A5017740291- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Crystallography and molecular interactions
- Carbohydrate Chemistry and Synthesis
- Chemical synthesis and alkaloids
- Synthesis of Indole Derivatives
- Axial and Atropisomeric Chirality Synthesis
- Nutrition, Health and Food Behavior
- Oxidative Organic Chemistry Reactions
- Synthesis and Reactions of Organic Compounds
- Alcohol Consumption and Health Effects
- Advanced Synthetic Organic Chemistry
- GABA and Rice Research
- Synthesis and Biological Activity
Kyonggi University
2016-2025
Juntendo University Nerima Hospital
2012-2025
Juntendo University
2002-2025
Pusan National University Yangsan Hospital
2013-2022
Pusan National University
2008-2022
Juntendo University Hospital
2022
Sartorius (United States)
2019
Suwon Research Institute
2017
Government of the Republic of Korea
2017
Pohang University of Science and Technology
1997-2010
Mechanical stretch affects the healing and remodeling process of anterior cruciate ligament (ACL) after surgery in important ways. In this study, effects mechanical stress on gene expression type I III collagen by cultured human ACL cells roles transforming growth factor (TGF)-beta1 regulation strain-induced were investigated. Uniaxial cyclic was applied at 10 cycles/min with 10% length for 24 h. mRNA increased stretch. TGF-beta1 protein cell culture supernatant also presence anti-TGF-beta1...
The enantiomeric recognition of alpha-chiral primary ammonium ions has been studied with benzene-based tripodal tris(oxazoline) receptors. Contrary to the literature and our expectation, a good level chiral discrimination is observed one receptors, which provides C3-symmetric environment on guest binding. found be general in case alpha-aryl substituted guests, suggesting pi-pi interactions as an important factor. This result raises question respect origin since little steric or electronic...
Look again: Highlights of the 20-step synthesis callipeltoside C include proline-catalyzed direct aldol reaction, enantioselective α-oxyamination and rapid access to carbohydrate framework using a de novo protocol. Based on this work previously assigned absolute configuration pendent 2-O-methylevalose unit has been revised.
Although anterior cruciate ligament (ACL) reconstruction techniques that preserve remnant tissues have been described, complete preservation may be difficult, with little known about its clinical advantages.To compare outcomes in patients undergoing ACL and without preservation.Case-control study.Of 372 who underwent surgical treatment of an injury between September 2006 July 2010, 154 had no remaining identifiable tissue were excluded from this study. Attempts made to the as much possible...
The enantio-discrimination of β-chiral primary ammonium ions is achieved by a rational approach that utilizes three-center (bifurcated) hydrogen bonding. extraction experiments on various selected guests reveal the bifurcated H-bonding plays crucial role for chiral discrimination. X-ray data obtained an inclusion complex substantiate such interactions. Using H-bonding, molecular recognition with our C3-symmetric tripodal oxazoline receptors extended generally toward α-, β-, and α,β-chiral...
Background: The functional polymorphism (A118G) of the μ‐opioid receptor gene ( OPRM1 ) is thought to have clinical significance in treatment alcohol dependence. This study compared Koreans with one or two copies A118G seeking for dependence a group non–alcohol‐dependent controls. Methods: Patients hospitalized n = 112) and controls 140) were interviewed on aspects drinking history psychiatric history. excluded if they met criteria any other major disorder. Participants genotyped at locus....
Internal fixation is advocated as the primary treatment for fifth metatarsal Jones fractures in athletes; however, screw insertion site discomfort and refracture can occur especially competitive athletes. The ideal implant has not been determined.Headless compression of proximal an effective approach athletes.Case series; Evidence level, 4.We studied 60 athletes treated surgically with a headless (mean age, 19 years). mean follow-up time was 178 weeks. We evaluated clinical radiographic...
A highly efficient asymmetric [3+2] and [4+2]-annulation of cyclic N -sulfonyl ketimines with γ- or δ-hydroxy-α,β-unsaturated ketones has been developed.
A highly efficient enantioselective Michael addition of cyclic N-sulfonylimines with nitroalkenes has been developed, utilizing a bifunctional squaramide catalyst. This approach achieves remarkable results, delivering products high yields and outstanding stereoselectivities, reaching up to 97% yield, >20:1 dr, >99% ee. Furthermore, an asymmetric tandem reaction 2-nitroallylic acetates established. innovative methodology involves Michael/intramolecular aza-Michael cascade, leading the...
The [4 + 2]-cycloaddition reaction between cyclic N-sulfonyl ketimines and 2-aminophenyl enones, catalyzed by K2CO3, has been developed. This method provides a straightforward efficient approach for synthesizing wide range of structurally complex highly functionalized benzosultam-fused tetrahydroquinazolines in high yields, with excellent diastereoselectivities.
A highly novel method for the preparation of benzyl 2-phenyl-1H-pyrrole-1-carboxylate has been developed. The intramolecular reaction (E)-(4-oxo-4-phenylbut-2-en-1-yl)carbamate with oxalyl chloride provided title compound in good yields. structure newly synthesized was determined using 1H-, 13C-NMR, IR, and mass spectral data.
Abstract The asymmetric organocatalytic conjugate addition–cyclization reaction of malonates with o ‐hydroxycinnamaldehydes, which affords 4‐substituted chroman‐2‐ols, has been established using a diphenylprolinol trimethylsilyl (TMS) ether as organocatalyst. desired products were obtained good to excellent yields and high enantioselectivities (up >99% ee ). Synthetically useful chroman derivatives formed after subsequent reactions.
Athletes suffering from any injuries want to know when they will be able return sports activity. The period of return-to-sport after the arthroscopic meniscectomy is still unknown. aim this study investigate surgery and clinical symptoms on stable knees. Fifty-six athletes who underwent were evaluated. patients with an average age 26.7 years (range, 13–67) comprised 45 men 11 women, 16 medial meniscus 40 lateral injuries. follow-up was 9.2 months. parameter examined age, injured side (medial...
An organocatalytic enantioselective Michael addition/aza-cyclization cascade reaction of aldehydes with 2-amino-β-nitrostyrenes has been developed for the construction fully substituted chiral tetrahydroquinolines. The reaction, promoted by diphenylprolinol TMS ether as an organocatalyst, generated tetrahydroquinolines in good to high yield excellent diastereo- and enantioselectivities (up >30:1 dr, >99% ee). method also provided alternative access 1,4-dihydroquinolines, which are difficult...
Abstract A synthetic method for the construction of fully substituted enantioenriched 1,4‐dihydroquinolines using an organocatalytic aza‐Michael/Michael cascade reaction has been developed. The asymmetric 2‐(tosylamino)phenyl α,β‐unsaturated ketones with alkynyl aldehydes, promoted by diphenylprolinol O ‐TMS ether as organocatalyst, generated chiral in good to high yields excellent enantioselectivities (up 97 % ee ). magnified image
Catalyst-free and mild synthetic methods for the construction of hindered α-amino acid derivatives are presented herein. A wide range amino amides can be readily obtained from reaction α-halohydroxamates with a variety amines, including anilines, primary secondary amines. Moreover, aza/aza-[4+3] cycloaddition in situ-generated aza-oxyallyl cations 2-aminophenyl α,β-unsaturated carbonyls to furnish seven-membered benzodiazepin-3-ones is reported first time.
Abstract The first organocatalytic asymmetric [4+3]‐cycloaddition of 2‐aminophenyl α,β‐unsaturated carbonyls with in situ generated azaoxyallyl cations was developed, and enantioenriched functionalized seven‐membered 1,4‐benzodiazepine‐3‐ones were obtained good yields excellent enantioselectivities. This approach also extended to the δ‐hydroxy carbonyls, affording 1,4‐oxazepanes one step under mild conditions. Several novel adducts demonstrated promising bioactivity prevention peripheral...
A highly efficient enantioselective [4 + 2] cycloaddition of 2-amino-β-nitrostyrenes with cyclic N-sulfonyl ketimines has been developed. This reaction utilizes an organocatalytic approach, employing a multiple-hydrogen-bonding bifunctional squaramide-based catalyst. The process allows for the precise synthesis chiral polycyclic benzosultams, showcasing intricate structures that incorporate quaternary centers. Noteworthy outcomes this method include high yields excellent enantioselectivities...