Cytokines are believed to have a role in the pathophysiology of major depression. The alteration levels pro-inflammatory cytokines [interleukin 1β (IL-1β), IL-2, IL-6, IL-12, interferon γ, and tumor necrosis factor α] depression supports cytokine hypothesis this illness. IL-23 IL-17 also cytokines, but few studies focused on their This study investigated potential axis depression.Plasma were measured 26 depressive disorder (MDD) patients before after 6-week treatment with antidepressants;...

Abstract During the outbreak of Middle East respiratory syndrome coronavirus(MERS-CoV) in 2015, one hemodialysis patient was infected with MERS-CoV, and remaining hemodialysis(HD) patients (n = 83) medical staff 12) had to undergo dialysis treatment an isolated environment. This study performed investigate effects stress caused by under isolation. Plasma samples from HD were collected at time isolation(M0), following month(M1), three months after isolation(M3). Parameters for included...

Abstract The correlation between the D4 dopamine receptor gene ( DRD4 ) and D2 DRD2 polymorphisms was investigated with personality traits. For this study, homogeneous population consisting of 243 young alcohol‐ drug‐naive Koreans who were blood‐unrelated a mean age (±SD) 13.87 (±0.30) years old analyzed for their trait by Temperament character inventory (TCI). association Novelty seeking (NS) score long alleles only observed among female subjects t = 2.11, P 0.037), but not in male counter...

The aim of this study was to investigate the effects antidepressant treatment on serum cytokines and nutritional status in hemodialysis patients. Twenty-eight patients with a depressed mood were given 20 mg fluoxetine for 8 weeks. degree depressive symptoms, levels interleukin-1beta, interleukin-2, interleukin-6, tumor necrosis factor-alpha, c-reactive protein, markers assessed at baseline after treatment. outcome terms response (>50% reduction score Hamilton depression rating scale)....

ABSTRACT This preliminary field trial examines the reliability and validity of a proposed research algorithm for diagnosing International Classification Diseases (ICD)‐11 personality disorders its association with other psychiatric assessments primary classification single dimension five severity levels dysfunction. In total, 137 patients (119 18 without disorders) in Korea were assessed. first part study, inter‐rater was evaluated an independent assessment (personality schedule). second (1)...

This field trial examines the discriminant validity of five trait domains originally proposed research algorithm for diagnosing International Classification Diseases (ICD)-11 personality disorders. was carried out in South Korea where a total 124 patients with disorder participated study. Participants were assessed using monothetic asocial–schizoid, antisocial–dissocial, anxious-dependent, emotionally unstable and anankastic-obsessional groups ICD-11. Their assessments compared to those from...

Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with human personality trait novelty seeking (NS). For this study, we have investigated possible association between 48-bp VNTR and -521 C/T SNP DRD4 traits among young ( approximately 14 years age) Korean female population. We found that interaction two alleles polymorphism, C/T, were significantly high on NS (F = 4.88, P 0.029) persistence (P) 5.05, 0.027) scores, suggesting variants...

Abstract Background The underlying core of personality is insufficiently assessed by any single instrument. This has led to the development instruments adapted for written records in assessment disorder. Aims To test construct validity and inter‐rater reliability a new method. Method study (four parts) Schedule Personality Assessment from Notes Documents (SPAN‐DOC), dimensional clinical records. We examined using case vignettes (Part 1) convergent three ways: comparison with NEO Five‐Factor...

Post-traumatic stress symptoms can occur in patients with medical illness. During the Middle East Respiratory Syndrome (MERS) outbreak South Korea 2015, some dialysis three centers who were incidentally exposed to or staff confirmed MERS-CoV infection isolated interrupt spread of infection. We aimed investigate post-traumatic and risk factors among these patients.In total, 116 hemodialysis (HD) contact MERS-CoV-confirmed subjects using strategies, namely, single room isolation, cohort...

Abstract If the concept of gender‐specific molecular heterosis is not considered and tested, incorrect conclusions would easily be drawn in association studies. Therein, its gender effect genetic DRD2 gene for smoking were examined with 187 healthy Korean individuals. The male smokers showed a higher A1 allele frequency ( P = 0.016) prevalence 0.049) than those non‐smokers, female lower heterozygotes 0.018) non‐smokers. However, found each disappeared when both males females as one group...

The purpose of this study was to examine the factors that predict life satisfaction in a large representative sample Koreans by analyzing data from Gallup World Poll. primary objective identify important predictors and suggest strategies improve quality Korea. used available Korean 2006 2017, which included 14,101 participants (mean age = 46.42). Predictors demographic psychological variables, with Cantril Ladder Life Scale serving as outcome variable. results show decline advancing age,...

We examined the genetic effect of DRD2 A1 allele in 167 Korean schizophrenics relation to their smoking habit. Although there was no apparent difference genotype distributions gene among female (n = 66), male counterpart 101) showed significant differences distributions. The comparison between and non-smoking patients distribution (P 0.010) with a higher prevalence 0.020) frequency heterozygotes 0.005), but not allele. A1A2 significantly rate compared A1A1 or A2A2 homozygotes male,...

본 연구는 재난 뉴스를 통한 간접 외상 노출의 심리적 영향을 살펴보기 위해 수행되었다. 참가자들(N=439)은 세월호 사건이 발생한 지 평균 68.11(±18.47)일이 경과한 후 일련의 자기 보고식 질문지를 작성하였으며, 여기에는 외상후 위기 체크리스트(Posttraumatic Risk Checklist: PRC), 사건 충격 척도(Impact of Event Scale-Revised: IES-R) 및 다차원적 죽음불안 척도(Multidimensional Fear Death Scale: MFODS)가 포함되었다. 뉴스노출과 스트레스 증상의 관계에서 죽음불안, 외상당시 위기의 매개효과를 구조방정식을 수행하였다. 그 결과, 당시 위기는 초기 증상 간의 관계를 유의하게 매개하였다. 이러한 결과는 직후의 뉴스노출이 죽음불안에 주고, 이것이 위기를 유발하며, 요인들이 증상을 증가시킬 수 있음을 의미한다. 마지막으로, 연구의 제한점과 미래 연구를 위한 제안이 논의되었다.

Easy triggering of trauma-related episodic memory fragments caused by perceptual cues is tied to strong priming in the implicit system. And among benzodiazepines, only lorazepam has been consistently reported have an atypical suppression effect on processes. The aim this study was investigate effects single doses lorazepam, diazepam, and a placebo intrusive memories after exposure distressing videotape explore whether anti-intrusive acquired as result but not conceptual processes.Under...

Personality is defined as the trait-like qualities of a person. However, it has been recently suggested that state effect situation leads to changes in scores on personality assessments. We predicted traumatic experiences would induce not only but also factor structures assessments.MethodsaaWe conducted cross-sectional, case-controlled study using two data sets: traumatized adolescent sample (n=71) and non-traumatized (n=296). were compared between samples exploratory analyses for 25...

Although diabetes mellitus (DM) is treatable, it still not curable. Its chronicity associated with a high prevalence of psychiatric disorders, especially depression in type 2 DM and learned helplessness 1 DM. In turn, this may affect patient's adherence to medical appointments, compliance treatment, effective doctor-patient relationships, which are vital promising outcomes. This study reviews the existing literature regarding interactional relationships between depression, doctor/patient...

Background: The 2014 Sewol ferry disaster is the only South Korean mass casualty incident broadcasted in real time and first instance of nation collectively experiencing a through social media. Compared to large body literature on media as stressor, its role coping tool remains underexplored.

ResultsZZSocial exclusion showed highly positive correlation with paranoid ideation, and had significant influence. Among three types of social exclusion, contempt, bullying, isolation, only isolation influence on ideation. Depression a partial mediating effect that relationship indicating affects ideation not directly, but also indirectly. On the other hand, self-esteem no moderating or effects relationship.

본 논문에서는 가시광 및 근적외선(VIS/NIR) 분광기술을 이용하여 혈란을 비파괴적으로 검출할 수 있는 측정방법을 개발하고자 하였다. 실험에 사용된 혈란 시료는 0.1 mL, 0.07 0.04 0.01 mL의 닭의 혈을 인공적으로 노른자 주변에 주입하여 제작하였다. 분석을 위해 스펙트럼 영역은 471 ~ 1154nm 이었으며, 해상도는 1.5 nm이었다. 측정을 위한 두 개 광원의 각도는 30도이었으며 광원과 시료간 거리는 100 mm로 설정하였다. 또한 열로 인해 시료가 손상되지 않도록 노출시간은 30 ms으로 측정된 스펙트럼에 부분최소자승 분류방법(PLS-DA)을 적용하여 선별모델을 개발하였다. 개발된 모델들로 분석한 결과 혈란의 선별 정확도는 mL 시료에 대해 각각 97.9%, 94.8%, 86.5% 이었다. 근적외선 기술은 이상의 혈점이 포함된 할 가능성을 보여 주었다. The aim of this study was the non-destructive...