A5050272646- Genomics, phytochemicals, and oxidative stress
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- MicroRNA in disease regulation
- Natural Antidiabetic Agents Studies
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Drug-Induced Hepatotoxicity and Protection
- Adipose Tissue and Metabolism
- Glutathione Transferases and Polymorphisms
- Free Radicals and Antioxidants
- Pregnancy and preeclampsia studies
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Gestational Diabetes Research and Management
- Molecular Biology Techniques and Applications
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
SRM Institute of Science and Technology
2016-2025
Stanford University
2013-2023
Annamalai University
2003-2021
SRM University
2013-2020
Tamil Nadu Government Dental College and Hospital
2013
Ragas Dental College & Hospital
2013
GITAM University
2013
National Institute of Mental Health and Neurosciences
2007-2011
Jeonbuk National University
2010
Anna University, Chennai
2009
Abstract Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web Science) on “polyphenols diabetes” significantly increased since 2010. This review highlights the advances opportunities dietary agents. prevent manage Type 2 diabetes mellitus via insulin‐dependent approaches, for instance, protection pancreatic islet β‐cell, reduction β‐cell apoptosis, promotion proliferation,...
Abstract We investigated the association of redox regulator Nuclear factor erythroid 2-related 2 (Nrf2) and inflammatory cytokines as well clinical remission in patients with recent onset type diabetes (DM). Blood was collected from 180 DM (105 males/75 females) 150 control subjects (86 males/64 females). glucose, HbA1c, lipid profile Nrf2 levels were determined along circulatory study subjects. The data adjusted confounding factors such age sex using multiple logistic regression analysis....
Nuclear factor erythroid 2-related 2 (Nrf2) is considered to be a 'master regulator' of the antioxidant response as it regulates expression several genes including phase II metabolic and enzymes thus plays an important role in preventing oxidative stress-mediated disorders, diabetes. In this study, for first time, we investigated protective properties naturally available antioxidant, pterostilbene (PTS), against pancreatic beta-cell apoptosis involvement Nrf2 its mechanism...
Abstract Objective Endothelial dysfunction highlights that it is a potential contributor in the pathogenesis of vascular complications arising from endoplasmic reticulum stress ( ER stress) and has been emerging as main causative factor failure. Here, we hypothesize natural flavonoid, quercetin plays an effective role reducing human umbilical vein endothelial cells. Materials methods Human cells were pre‐treated with different concentrations (0–100 μ m ) before inducing using tunicamycin TUN...
Nuclear factor erythroid 2-related 2 (Nrf2) remains a master regulator of cytoprotective and antioxidant genes. In this study, we investigated the antidiabetic role pterostilbene (PTS) in streptozotocin (STZ)-induced diabetic model through Nrf2-mediated mechanisms. The ability PTS to activate Nrf2 MIN6 cells was assessed by dissociation Nrf2-Keap1 complex at different time points expression ARE-driven downstream target genes Nrf2. Immunoblot experiments examining activation phosphorylation...
Chronic hyperglycemia and unusually high oxidative stress are the key contributors for diabetes in humans. Since nuclear factor E2-related 2 (Nrf2) controls expression of antioxidant- detoxification genes, it is hypothesized that targeted activation Nrf2 using phytochemicals likely to protect pancreatic β-cells, from damage, thereby mitigates complications diabetes. Naringenin one such activator Nrf2. However, currently not known whether protective effect naringenin against streptozotocin...
This study employed green chemistry to synthesize copper nanoparticles (CuNPs) using fresh root extract of Withania somnifera . The size, shape, morphology, and stability resultant CuNPs were investigated by UV‐Vis spectroscopy, FTIR, transmission electron microscopy (TEM), energy‐dispersive spectrophotometer. Crude extracts assessed phytochemically determine the presence alkaloids, flavonoids, phenols, saponins, steroids, tannins. absorption spectra show maximum at 330 nm, FTIR showed...