A5079635056- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Bone and Joint Diseases
- Lower Extremity Biomechanics and Pathologies
- Inflammatory mediators and NSAID effects
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Shoulder Injury and Treatment
- Bone health and treatments
- Proteoglycans and glycosaminoglycans research
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Sports injuries and prevention
- Hip disorders and treatments
- Musculoskeletal pain and rehabilitation
- Periodontal Regeneration and Treatments
- Bone health and osteoporosis research
- Healthcare and Venom Research
- Spondyloarthritis Studies and Treatments
- Infrared Thermography in Medicine
- Bone fractures and treatments
- Mesenchymal stem cell research
- Schizophrenia research and treatment
- Cell Adhesion Molecules Research
Juntendo University
2016-2025
Juntendo University Hospital
2013-2024
Nagasaki University
2021-2023
Japan Research Institute
2023
RIKEN Center for Integrative Medical Sciences
2023
National Center for Geriatrics and Gerontology
2023
Shimane University
2023
Institute of Neurobiology
2020
Japan Sport Council
2020
Fukushima Medical University
2010-2019
Abstract Mechanical stress and aging are major risk factors of cartilage degeneration. Human studies have previously reported that oxidative damage increased, while SOD2 protein was reciprocally downregulated in osteoarthritic degenerated cartilage. However, it remains unclear whether mitochondrial superoxide imbalance chondrocytes causes We herein demonstrate mechanical loading promoted generation selective Sod2 downregulation vivo inducer also expression vitro . A genetically manipulated...
We tested the hypothesis that there exist relationships between onset of early stage radiographically defined knee osteoarthritis (OA), pain and changes in biomarkers joint metabolism. Using Kellgren-Lawrence (K/L) grading radiographic OA (K/L 2) was detected 16 46 patients. These grades 1 is no K/L 2 OA) were divided into two groups according to presence or absence persistent pain. Sera (s) urines (u) analysed with for cartilage collagen cleavage (sC2C uCTX-II) synthesis (sCPII), bone...
The human synovium contains mesenchymal stem cells (MSCs), which are multipotential non-hematopoietic progenitor that can differentiate into a variety of lineages and they may therefore be candidate cell source for tissue repair. However, the molecular mechanisms by this occur still largely unknown. Mouse primary culture enables us to investigate underlying various phenomena because it allows relatively easy gene manipulation, is indispensable analysis. mouse synovial (SMCs) have not been...
<h3>Background/aims</h3> New human adenovirus (HAdV)-54 causes epidemic keratoconjunctivitis (EKC) and is virologically close to has occasionally been detected as HAdV-8. Taking HAdV-54 into account, we re-determined HAdV type in EKC samples determine its epidemiology Japan, examined the virological features of HAdV-54. <h3>Methods</h3> was 776 conjunctival swabs from Japan 174 six other countries, obtained between 2000 2009. Using 115 strains before 1999, trends regarding HAdV-8 were also...
Medial meniscal extrusion (MME) is associated with progression of medial knee osteoarthritis (OA), but no or little information available for relationships between MME and osteophytes, which are found in cartilage bone parts. Because the limitation detectability part osteophytes by radiography conventional magnetic resonance imaging (MRI), rate development size appear to have been underestimated. T2 mapping MRI may enable us evaluate we aimed examine association OA-related changes, including...
Although anterior cruciate ligament (ACL) reconstruction techniques that preserve remnant tissues have been described, complete preservation may be difficult, with little known about its clinical advantages.To compare outcomes in patients undergoing ACL and without preservation.Case-control study.Of 372 who underwent surgical treatment of an injury between September 2006 July 2010, 154 had no remaining identifiable tissue were excluded from this study. Attempts made to the as much possible...
We previously reported that perlecan, a heparan-sulfate proteoglycan (Hspg2), expressed in the synovium at cartilage-synovial junction, is required for osteophyte formation knee osteoarthritis. To examine mechanism underlying this process, we examined role of perlecan proliferation and differentiation synovial mesenchymal cells (SMCs), using recently established mouse cell culture method. Primary SMCs isolated from Hspg2-/- -Tg (Hspg2-/- ;Col2a1-Hspg2Tg/- ) mice, which perlecan-knockout was...
Abstract Background and purpose Psychological factors including fear of pain, re-injury during movement (kinesiophbia) affect return-to-sport rates after anterior cruciate ligament (ACL) reconstructive surgery. Clinicians often encounter in the daily practice that athletes explain lack self-confidence or psychological readiness sports activity. The Tampa Scale for Kinesiophobia (TSK) has been used to evaluate outcomes patients with ACL injuries many countries translated into Japanese version...
Osteophytes contribute to the development and progression of knee osteoarthritis (OA). Although transforming growth factor-β (TGFβ) bone morphogenic protein-2 (BMP2) are known induce osteophytes, regulators osteophyte formation remain elusive. This study aimed search for molecules that modulate osteophytosis in a mouse OA model. Proteomic analysis followed by immunohistochemistry articular cartilage identified heat shock protein 47 (HSP47), molecular chaperone procollagens, as molecule...