A5101511528- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Sexual Differentiation and Disorders
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Autophagy in Disease and Therapy
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- Chemokine receptors and signaling
- Proteoglycans and glycosaminoglycans research
- Vitamin C and Antioxidants Research
- Immune Response and Inflammation
- Pharmacogenetics and Drug Metabolism
- Polyamine Metabolism and Applications
- Diabetes and associated disorders
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
Shanghai First People's Hospital
2010-2020
Nanjing Medical University
2020
Ruijin Hospital
2002-2003
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. It has been demonstrated that micro-RNAs (miRNAs) are involved in development of PTC. The miRNA-chromatin immunoprecipitation microarray assay revealed down-regulation miR-219-5p; however, effect miR-219-5p on PTC cell growth remains unknown. This result implied critical role PTC.We investigated association between and development. Expression was monitored 30 tissue specimens compared with normal specimens. studied by...
In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains be elucidated. this study, we found that receptor LMW-HA, TLR4, was aberrantly overexpressed tissues and cell line W3. Exposure W3 cells promoted proliferation migration via TLR4. Knockdown TLR4 has provided evidence is essential for LMW-HA-induced CXCR7 expression, which responsible cells. tumor-bearing...
The present study aimed to explore the mechanisms of long non‑coding RNA TUG/miR‑204/SIRT1 axis in pathogenesis obesity. For this purpose, a diabetic mouse model was constructed using high‑fat diet and streptozocin, mice were treated with TUG1 virus via tail intravenous injection. Body weight, serum glucose levels, insulin levels testicular fat, as well expression TUG1, miR‑204, Sirtuin 1 (SIRT1) AMP‑activated protein kinase (AMPK)/acetyl‑CoA carboxylase (ACC) signaling pathway detected....
The expressions of endoplasmic retieulum stress markers,including heavy-chain binding protein(Bip),inositol requiting enzymel(IRE1),PKR-like reticulum kinase(PERK),and oxygen-regulated protein(ORP150),were increased in omental adipose tissue obese patients[1.4(1.4)vs0.9(0.6).2.0±0.8 vs 1.3±0.8,2.4(2.9)vs 1.5(1.2),1.6(2.6)vs 0.6(0.5),all P<0.05].PERK and ORP150 were correlated with body mass index.Bip,ORP150,X-box protein(XBP1),and IRE1 the tumor necrosis factor-α interleukin-6.The results...