A5060316688- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Allergic Rhinitis and Sensitization
- Corneal surgery and disorders
- Ocular Infections and Treatments
- Urticaria and Related Conditions
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Herpesvirus Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Ophthalmology and Eye Disorders
- Virus-based gene therapy research
- Air Quality and Health Impacts
- Circadian rhythm and melatonin
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Rabies epidemiology and control
- Renal Transplantation Outcomes and Treatments
- Mast cells and histamine
- Pituitary Gland Disorders and Treatments
- Advancements in Transdermal Drug Delivery
- Chemokine receptors and signaling
- Acne and Rosacea Treatments and Effects
Akebono Clinic
2010-2022
Kyoto University Hospital
2014
Eye Center
2008
Ehime University
1998-2004
Massachusetts Eye and Ear Infirmary
1997-2000
Harvard University
1997-2000
Smith-Kettlewell Eye Research Institute
1995-2000
Okayama University
2000
Osaka University
1991-1995
University of Miami
1994
To examine the efficacy of tacrolimus ophthalmic suspension 0.1% in treating severe allergic conjunctivitis.This was a multicenter, randomized, double-masked, placebo-controlled clinical trial. Fifty-six patients with conjunctivitis whom topical antiallergic agents and corticosteroids had been ineffective were randomized to or placebo treatment. Patients treated either twice-daily for 4 weeks. Severity objective signs palpebral bulbar conjunctiva, limbus, corneal involvement assessed using...
<h3>Background</h3> The objective of this study was to investigate the efficacy topical 0.1% tacrolimus in treating refractory allergic conjunctivitis with proliferative lesions and/or corneal involvement. <h3>Methods</h3> This prospective observational included 1436 patients whose condition had responded poorly conventional antiallergic drugs steroids cyclosporine. All received eye drops twice daily during period. Ten clinical signs and six symptoms were rated on a four-grade scale. primary...
Purpose: To evaluate the effectiveness and safety of a novel cyclosporine 0.1% aqueous ophthalmic solution in large population with vernal keratoconjunctivitis (VKC) atopic (AKC). Methods: A prospective observational postmarketing study was initiated Japan. total 594 patients VKC or AKC were started on this drug within 1 year after market launch (January 2006) completed 6-month follow-up. These observed clinically, subjective ocular symptoms (itching, discharge, tearing, photophobia, foreign...
Abstract Ambient air pollution is a well-recognized risk for various diseases including asthma and heart diseases. However, it remains unclear whether may also be of ocular allergic Using web-based, nation-wide, cross-sectional study design, we examined the level ambient significantly associated with prevalence A web-based questionnaire was posted to invite participants who are members Japan Ophthalmologist Association their family members. The answers from 3004 respondents were used...
The definition, classification, pathogenesis, test methods, clinical findings, criteria for diagnosis, and therapies of allergic conjunctival disease are summarized based on the Guidelines Clinical Management Allergic Conjunctival Disease 2019. is defined as "a inflammatory associated with a Type I allergy accompanied by some subjective or objective symptoms." classified into conjunctivitis, atopic keratoconjunctivitis, vernal giant papillary conjunctivitis. Representative symptoms include...
<h3>Background/aims</h3> New human adenovirus (HAdV)-54 causes epidemic keratoconjunctivitis (EKC) and is virologically close to has occasionally been detected as HAdV-8. Taking HAdV-54 into account, we re-determined HAdV type in EKC samples determine its epidemiology Japan, examined the virological features of HAdV-54. <h3>Methods</h3> was 776 conjunctival swabs from Japan 174 six other countries, obtained between 2000 2009. Using 115 strains before 1999, trends regarding HAdV-8 were also...
To evaluate the effects of 0.1% topical tacrolimus alone or in combination with steroids for treatment shield ulcers and corneal epitheliopathy patients refractory allergic ocular diseases.Open cohort study.Patients conjunctivitis epitheliopathy, ulcers, plaques (N = 791).The 791 were treated oral steroids. The effectiveness treatments was determined by a score during 3-month follow-up period. clinical signs rated on 4-grade scale. Corneal no staining graded as 0, 3, highest grade. without...
Abstract Immune privilege in the anterior chamber of eye results part from a selective deficit delayed hypersensitivity that is elicited by antigenic materials placed this unique tissue site. This distinctive systemic immune response to intraocular Ag (termed chamber-associated deviation, ACAID) fashioned indigenous, bone marrow-derived cells capture within and carry an Ag-specific ACAID-inducing signal via blood directly spleen. An identical form deviation can be evoked i.v. injection...
To review our previous studies regarding the development of a tear stability analysis system (TSAS) using videokeratography and clinical application TSAS for evaluation film in patients subject to laser situ keratomileusis (LASIK).New software, namely TSAS, was developed TMS-2N (topographic modeling system). automatically captures consecutive corneal surface images every second 10 seconds. Corneal topographs were analyzed breakup time (TMS-BUT) area (TMS-BUA, ratio entire color-code area)....
To estimate the efficacy and safety of 0.1% tacrolimus ophthalmic suspension based on blood level in patients with severe allergic conjunctivitis.Fifty-two whom topical anti-allergic agents had been ineffective were treated twice daily for 12 weeks. Adverse drug reactions monitored, as well ocular symptoms signs. The concentration was measured before initiation treatment 4 weeks later.About 75% without concomitant using ointment levels below detection limit assay (0.5ng/mL). On other hand,...
Abstract Delayed hypersensitivity (DH) is an important immune effector modality that successfully wards off intracellular pathogens and many parasites, but also causes immunopathogenic injury to vital tissues. Particularly in the eye, DH has devastating effects can lead blindness. Ags injected into anterior chamber of eye naive mice elicit a deviant form systemic immunity which selectively down-regulated. Expression this model system curtailed by regulatory CD8+ T cells. At present, we have...
Purpose: To compare refractive outcomes of myopic LASIK with centration on the coaxially sighted corneal light reflex (CSCLR) to center pupil (line sight [LOS]). Methods: The NIDEK CXIII excimer laser was used treat 268 eyes CSCLR (CSCLR group) and 288 LOS (LOS group). For group, ablation delivered 80% closer visual axis. One-month postoperative were compared. Results: Preoperative manifest refraction spherical equivalent (MRSE) −4.88±1.55 diopters (D) (range: −8.50 −1.25 D) in group...
Purpose/Aim: This study evaluated the efficacy of topical 0.1% tacrolimus ophthalmic suspension for treating chronic allergic conjunctival disease with and without atopic dermatitis.Materials Methods: was conducted as a prospective observational post-market survey. Our large-scale protocol accepted by Pharmaceuticals Medical Devices Agency in Japan included patients who were prescribed treatment from May 2008 to Aug 2010 Japan. Topical instilled 2 times daily 6 months. The primary endpoint...
PURPOSE. To examine the effect of donor-specific anterior chamber-associated immune deviation (ACAID) induction on survival orthotopic corneal allografts in neovascularized graft beds. METHODS. induce ACAID recipients, peritoneal exudate cells (PEC) from C57BL/6 mice were incubated overnight with transforming growth factor (TGF)-ß. Cultured PEC injected intravenously (iv) into BALB/c mice, and, 1 week later, these animals received donors Control iv injection syngeneic (BALB/c) PEC, cultured...
To compare refractive outcomes, higher-order aberrations (HOAs), and contrast sensitivity of myopic wavefront-guided aspheric laser in situ keratomileusis centered on the coaxially sighted corneal light reflex or line sight.Okamoto Eye Clinic, Ehime, Japan.Comparative case series.Data at 3 months were compared based distance between sight (P-distance) as follows: greater than 0.25 mm (high-distance group), 0.15 less (intermediate-distance (low group).The chart review included 317 eyes...
To determine the association of KL-6 epitope (sugar moiety) with MUC1 and its distribution on ocular surface human non-dry dry eyes.The was examined immunohistochemically immunoelectron microscopically using monoclonal antibody (mAb) KL-6, which recognize a carbohydrate MUC1. The expression patterns in corneal conjunctival cells were by impression cytology from 24 eye volunteers 43 dry-eye patients.In cornea, bulbar conjunctiva, limbus epithelium, mAb reacted to apical cell membrane...