A5022370468- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Cardiovascular Disease and Adiposity
- Pregnancy-related medical research
- Nutrition, Genetics, and Disease
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Bone fractures and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Prostate Cancer Treatment and Research
- Muscle Physiology and Disorders
- Sirtuins and Resveratrol in Medicine
Karolinska Institutet
2018-2025
University of Milan
2016
Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit nuclear receptor corepressor (NCOR) histone deacetylase 3 (HDAC3) complex, has central role these accelerates progression NAFLD towards steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout mice alleviates diet-induced steatosis fibrosis causes...
Hypertrophic white adipose tissue (WAT) represents a maladaptive mechanism linked to the risk for developing type 2 diabetes in humans. However, molecular events that predispose WAT hypertrophy are poorly defined. Here, we demonstrate adipocyte is triggered by loss of corepressor GPS2 during obesity. Adipocyte-specific deficiency mice (GPS2 AKO) causes hypertrophy, inflammation, and mitochondrial dysfunction surplus energy. This phenotype driven HIF1A activation orchestrates inadequate...
Genome-wide association studies [GWAS] have identified a limited number of endometrial cancer risk loci by analyzing single nucleotide polymorphisms [SNPs]. We hypothesized that haplotypes rather than SNPs could provide novel and more detailed information on genetic susceptibility loci. To examine the SNP or haplotype with we performed two-stage GWAS. The discovery GWAS included sub-cohort 1,116 Swedish cases 5,021 controls from previously published data. A sliding window analysis was...
Glucose homeostasis is maintained through organ crosstalk that regulates secretion of insulin to keep blood glucose levels within a physiological range. In type 2 diabetes, this coordinated response altered, leading deregulation beta cell function and inadequate secretion. Reprogramming white adipose tissue has central role in deregulation, but the critical regulatory components remain unclear. Here, we demonstrate expression transcriptional coregulator GPS2 correlated with rate humans. The...
Adipogenesis is critical for adipose tissue remodeling during the development of obesity. While role transcription factors in orchestration adipogenic pathways already established, involvement coregulators that transduce regulatory signals into epigenome alterations and transcriptional responses remains poorly understood. The aim our study was to investigate which are controlled by G protein pathway suppressor 2 (GPS2) differentiation human adipocytes. We generated a unique loss-of-function...
Prostate cancer is the most prevalent in men worldwide. It a polygenic disease with substantial proportion of heritability. Identification novel candidate biomarkers crucial for clinical prevention and development therapeutic strategies. Here, we describe analysis rare common genetic variants that can predispose to prostate cancer. Whole-genome sequencing was performed on germline DNA five Swedish siblings which were diagnosed The high-risk identified setting minor allele frequency < 0.01,...