A5045330214- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Chemotherapy-induced organ toxicity mitigation
- Angiogenesis and VEGF in Cancer
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Lipid metabolism and disorders
- Systemic Sclerosis and Related Diseases
- Sirtuins and Resveratrol in Medicine
- Abdominal vascular conditions and treatments
- Renal and related cancers
- Renal cell carcinoma treatment
- Pediatric Urology and Nephrology Studies
- Renin-Angiotensin System Studies
- Mast cells and histamine
- Kruppel-like factors research
- Genomics, phytochemicals, and oxidative stress
- Potassium and Related Disorders
- Systemic Lupus Erythematosus Research
- Lymphatic System and Diseases
- Parathyroid Disorders and Treatments
- Vasculitis and related conditions
- Muscle and Compartmental Disorders
Chonbuk National University Hospital
2015-2025
Jeonbuk National University
2016-2025
Government of the Republic of Korea
2024
Committee on Publication Ethics
2024
Institute for Basic Science
2023
Korea Advanced Institute of Science and Technology
2005-2023
Biomedical Research Institute
2021
Korea Institute of Oriental Medicine
2012-2013
Renal Research Institute
2012
Korea Research Institute of Bioscience and Biotechnology
2011
Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There a growing body evidence that activation p53 has critical role in cisplatin-induced renal apoptotic injury. The nicotinamide adenine dinucleotide-dependent protein deacetylase SIRT1 decreases apoptosis through deacetylating p53, and resveratrol known as an activator SIRT1. To study injury interaction with mouse proximal tubular cells (MPT) were treated examined expression level SIRT1, acetylation...
Background. Cisplatin is a chemotherapeutic agent used in treatment of malignant tumours. However, cisplatin produces various side effects, such as nephrotoxicity, neurotoxicity, emetogenesis and ototoxicity. Inflammation an important mechanism nephrotoxicity. Alpha-lipoic acid (α-LA) has anti-inflammatory effects that inhibit both adhesion molecule expression human endothelial cells monocyte by suppressing the nuclear factor-κB (NF-κB) signalling pathway. The goals this study were to...
Inflammation is a key mediator of renal ischemia-reperfusion (IR) injury. Gender disparities have been reported in acute and chronic kidney disease. In particular, males are considered to be more susceptible ischemic injury compared with females according animal studies. The purpose the present study was investigate effect gender on inflammatory response following IR mice. Experiments were performed male female C57BL/6 Two weeks prior study, castration or ovariectomy testosterone propionate...
Abstract Background The aim of this study was to evaluate the efficacy and safety acupuncture in treatment for allergic rhinitis. Methods This a multicenter, randomized, parallel‐controlled study. Participants were randomized either active acupuncture, sham or waitlist groups. groups received three times per week 4 weeks. In group, minimal at nonacupuncture points used. group did not receive any treatment. Results Of 238 participants, 97, 94, 47 individuals assigned respectively. After...
Sirtuin 2 (SIRT2), a NAD+-dependent histone deacetylase, is involved in carcinogenesis and genomic instability modulates proinflammatory immune responses. However, its role renal inflammatory injury has not been demonstrated. In this study, we explored the expression patterns of CXCL2 CCL2 kidney tissue from Sirt2−/− Sirt2+/+ mice mouse proximal tubular epithelial (MPT) cells. were significantly downregulated at both mRNA protein levels kidneys LPS-treated compared with those mice....
After insult to the kidney, a renal fibrotic process is initiated with sustained inflammation, fibroblast activation and accumulation of extracellular matrix (ECM). Tamoxifen has been used as an anti-estrogen for prevention treatment breast cancer. In this study, we investigated protective effects tamoxifen on unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis its molecular mechanism. Renal was induced by UUO in 7-week-old C57BL/6 mice. (50 mg/kg) given oral gavage 5...
Renal fibrosis is a common feature of all progressive chronic kidney diseases. Sirtuin 3(SIRT3) one the mitochondrial sirtuins, and plays role in regulation mitochondrialbiogenesis, oxidative stress, fatty acid metabolism, aging. Recently, honokiol (HKL), as apharmaceutical SIRT3 activator, has been observed to have protective effect against pressureoverload-induced cardiac hypertrophy by increasing activity. In this study, we investigatedwhether HKL, also effects unilateral ureteral...
Significance Statement Mesangial cells (MCs) in the kidney are essential to maintaining glomerular integrity, and their impairment leads major diseases including diabetic nephropathy (DN). Although high blood glucose elicits abnormal alterations MCs, underlying mechanism is poorly understood. We show that YAP/TAZ increased MCs of patients with DN two animal models DN. High directly induces activation through canonical Hippo pathway cultured MCs. Hyperactivation mouse recapitulates hallmarks...
Inflammatory mechanisms may play an important role in the pathogenesis of cisplatin nephrotoxicity. Agonists peroxisome proliferator-activated receptor-gamma (PPARgamma), such as rosiglitazone, have been recently demonstrated to regulate inflammation by modulating production inflammatory mediators and adhesion molecules. The purpose this study was examine protective effects rosiglitazone on nephrotoxicity explore mechanism its renoprotection.Mice were treated with or without pre-treatment...
Injury to the renal microvasculature may be a major factor in progression of disease; therefore, protection endothelial cells (EC) vasculature have therapeutic role fibrosis. Recently, soluble, stable, and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, was developed. The contribution COMP-Ang1 interstitial fibrosis, however, remains clarified. This study investigated effects on peritubular capillary EC cortex fibrogenic process that is triggered by...
Background. Cisplatin chemotherapy often causes acute kidney injury in cancer patients. The causative mechanisms of cisplatin-induced include renal inflammation, activation p53 tumour suppressor protein and tubular apoptosis. Luteolin, a flavone found medicinal herbs plants, has been reported to exhibit anti-inflammatory, antioxidant anticarcinogenic activities. purpose this study was investigate the anti-apoptotic effect luteolin on molecular mechanism. Methods. C57BL/6 mice were treated...
Cancer therapy often produces anemia, which is treated with erthropoietin (EPO) to stimulate erythrocyte production. However, concerns have recently arisen that EPO treatment may promote later tumor metastasis and mortality. The mechanisms underlying such effects are unknown, but it clear has pleiotropic in cell types other than hematopoietic cells. In this study, we investigated how affects lymphangiogenesis lymph node mouse models of breast cancer melanoma. these models, increased a manner...
Activation of mitogen-activated protein kinase phosphatase-1 (MKP-1), a dual-specificity phosphatase, regulates signaling. C-Jun N-terminal (JNK) and p38 are activated in cisplatin-induced renal injury. However, the change MKP-1 expression injury regulatory effect sirtuin 2 (SIRT2), nicotinamide adenine dinucleotide-dependent deacetylase, on remains unknown.To address these issues, we used constitutional Sirt2 knockout (KO) mice, transgenic (TG) mice with increased SIRT2 specifically...
It is often challenging to differentiate between IgG4-related disease (IgG4-RD) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) due their similar clinical presentations. Recently, growing evidence has suggested a strong connection AAV IgG4-RD. A 60-year-old woman was transferred our hospital with fever kidney dysfunction. Abdominal computed tomography revealed widespread infiltrative lesions in both kidneys. Laboratory tests subsequent renal biopsy confirmed disease. We...
Background Acute kidney injury following ischemia−reperfusion remains a substantial perioperative challenge lacking effective treatment. p21-activated kinase 4 (PAK4), downstream effector of Rho GTPase, has been explored in hepatic injury, but its role renal is unknown. Methods Wild-type and proximal tubule-specific Pak4 knockout mice underwent 25 min ischemia followed by 24 h reperfusion injury. Primary tubular cells HK-2 were exposed to hypoxia−reoxygenation investigate the vitro impact...
Background. Inflammatory processes have been recently seen as underlying the pathogenesis of diabetic nephropathy. Angiopoietin-1 (Ang1) plays essential roles in regulating vascular growth, development, maturation, permeability and inflammation. We developed a soluble, stable potent Ang1 variant, cartilage oligomeric matrix protein (COMP)-Ang1. Methods. In this study, db/db mice were treated with recombinant adenovirus expressing either COMP-Ang1 or LacZ. Histology, inflammatory, metabolic,...
Ischemia followed by reperfusion induces microvascular endothelial cell injury, leading to the loss of functions such as regulation vascular tone, tissue perfusion, permeability, and inflammation in kidney. Improvement this dysfunction could be a good approach treating ischemia-reperfusion-induced renal injury. Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) is variant native angiogenic factor angiopoietin-1 engineered have higher activity. We evaluated protective effect...
Metabolic syndrome is characterized by insulin resistance, dyslipidemia and hypertension. These metabolic changes contribute to the development of obesity-induced kidney injury. AMP-activated protein kinase (AMPK) a ubiquitous enzyme that involved in cellular response stress. Metformin, an AMPK activator, has been reported exert protective effect against non-alcoholic steatohepatitis. However, little known about its role pathogenesis renal The aim this study was investigate effects metformin...
Oxidative stress and inflammation are implicated in the pathogenesis of cisplatin-induced nephrotoxicity. l-2-oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug, increases cellular glutathione (GSH). OTC converted to by intracellular enzyme, oxoprolinase. To date, protective role on renal injury has not been investigated. The purpose present study was examine effect mechanism its protection.Mice were treated with cisplatin or without administration OTC. generation reactive oxygen...
Fractalkine is a unique chemokine that functions as chemoattractant well an adhesion molecule on endothelial cells activated by proinflammatory cytokines. Alpha-lipoic acid (LA), naturally occurring dithiol compound, essential cofactor for mitochondrial bioenergetic enzymes. LA improves glycemic control, reduces diabetic polyneuropathies, and mitigates toxicity associated with heavy metal poisoning. The effects of processes sepsis, however, are unknown. We evaluated the antiinflammatory...