A5055077070- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Advanced Glycation End Products research
- Microbial Metabolic Engineering and Bioproduction
- Electrolyte and hormonal disorders
- Biofuel production and bioconversion
- Central Venous Catheters and Hemodialysis
- Bipolar Disorder and Treatment
- Enzyme Production and Characterization
- Paraquat toxicity studies and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Vascular Procedures and Complications
- Biochemical effects in animals
- Nutrition and Health in Aging
- Probiotics and Fermented Foods
- Acute Kidney Injury Research
- Potassium and Related Disorders
- Hormonal Regulation and Hypertension
- Parathyroid Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Food Quality and Safety Studies
- Chronic Kidney Disease and Diabetes
- Iron Metabolism and Disorders
- Sphingolipid Metabolism and Signaling
- Diet, Metabolism, and Disease
Hallym University Dongtan Sacred Heart Hospital
2013-2024
Hallym University
2009-2023
York University
2021
Hallym University Medical Center
2002-2018
Chuncheon Sacred Heart Hospital
2003-2013
Inha University
2008-2012
Morishita Jintan (Japan)
2011
Augsburg University
2011
University of California, Irvine
2001-2006
Hallym University Kangnam Sacred Heart Hospital
2002
Recent evidence suggests that impaired antioxidant status is involved in oxidative stress associated with diabetes. The main enzymes include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). aim of the present investigation was to evaluate activities protein expression these streptozotocin‐induced Furthermore, effects insulin therapy alone combination were studied. Male Sprague‐Dawley rats rendered diabetic by streptozotocin administration randomly assigned...
Background and aims Malnutrition inflammation are closely linked to vascular calcification (VC), the severity of which correlate with adverse outcome. However, there were few studies on interplay between malnutrition, VC progression, rather than presence per se. We aimed determine relationship inflammation, abdominal aortic (AAC) progression survival in hemodialysis (HD) patients. Methods defined as low serum albumin (< 40 g/L) high hs-CRP (≥ 28.57 nmol/L), respectively. AAC an increase...
Background In hemodialysis patients, fluid overload and malnutrition are accompanied by extracellular (ECF) expansion intracellular (ICF) depletion, respectively. We investigated the relationship between ECF/ICF ratio (as an integrated marker reflecting both malnutrition) survival cardiovascular disease (CVD) in context of malnutrition-inflammation-arteriosclerosis (MIA) complex. Methods Seventy-seven patients from a single unit were prospectively enrolled. The volume was measured segmental...
Acute renal failure (ARF) is not a rare occurrence in severe burns and an important complication leading to increase mortality. The severity of the burn largely determined by size, are likely cause enough loss extracellular fluid albumin from plasma volume produce shock hypoalbuminemia.We hypothesized that initial serum level may be useful as indicator prognosis injury burned patients.The clinical characteristics 147 adult patients with second- third-degree covering 30% or more their body...
Background. IgA nephropathy is one of the most common forms primary glomerulonephritis in adults. Its pathogenesis complex. The nature infiltrating and proliferating cells cellular mediators could contribute to progression towards end‐stage renal failure.
The aim of this study was to investigate the effects antidepressant treatment on serum cytokines and nutritional status in hemodialysis patients. Twenty-eight patients with a depressed mood were given 20 mg fluoxetine for 8 weeks. degree depressive symptoms, levels interleukin-1beta, interleukin-2, interleukin-6, tumor necrosis factor-alpha, c-reactive protein, markers assessed at baseline after treatment. outcome terms response (>50% reduction score Hamilton depression rating scale)....
In chronic hemodialysis patients, malnutrition, inflammation, depression and arteriosclerosis are pathogenetically associated suggesting the presence of malnutrition-inflammation-depression-arteriosclerosis (MIDA) complex acting as a risk factor for cardiovascular disease (CVD).Nutritional status was assessed by serum albumin, subjective global assessment normalized protein catabolic rate (nPCR). Inflammation high-sensitivity C-reactive (hsCRP). Depression with Beck Inventory DSM-IV...
The present investigation was carried out to study the expression of major cytochrome P450 (CYP) isozymes in streptozotocin-induced diabetes with concomitant insulin therapy. Male Sprague-Dawley rats were randomly assigned untreated control, diabetic, insulin-treated groups and monitored for 4 weeks. Uncontrolled hyperglycemia early phase resulted differential regulation isozymes. CYP1B1, CYP1A2, heme oxygenase (HO)-2 proteins CYP1A2-dependent 7-ethoxyresorufin O-deethylase (EROD) activity...
Atypical Hemolytic Uremic Syndrome in KoreaAtypical hemolytic uremic syndrome (aHUS) is a rare characterized by microangiopathic anemia, thrombocytopenia, and acute kidney injury.The major pathogenesis of aHUS involves dysregulation the complement system.Eculizumab, which blocks C5 activation, has recently been proven as an effective agent.Delayed diagnosis treatment can cause death or end-stage renal disease.Therefore, that differentiates from other forms thrombotic microangiopathy very...
Hyponatremia overcorrection can result in irreversible neurologic impairment such as osmotic demyelination syndrome. Few prospective studies have identified patients undergoing hypertonic saline treatment with a high risk of hyponatremia overcorrection.We conducted post hoc analysis multicenter, randomized controlled study, the SALSA trial, 178 aged above 18 years symptomatic (mean age, 73.1 years; mean serum sodium level, 118.2 mEq/L). Overcorrection was defined an increase levels by >12 or...
Abstract The causes of chronic kidney disease (CKD) affects its outcomes. However, the relative risks for adverse outcomes according to specific CKD is not well established. In a prospective cohort study from KNOW-CKD, was analyzed using overlap propensity score weighting methods. Patients were grouped into four categories cause CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive (HTN), or polycystic (PKD). From total 2070 patients, hazard ratio failure, composite...
Background/Aims Vascular access dysfunction is an important cause of morbidity and mortality in hemodialysis (HD) patients. Recent studies have shown that a klotho gene mutation related to endothelial dysfunction, thrombosis, arteriosclerosis, which are regarded as causes vascular dysfunction. We investigated the relationship between G-395A polymorphism early HD Methods Patients who underwent operations 1999 2002 were enrolled (n=126). Genotyping was performed by allelic discrimination using...
Background: Since its reemergence in 1993, a number of cases Plasmodium vivax malaria have been reported Korea. We analyzed the patients living Chuncheon and neighboring communities, to characterize clinical manifestations laboratory findings, identify any differences between our findings those previous studies. Methods: reviewed records that were confirmed as by peripheral blood smear at Sacred Heart Hospital from July 1998 September 2001. Results: Forty-four included study. All infected...
See commentary "A novel role of copeptin as a biomarker for the prediction treatment response in hyponatremia" Volume 40 on page 329.
Background: Poorly controlled longstanding diabetes frequently results in sustained hypertension (HTN) which plays a major role the pathogenesis of diabetic nephropathy. In addition, hyperglycemia, per se, causes reversible rise blood pressure (BP) and increases production reactive oxygen species (ROS). Increased ROS activity may raise BP by promoting inactivation nitric oxide (NO) and/or nonenzymatic generation vasoconstrictive prostaglandins from peroxidation arachidonic acid. Therefore,...
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into circulatory system, resulting in organ injury including acute kidney injury. We report case statin-induced rhabdomyolysis developed 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, it postulated was aggravated by full-blown rhabdomyolysis. Although...
Coronavirus disease 2019 (COVID-19) vaccines have shown excellent safety profiles.The most common short-term side effects are injection site reactions, fever, fatigue, and headache, while severe adverse reactions rarely been reported [1].However, since mass-scale vaccination began, several immune-mediated (including myocarditis de novo or relapsed glomerulonephritis [GN]) [1].COVID-19 also to induce T-cell activation [2].In this regard, the occurrence of kidney following administration a...