A5072763058- Spondyloarthritis Studies and Treatments
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Global Cancer Incidence and Screening
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Colorectal Cancer Screening and Detection
- Cancer-related Molecular Pathways
- Multiple and Secondary Primary Cancers
- Rheumatoid Arthritis Research and Therapies
- NF-κB Signaling Pathways
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Hepatitis B Virus Studies
- Medical Research and Treatments
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
Children's Hospital of Zhejiang University
2025
Children's Clinical University Hospital
2025
Zhejiang University
2025
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2025
Second Hospital of Shandong University
2021-2024
China Medical University
2014-2024
Qidong Liver Cancer Prevention Research
2006-2023
Soochow University
2012-2023
Shandong University
2008-2022
The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss function can impair p53-mediated cell cycle arrest apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region pri-miR-34b/c (423 bp from transcription start site), located CpG island might affect factor GATA binding therefore expression. In our study, we hypothesized that SNPs miR-34b/c TP53 Arg72Pro may independently or jointly contribute to primary hepatocellular...
Neonatal hepatitis B vaccination has been implemented worldwide to prevent virus (HBV) infections. Its long-term protective efficacy on primary liver cancer (PLC) and other diseases not fully examined.The Qidong Hepatitis Intervention Study, a population-based, cluster randomized, controlled trial between 1985 1990 in Qidong, China, included 39,292 newborns who were randomly assigned the group which 38,366 participants completed HBV series 34,441 control received neither vaccine nor placebo....
To investigate the correlation between enhancement patterns and parameters of contrast material-enhanced ultrasonography (US) with prognostic factors in breast cancers.The study was approved by institutional ethics committee, written informed consent obtained. Surgical resection specimens 74 malignant lesions women (mean age, 55 years; age range, 32-78 years) who had undergone contrast-enhanced US were included. Different (enhancement degree, order, margin; internal homogeneity; perfusion...
High levels of SOX2 protein are correlated with increased dissemination breast cancer. However, the underlying molecular mechanisms not fully understood. In this study we investigate role in cancer metastasis using multiple vitro and vivo assays including cell culture, shRNA-mediated knockdown, wound healing, colony formation, transwell chamber, xenograft tail vein injection. Moreover, western blot, immunostaining, microarray real-time PCR were used to determine change miRNA levels....
A population-based cancer registry was established in Qidong, Jiangsu Province, China, 1972, and the trends incidence rates of major sites have been analyzed for a 25-year period, 1978-2002. Five-year age-specific rates, crude world age-standardized (ASR), percent change (PC) annual (APC) were calculated using data on population size, estimates its age structure. The indices histological verification diagnosis, death certificate only proportion mortality to employed assessing registration...
Estrogen receptor α (ERα) is initially expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression by regulating transcription genes linked to cell proliferation. ERα status clinical importance, as ERα-positive can be successfully treated adjuvant therapy with antiestrogens or aromatase inhibitors. Complications arise from frequent development drug resistance that might caused multiple alterations, including components signaling, during tumor metastasis....
Gallbladder cancer (GBC) is a leading cause of cancer-related deaths worldwide, and its prognosis remains poor, with 5-year survival rate ~5%. Given the crucial role microRNAs (miRNAs) in metastasis, we aimed to analyze expression function metastasis-associated miRNA miR-29c-5p GBC.We validated that was significantly downregulated GBC closely associated lymph node overall disease-free 40 patients who were followed clinically. Ectopic overexpression dramatically repressed proliferation,...
There is increasing evidence that liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) initiation and progression. MicroRNA (miRNA) plays a significant functional role by directly regulating respective targets in LCSCs-triggered HCC, however, little known about the function of miRNA-302 family LCSCs.MiRNAs microarray was used detect miRNAs involved LCSCs maintenance differentiation. Biological roles molecular mechanism miRNA-302a/d its target gene E2F7 were detected...
Due to its potential adverse effects on human health, perfluorooctanoic acid (PFOA), one of the once widely used legacy per- and polyfluoroalkyl substances (PFASs), has been recently replaced by novel alternatives including hexafluoropropylene-oxide-dimer-acid (GenX) ammonium 4,8-dioxa-3H-perfluorononanoate (ADONA). These alternative PFASs are detected in water exposed workers. can enter organs like thyroids, however, it is yet unknown whether new safer than PFOA. In current study, we...
Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated the regulation of cell proliferation, invasive migration and survival. However, PHB expression its biological function gallbladder cancer (GBC) remain largely unknown. p-ERK expressions were determined human GBC tissues by immunohistochemistry (IHC). The effects knockdown on proliferation invasiveness evaluated using Cell Counting Kit-8 (CCK-8) viability, cycle analysis, transwell invasion...
Estrogen receptor alpha (ER alpha) is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. ER positive can be well controlled by modulators, such as tamoxifen. However, tamoxifen resistance commonly observed altered signaling. Thus, further understanding molecular mechanisms, which regulates signaling, important to improve therapy. SMURF1 protein expression levels were measured western blot, while target genes real-time PCR. WST-1 assay was used...
// Yichun Qiao 1 , Chiou-Nan Shiue 2, 3 Jian Zhu Ting Zhuang Philip Jonsson 4 Anthony P.H. Wright 2 Chunyan Zhao Karin Dahlman-Wright 1, 5 Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden Clinical Research Center (KFC), Laboratory Medicine, Pediatrics, Hualien Tzu Chi Hospital, Buddist Medical Foundation, Hualien, Taiwan for Nuclear Receptors Cell Signaling, Biology Biochemistry, University Houston, USA Science Life Laboratory, Solna, Correspondence to:...
Abstract Breast cancer is the most common malignancy for women worldwide, while Triple Negative Cancer (TNBC) accounts 20% in all patients. Compared with estrogen receptor positive breast cancer, which could be effectively controlled via endocrine therapy, TNBC more aggressive and worse prognosis. It therefore urgent necessary to develop a novel therapeutic strategy treatment. Recent studies identified Hippo signaling highly activated TNBC, driving pathway progression. In our study, we...
Abstract Background Disturbances in sleep have been associated with systemic inflammation and increased susceptibility to various chronic diseases. However, the specific mechanisms by which influences plasma protein expression contributes risk of inflammatory bowel disease (IBD) not fully elucidated. Methods We analysed data from 381,228 participants UK Biobank. Sleep was scored chronotype, duration, insomnia, daytime sleepiness. Adjusted odds ratios (ORs) for prevalent IBD unhealthy...
Chronic kidney disease (CKD)-induced osteoporosis is a new concept that implies CKD-related impaired bone quality. Resveratrol (RES) natural component, known for its anti-inflammatory and anti-osteoporotic effects. In the present study, we aimed to investigate bone-protective effects of resveratrol in rats with chronic disease-induced osteoporosis. The 5/6th nephrectomy (Nx) model CKD was established. alendronate (ALN), as standard drug, were administered 45 days. Blood samples femurs...
Magnolol, the major active compound found in Magnolia officinalis has a wide range of clinical applications due to its anti-inflammation and anti-oxidation effects. This study investigated effects magnolol on growth human gallbladder carcinoma (GBC) cell lines. The results indicated that could significantly inhibit GBC lines dose- time-dependent manner. Magnolol also blocked cycle progression at G0 /G1 phase induced mitochondrial-related apoptosis by upregulating p53 p21 protein levels...
// Ting Zhuang 1, * , Jian Zhu Zhilun Li 1 Julie Lorent 2 Chunyan Zhao Karin Dahlman-Wright 3 Staffan Strömblad Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden Oncology Pathology, Solna, Science for Life Laboratory (SciLifeLab), These authors have contributed equally to this work Correspondence to: Strömblad, e-mail: staffan.stromblad@ki.se Keywords: PAK4, ERα, tamoxifen resistance, phosphorylation, small molecule inhibitor Received: July 07, 2015...
EGFR mutation is a strong predictor of efficacy epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) therapy in advanced non-small cell lung cancer (NSCLC). However, around 20–30 % EGFR-mutated cases showed no response to EGFR-TKIs, suggesting that other determinants beyond likely exist. This study analyzed the role microRNAs (miRNAs) primary resistance EGFR-TKIs NSCLC patients with mutation. Training group: 20 19 deletion treated first-line were enrolled; half them had...
Increasing evidence supports that microRNA (miRNA) plays a significant functional role in cancer progression by directly regulating respective targets. In this study, the expression levels of miR-105-1 and its target gene were analyzed using genes microarray hierarchical clustering analysis followed validation with quantitative RT-PCR hepatocellular carcinoma (HCC) normal liver tissues. We examined nuclear receptor coactivator 1 (NCOA1), potential miR-105-1, following transfection mimics or...
The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis commonly observed gastric cancer, while effective therapeutic targets for are lacking. Identification reliable drug underlying mechanisms that could inhibit activity cancer progression urgently needed.We used several cell lines xenograft models performed immunoblotting, qPCR, vivo studies to investigate function CXCR7 progression.In our current study, we demonstrate membrane receptor...