD progression death, it differs between males females.Methods: We included 143,762 adults who underwent voluntary health screening 1995 2009 in Korea.For each sex, we divided participants into sex-specific quintiles according levels compared end-stage renal (ESRD) incidence mortality groups with those...
The significance of ambulatory blood pressure (ABP) in Korean patients with chronic kidney disease (CKD) relation to renal outcome or death remains unclear. We investigated the role ABP predicting end-stage CKD.We enrolled 387 hypertension and CKD who underwent monitoring were followed for 1 year. Data on clinical parameters outcomes from August 2014 May 2018 retrospectively collected. composite endpoint was death. Patients grouped according mean ABP.There 66 events, 52 cases, 15...
See commentary "A novel role of copeptin as a biomarker for the prediction treatment response in hyponatremia" Volume 40 on page 329.
Renal fibrosis is a progressive chronic kidney disease that ultimately leads to end-stage renal failure. Despite several approaches combat fibrosis, an experimental model evaluate currently available drugs not ideal. We developed fibrosis-mimicking models using three-dimensional (3D) co-culture devices designed with three separate layers of tubule interstitium, namely, epithelial, fibroblastic, and endothelial layers. introduced human proximal tubular epithelial cells (HK-2), umbilical-vein...
Although C1q nephropathy (C1qN) was introduced three decades ago, the clinical significance and renal outcomes of C1qN remain unclear. This study aimed to evaluate characteristics C1qN, including outcomes, by performing a matched comparison within multicenter cohort. We enrolled 6,413 adult patients who underwent kidney biopsy between January 2000 2018 at tertiary hospitals in Korea. compared 23 with those focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD) were age,...
The clinical significance and renal outcomes of C1q nephropathy (C1qN) are unclear; therefore, the implications C1qN as a new pathological entity uncertain. We compared characteristics glomerulonephritis reclassified into cases that meet definition not included in C1qN.
Background A laparoscopic approach is widely used in abdominal surgery. Although several studies have compared surgical and oncological outcomes between surgery (LS) open (OS) rectal cancer patients, there been few on postoperative renal outcomes. Methods We conducted a retrospective cohort study involving 1,633 patients who underwent 2003 2017. Postoperative acute kidney injury (AKI) was diagnosed according to the serum creatinine criteria of Kidney Disease: Improving Global Outcomes...
Organ crosstalk between the kidney and heart has been suggested. Acute injury (AKI) acute failure (AHF) are well-known independent risk factors for mortality in hospitalized patients. This study aimed to investigate if these conditions have an additive effect on patients, as this not explored previous studies.We retrospectively reviewed records of 101,804 patients who visited two tertiary hospitals Republic Korea over a period 5 years. AKI was diagnosed using serum creatinine-based criteria,...
Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological clinical differences between cases of primary GN C3-dominant (C3D-GN) nondominant (C3ND-GN) deposition.We extracted data from the Korean GlomeruloNEphritis sTudy (KoGNET). C3D-GN was defined as staining two grades greater than C1q, C4, immunoglobulin via immunofluorescence analysis. To overcome large difference number patients C3ND-GN...
Minimal change disease (MCD) is characterized by edema and nephrotic range proteinuria (NS). However, the fate of MCD without requires elucidation. We retrospectively reviewed 79 adults diagnosed with primary at their initial renal biopsy a tertiary hospital between May 2003 June 2017. Clinicopathologic features were compared patients NS. The frequency flaring to outcomes assessed during follow-up. There 20 59 in Non-NS NS groups, respectively. group had lower acute kidney injury (AKI)...
We aimed to investigate the differences in health screening, including medical checkups and cancer between HBV carriers non-carriers Republic of Korea. In fifth Korean National Health Nutrition Examination Survey (KNHANES V), conducted 2010 2012, 17,865 persons who answered regarding their HBV-infection status, checkup history, liver screening general within past years were included final analysis. total, 295 carriers. Logistic regression models used compare check-up rate non-HBV The more...
Backgrounds Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on accuracy and effectiveness markers is unknown. Methods We retrospectively enrolled participants health screening programs at three hospitals from 1995 2009. defined two different participant groups YR1 YR3, which had available 1-year...
overload(AFO equivalent to over hydration [OH]) value from BCM showed 1.53 L of waterwas over-hydrated.Although there was no correlation between OH BCMand water deficit classic equation, total body (TBW) estimated withconventional formula and BIA significant (r=0.861,p<0.001).While the Bland -Altman plot indicated that proportional bias present(r=0.617,p<0.001).Intracellular (ICW) measured by significantcorrelation with TBW calculated conventional (r= 0.679, p <0.001).ICW underestimated...
Background: Assessment of eplet mismatches in transplantation requires high-resolution (HR) molecular human leukocyte antigen (HLA) typing.However, HR typing is rarely applied to solid organ transplantation.We developed an algorithm derive genotype from a low-resolution (LR) one and evaluated its performance Korean population.Methods: Our multistep imputation process based on HLA haplotype allelic frequency dataset for the population.To evaluate algorithm, results 127 patients who underwent...
<sec> <title>BACKGROUND</title> Acute kidney injury (AKI) is commonly encountered in clinical practice and associated with poor patient outcomes increased health care costs. Despite it posing significant challenges for clinicians, effective measures AKI prediction prevention are lacking. Previously published models mostly have a simple design without external validation. Furthermore, little known about the process of linking model output decisions due to black-box nature neural network...
Abstract BACKGROUND AND AIMS Minimal change lesion (MCD) accounts for 10–15% of adult patients with nephrotic syndrome and is characterized by edema, nephrotic-ranged proteinuria (NP) pathologic findings nearly normal appearance glomeruli on light microscopy, minimal staining immunoglobins extensive effacement foot process the podocyte. However, fate MCD typical without (Non-NP) needs to be defined in more details. METHOD We enrolled 79 first renal biopsy a tertiary teaching hospital from...
Abstract Background and Aims Patients undergoing hemodialysis showed higher prevalence of sarcopenia than that the healthy. As an intracellular water reservoir, skeletal muscle mass would be important to predict intradialytic hypotension. This study was designed reveal effect hypotension, which is also indicator volume status in patients under hemodialysis. Method 150 from three centers 2016 38 one center maintenance 2020 were enrolled this study, total 177 finally analyzed. We measured...