A5003291341- Genetic and Environmental Crop Studies
- Liver Disease Diagnosis and Treatment
- Agricultural pest management studies
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Peroxisome Proliferator-Activated Receptors
- Reproductive Biology and Fertility
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Renal and related cancers
- MicroRNA in disease regulation
- Bone and Joint Diseases
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Plant Genetic and Mutation Studies
- Cholesterol and Lipid Metabolism
- Blood disorders and treatments
- Sperm and Testicular Function
- Lipid metabolism and biosynthesis
- TGF-β signaling in diseases
- Histone Deacetylase Inhibitors Research
- Botanical Studies and Applications
- Immune cells in cancer
The People's Hospital of Guangxi Zhuang Autonomous Region
2012-2025
Fudan University
2024
Karolinska Institutet
2014-2023
BGI Group (China)
2023
Fuyang City People's Hospital
2020
Guangxi Medical University
2020
Xiangya Hospital Central South University
2019
Central South University
2019
Metabiota (United States)
2018
Juntendo University
2010-2015
Abstract Background MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are indicated to play essential roles in spermatogenesis. However, little is known about the expression patterns or function miRNAs human testes involved infertility. Methods In this study, miRNA profiles patients with non-obstructive azoospermia (NOA) and normal controls were performed by using microarray technologies. Results Altered microRNA NOA was found, 154 differentially down-regulated 19 up-regulated...
Estrogen receptor α (ERα) is initially expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression by regulating transcription genes linked to cell proliferation. ERα status clinical importance, as ERα-positive can be successfully treated adjuvant therapy with antiestrogens or aromatase inhibitors. Complications arise from frequent development drug resistance that might caused multiple alterations, including components signaling, during tumor metastasis....
Non-alcoholic fatty liver disease (NAFLD) is a very common indication for transplantation. How fat-rich diets promote progression from to more damaging inflammatory and fibrotic stages poorly understood. Here, we show that disrupting phosphorylation at Ser196 (S196A) in the X receptor alpha (LXRα, NR1H3) retards NAFLD mice on high-fat-high-cholesterol diet. Mechanistically, this explained by key histone acetylation (H3K27) transcriptional changes pro-fibrotic pro-inflammatory genes....
Warm ambient conditions induce thermomorphogenesis and affect plant growth development. However, the chromatin regulatory mechanisms involved in remain largely obscure. In this study, we show that histone methylation readers MORF-related gene 1 2 (MRG1/2) are required to promote hypocotyl elongation response warm conditions. A transcriptome sequencing analysis indicates MRG1/2 phytochrome interacting factor 4 (PIF4) coactivate a number of thermoresponsive genes, including YUCCA8, which...
Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit nuclear receptor corepressor (NCOR) histone deacetylase 3 (HDAC3) complex, has central role these accelerates progression NAFLD towards steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout mice alleviates diet-induced steatosis fibrosis causes...
While the role of transcription factors and coactivators in controlling enhancer activity chromatin structure linked to gene expression is well established, involvement corepressors not. Using inflammatory macrophage activation as a model, we investigate here corepressor complex containing GPS2 SMRT both genome-wide at Ccl2 locus, encoding chemokine CCL2 (MCP-1). We report that co-occupy candidate enhancers along with CBP (H3K27 acetylase) MED1 (mediator) but act antagonistically by...
Lung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs), but growing evidence indicates that transcriptional programs beyond HIFs control tumor angiogenesis. Here, we show the redox-sensitive factor BTB and CNC homology 1 (BACH1) controls of broad range angiogenesis genes. BACH1 stabilized lowering ROS levels; consequently, gene expression in lung cells, organoids, xenograft tumors increased...
Hypertrophic white adipose tissue (WAT) represents a maladaptive mechanism linked to the risk for developing type 2 diabetes in humans. However, molecular events that predispose WAT hypertrophy are poorly defined. Here, we demonstrate adipocyte is triggered by loss of corepressor GPS2 during obesity. Adipocyte-specific deficiency mice (GPS2 AKO) causes hypertrophy, inflammation, and mitochondrial dysfunction surplus energy. This phenotype driven HIF1A activation orchestrates inadequate...
Ethnic minority groups are particularly vulnerable to healthcare inequities, with catastrophic medical expenditures often pushing them into poverty. However, empirical research on the impact of reforms these populations remains limited. This study aims address this gap by exploring effects payment outcomes and financial protection during serious illnesses among ethnic populations. A cross-sectional was conducted using data from three major in China: Zhuang, Hui, Manchu. The analysis is based...
The TGF-β superfamily members are indicated to play key roles in ovarian follicular development, such as granulosa cell proliferation, estrogens, and progesterone production. However, little is known about the of TGF-β3 development. In this study, we found that was predominantly expressed cells mouse follicles, it significantly promoted 17β-estradiol (E2) release a dose-dependent manner. orphan nuclear receptor steroidogenic factor-1 (SF-1) required TGF-β3-induced Cyp19a1 (a rate-limiting...
To elucidate the role of perlecan (Hspg2), a large multidomain heparan sulfate proteoglycan expressed in basement membrane, structure corneal epithelium.A previously developed perlecan-deficient (Hspg2⁻/⁻-Tg) mouse model was used. Histologic analysis their corneas performed by light and transmission electron microscopy. The localization wild-type (WT) mice Hspg2⁻/⁻-Tg examined immunohistochemistry. effects deficiency on epithelial analyzed with respect to expression proliferation...
Laminin α1 (LAMA1), a subunit of the laminin-111 basement membrane component, has been implicated in various biological functions vivo and vitro. Although LAMA1 is present kidney, its roles kidney are unknown because early embryonic lethality. Herein, we used viable conditional knockout mouse model with deletion Lama1 epiblast lineage (Lama1(CKO)) to study role development function. Adult Lama1(CKO) mice developed focal glomerulosclerosis proteinuria age. In addition, mesangial cell...
Abstract The Th2 cytokine interleukin 4 (IL4) promotes macrophage differentiation into alternative subtypes and plays important roles in physiology, metabolic inflammatory diseases, cancer tissue regeneration. While the regulatory transcription factor networks governing IL4 signaling are already well-characterized, it is currently less understood which transcriptional coregulators involved how they operate mechanistically. In this study, we discover that G protein pathway suppressor 2...
The NXF (nuclear export factor) family members are implicated in the transport of mRNA from nucleus to cytoplasm. Recently, some have been reported play divergent functional roles, such as post-transcriptional regulation, translational control, regulation stability and trafficking. However, little is known about roles NXF3 spermatogenesis. In present study, we found that mouse NXF3, specifically expressed principal cells segment II caput epididymis, well Sertoli testis, was required mediate...
Macrophages play important roles in linking alterations of cholesterol metabolism and inflammation to the development atherosclerosis. Previous studies have identified several positive negative crosstalk mechanisms that connect efflux at transcriptional level. Of particular relevance is expression ATP-binding cassette transporter A1 (Abca1), a main regulator efflux, can be induced by oxysterol receptor LXR agonists but also bacterial endotoxins, such as LPS, activate TLR4 signaling. However,...
We report on a study conducted in Guangdong Province, China, to characterize behaviors and perceptions associated with transmission of pathogens pandemic potential highly exposed human populations at the animal-human interface. A risk factor/exposure survey was administered individuals high levels exposure wildlife. Serological testing performed evaluate prior infection several wildlife viral pathogens. Follow up serology subset cohort as well close contacts individuals. 1,312 were enrolled...
Intra-abdominal pregnancy is rare and affects approximately 1 in 10,000 births. It occurs 1.4% of ectopic pregnancies carries a mortality rate 5.1/1000 cases, 7.7 times higher compared with nonabdominal pregnancies. This study aimed to present case live 14-week primary hepatic diagnosed using ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) managed laparoscopic microsurgery. A 21-year-old Chinese female patient, who had never been married pregnant, was 14 weeks pregnant...