A5002894637- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Kruppel-like factors research
- Ion Channels and Receptors
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Yersinia bacterium, plague, ectoparasites research
- Inflammatory Biomarkers in Disease Prognosis
- Wnt/β-catenin signaling in development and cancer
- Sleep and related disorders
- Forensic and Genetic Research
- Sleep and Work-Related Fatigue
- Ion Transport and Channel Regulation
- Health disparities and outcomes
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Chronic Myeloid Leukemia Treatments
State Key Laboratory of Cardiovascular Disease
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2024
Penn State Milton S. Hershey Medical Center
2011-2024
National Clinical Research
2023
Fu Wai Hospital
2017-2022
Peking Union Medical College Hospital
2017-2022
University of California Davis Medical Center
2018-2019
Zero to Three
2018
Temple University
2016
Shanxi Medical University
2013-2015
Diabetes is a risk factor for the development of acute kidney injury (AKI) in humans and rodents. However, mechanistic basis this observation unknown. The present studies evaluated role inflammation TNF-α ischemic AKI model type 2 diabetes mellitus (DM). Diabetic ( db/ db) nondiabetic db/+) littermates were subjected to 20 min bilateral renal ischemia. mice developed only mild transient dysfunction. In contrast, equivalent insult provoked severe sustained dysfunction db mice. expression...
Timothy syndrome (TS) is a multiorgan dysfunction caused by Gly to Arg substitution at position 406 (G406R) of the human CaV1.2 (L-type) channel. The TS phenotype includes severe arrhythmias that are thought be triggered impaired open-state voltage-dependent inactivation (OSvdI). effect mutation on other L-channel gating mechanisms has yet investigated. We compared kinetic properties exogenously expressed (HEK293 cells) rabbit cardiac L-channels with (G436R; corresponding in clone) and...
Sensitization of esophageal sensory afferents by inflammatory mediators plays an important role in nociception. We have shown mast cell activation induces long-lasting mechanical hypersensitivity vagal nodose C-fibers. However, the roles and downstream ion channels this process are unclear. Mast tryptase via protease-activated receptor 2 (PAR2)-mediated pathways sensitizes nerves hyperalgesia. Transient potential A1 (TRPA1) mechanosensory transduction Here we tested hypothesis that a...
Magnolol, the major active compound found in Magnolia officinalis has a wide range of clinical applications due to its anti-inflammation and anti-oxidation effects. This study investigated effects magnolol on growth human gallbladder carcinoma (GBC) cell lines. The results indicated that could significantly inhibit GBC lines dose- time-dependent manner. Magnolol also blocked cycle progression at G0 /G1 phase induced mitochondrial-related apoptosis by upregulating p53 p21 protein levels...
The present study was undertaken to test the hypothesis that gene delivery of BCL2-Associated Athanogene 3 (BAG3) heart mice with left ventricular dysfunction secondary a myocardial infarction could enhance cardiac performance.BAG3 is 575 amino acid protein has pleotropic functions in cell including pro-autophagy and anti-apoptosis. Mutations BAG3 have been associated both skeletal muscle familial dilated cardiomyopathy levels are diminished non-familial failure.Eight-week-old C57/BL6...
Abstract Esophageal cancer is a leading cause of death, especially in developing countries. In high‐risk regions, squamous cell carcinoma the most common type esophageal cancer, and its etiology remains poorly understood. The purpose this study was to evaluate association between human papillomavirus (HPV) infection (ESCC) related precursor lesions area China. We conducted cross‐sectional among adult inhabitants Linxian, All subjects were interviewed about potential risk factors, had length...
Coronary bifurcation lesion, as a complex coronary is associated with higher risk of long-term poor prognosis than non-bifurcation lesions. The triglyceride-glucose (TyG) index has been shown to predict cardiovascular (CV) events in patients artery disease (CAD). However, the prognostic value TyG lesions who are at high CV remains undetermined. Therefore, this study aimed investigate association between and lesions.A total 4530 consecutive angiography-proven CAD were included from January...
The phosphorylated, activated cytoplasmic domains of the transforming growth factor-beta (TGFbeta) receptors were used as probes to screen an expression library that was prepared from a highly TGFbeta-responsive intestinal epithelial cell line. One TGFbeta receptor-interacting proteins isolated identified be mammalian homologue LC7 family (mLC7) dynein light chains (DLCs). This 11-kDa protein interacts with receptor complex intracellularly and is phosphorylated on serine residues after...
Abstract We have previously reported that the dynein light chain (DLC) km23‐1 is required for Smad2‐dependent TGFβ signaling. Here we describe another member of km23/DYNLRB/LC7/robl family DLCs, termed km23‐2, which also involved in show not only stimulates interaction km23‐2 (DYNLRB2) with receptor II (TβRII) but regulates between and endogenous TβRII vivo. In addition, treatment causes phosphorylation, whereas a kinase‐deficient form prevents phosphorylation. contrast to isoform, blockade...
Abstract Mutations and single nucleotide polymorphisms of AT-rich interactive domain-containing protein 5B (ARID5B) are involved in the oncogenesis acute lymphoblastic leukemia (ALL) treatment outcomes. However, ARID5B expression clinical significance ALL remain unclear. We found is significantly down-regulated compared to healthy bone marrow controls. also interacts with PHD finger 2 (PHF2). Low ( low ) or PHF2 correlated markers cell proliferation poor prognosis patients. Ikaros directly...
Jailed balloon technique (JBT) is an active side branch (SB) protection strategy and considered to be superior the jailed wire (JWT) in reducing SB occlusion. However, no randomized trials have proved that. We aim investigate whether JBT could decrease occlusion rate.Conventional versus Intentional straTegy patients with high Risk prEdiction of Side OccLusion coronary bifurcation interVEntion (CIT-RESOLVE) (NCT02644434, registered on December 31, 2015) (https://clinicaltrials.gov) a trial...
Risk stratification of patients with acute myocardial infarction (AMI) is clinical significance. Although there are many existing risk scores, periodic update required to reflect contemporary patient profile and management. The present study aims develop a model predict in-hospital death among AMI as soon possible after admission. We included 23417 from China Acute Myocardial Infarction (CAMI) registry January 2013 September 2014 extracted relevant data. Patients were divided chronologically...
We have found that phospholemman (PLM) associates with and modulates the gating of cardiac L-type calcium channels (Wang et al., Biophys J 98: 1149–1159, 2010). The short 17 amino acid extracellular NH 2 -terminal domain PLM contains a highly conserved PFTYD sequence defines it as member FXYD family ion transport regulators. Although we learned great deal about PLM-dependent changes in channel gating, little is known regarding molecular mechanisms underlying observed changes. Therefore,...
Sensitization of esophageal nociceptive afferents by inflammatory mediators plays an important role in nociception. Our previous studies demonstrated that mast cell activation increases the excitability nodose C-fibers. But intracellular mechanism this sensitization process is still less clear. We hypothesize extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway activation-induced C-fiber neurons. Mast vivo distension-induced phosphorylations ERK1/2 were studied...