A5010581492- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Peroxisome Proliferator-Activated Receptors
- HER2/EGFR in Cancer Research
- Nonmelanoma Skin Cancer Studies
- Circadian rhythm and melatonin
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Drug Transport and Resistance Mechanisms
- Dietary Effects on Health
- Monoclonal and Polyclonal Antibodies Research
- Spaceflight effects on biology
- Cutaneous Melanoma Detection and Management
- Cancer, Lipids, and Metabolism
- Thyroid Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Receptor Mechanisms and Signaling
- Sphingolipid Metabolism and Signaling
- Genomics and Chromatin Dynamics
- Growth Hormone and Insulin-like Growth Factors
- interferon and immune responses
- Protein Kinase Regulation and GTPase Signaling
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
Karolinska Institutet
2009-2023
Karolinska University Hospital
2015-2017
Svenska Örtmedicinska Institute
2013
The oxysterol receptors [liver X (LXRα and LXRβ)] regulate cholesterol lipid biosynthesis several studies link dysregulation of these metabolic pathways to aberrant cell growth. Here, we show that activation LXR significantly reduced proliferation in human breast cancer cells lines. suppressed messenger RNA and/or protein expression Skp2, cyclin A2, D1 estrogen receptor (ER) α, whereas it increased the p53 at level maintained retinoblastoma a hypophosphorylated active form. These changes may...
Abstract The oxysterol receptors LXRα and LXRβ are members of the nuclear receptor family established transcriptional regulators lipid metabolism with additional anti‐inflammatory functions. Recent investigations have indicated an important role LXRs in control proliferation. Here we further extend this knowledge to human colon cancer cells proliferation mouse colon. We show that activation leads a robust cell cycle arrest colorectal adenocarcinoma lines. At molecular level expression...
Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit nuclear receptor corepressor (NCOR) histone deacetylase 3 (HDAC3) complex, has central role these accelerates progression NAFLD towards steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout mice alleviates diet-induced steatosis fibrosis causes...
The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, potential feedback peripheral signals remains poorly characterized. To explore whether organ clocks may affect pacemaker, we used chimeric model which mouse hepatocytes were replaced by human hepatocytes. Liver humanization led to reprogrammed diurnal gene expression and advanced phase liver that extended muscle entire rhythmic physiology. Similar clock-deficient mice,...
Sterol O-acyltransferase 2 (Soat2) encodes acyl-coenzyme A:cholesterol acyltransferase (ACAT2), which synthesizes cholesteryl esters in hepatocytes and enterocytes fated either to storage or secretion into nascent triglyceride-rich lipoproteins.We aimed unravel the molecular mechanisms leading reduced hepatic steatosis when Soat2 is depleted mice.Soat2-/- wild-type mice were fed a high-fat, high-carbohydrate, chow diet, parameters of lipid glucose metabolism assessed.Glucose, insulin,...
Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose fatty acid metabolism. The antiproliferative role LXRs has been studied a variety malignancies may represent therapeutic opportunity cancers lacking targeted therapies, such as triple‐negative breast cancer. In this study, we investigated impact LXR agonists alone combination with carboplatin preclinical models vitro experiments revealed dose‐dependent decrease tumor...
Abstract Pancreatic cancer is the fourth leading cause of deaths in US and has worst prognosis major cancers due to difficulties early detection limited treatment options. Nuclear receptors (NRs) are a family ligand-dependent transcription factors which play key roles regulating gene expression normal development physiology number human diseases, including cancers. These their ligands involved breast prostate cancers, they have been successfully targeted clinically prevention these diseases....
ABSTRACT The circadian clock is an evolutionarily acquired gene network that synchronizes physiological processes to adapt homeostasis the succession of day and night. While most mammalian cells have a clock, their synchronization at body-level depends on central pacemaker located in suprachiasmatic nuclei hypothalamus integrates light signals. However, peripheral organs are also synchronized by feeding cues can uncoupled them from pacemaker. Nevertheless, potential feedback signals remains...