A5050808163- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Kawasaki Disease and Coronary Complications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebrovascular and Carotid Artery Diseases
- Coronary Artery Anomalies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Aortic aneurysm repair treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Structural Anomalies and Repair
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Advanced MRI Techniques and Applications
- Blood Pressure and Hypertension Studies
- Hydrogen embrittlement and corrosion behaviors in metals
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
National Clinical Research Center for Digestive Diseases
2020-2025
State Key Laboratory of Cardiovascular Disease
2018-2024
Fu Wai Hospital
2010-2024
National Clinical Research
2021-2024
Peking Union Medical College Hospital
2010-2022
Beijing Anzhen Hospital
2013
Capital Medical University
2013
Ministry of Science and Technology of the People's Republic of China
2007
Wuhan University
2007
Abstract Background The role of triglyceride-glucose (TyG) index, an insulin resistance indicator, in glycemic management for diabetic patients with coronary artery disease (CAD) was still unknown. Therefore, we aimed to explore the association between control and cardiovascular (CV) outcomes diabetes CAD according different TyG index levels. Methods A total 9996 angiograph-proven were consecutively recruited from 2017 2018 at Fuwai Hospital. Patients assigned into 3 groups tertiles (T) (T1:...
AimsTo investigate whether Atorvastatin (Ator) treatment improves the cardiac micro-environment that facilitates survival and differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) implanted in post-infarct myocardium.
A novel PDLLA-Zn-FeN BRS biodegrades completely after ~2 years in rabbits and humans, with excellent biocompatibility.
The first-generation polymeric bioresorbable scaffolds resulted in higher than acceptable 3-year rates of device-related adverse outcomes.
Abstract Background Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors. This study sought to evaluate combined impact of RC, Lp(a), on prognosis statin-treated patients with chronic coronary syndrome (CCS), which has not been investigated. Methods A total 6839 CCS were consecutively enrolled. Baseline high-sensitivity C-reactive protein (hsCRP) concentrations measured their medians used for...
This study aims to evaluate the relationship between apolipoproteins (ApoA1, ApoB, and ApoB/A1 ratio) incidence of major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) impaired kidney function, assessing their potential role secondary prevention. A prospective cohort 1,640 function who underwent percutaneous intervention China was analyzed. Patients were categorized based on measurements ApoA1, ratio. MACE, defined as a composite all-cause mortality,...
The FAVOR (Comparison of Quantitative Flow Ratio Guided and Angiography Percutaneous Intervention in Patients with Coronary Artery Disease) III China trial demonstrated that percutaneous coronary intervention (PCI) lesion selection using quantitative flow ratio (QFR) measurement, a novel angiography-based approach for estimating fractional reserve, improved two-year clinical outcomes compared standard angiography guidance. This study aimed to assess the cost-effectiveness QFR-guided PCI from...
Objectives We aimed to investigate the effect of bifurcation angle (BA) on side branch (SB) occlusion after main vessel (MV) stenting. Background : BA is thought impact risk SB in coronary patients undergoing percutaneous intervention (PCI). Methods A total 1,171 consecutive with 1,200 lesions one stent or provisional two techniques were studied. The divided into low and high groups using median (52°). Multivariate logistic regression analysis was performed identify independent predictors...
Coronary bifurcation lesion, as a complex coronary is associated with higher risk of long-term poor prognosis than non-bifurcation lesions. The triglyceride-glucose (TyG) index has been shown to predict cardiovascular (CV) events in patients artery disease (CAD). However, the prognostic value TyG lesions who are at high CV remains undetermined. Therefore, this study aimed investigate association between and lesions.A total 4530 consecutive angiography-proven CAD were included from January...
Background Successful revascularization of coronary artery disease, especially ST-elevation myocardial infarction (STEMI), does not always mean optimal reperfusion in a portion patients because no-reflow phenomenon. We hypothesized that statins might attenuate the incidence when used before percutaneous intervention (PCI). The purpose this study was to summarize evidence pre-procedural statin therapy reduce after PCI. Methods searched MEDLINE, Cochrane, and clinicaltrials.gov databases from...
The relationship between remnant cholesterol (RC) and atherosclerotic cardiovascular risk has been given increasing attention in recent years. However, its association with verbal learning memory performance not reported.Data were extracted from the National Health Nutrition Examination Survey (NHANES) 2011-2014 database. Participants aged ≥60 years available fasting lipid data included. Verbal evaluated using Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Task...
The quantitative flow ratio (QFR) identifies functionally ischaemic lesions that may benefit more from percutaneous coronary intervention (PCI) than medical therapy.
Background Our previous studies have demonstrated that Tongxinluo (TXL), a traditional Chinese medicine, can protect hearts against no-reflow and reperfusion injury in protein kinase A (PKA)-dependent manner. The present study was to investigate whether the PKA-mediated cardioprotection of TXL relates inhibition myocardial inflammation, edema, apoptosis. Methods In 90-minute ischemia 3-hour model, minipigs were randomly assigned sham, control, (0.05 g/kg, gavaged one hour prior ischemia), +...
This study aimed to explore whether 99mTc-radiolabeled fibroblast activation protein inhibitor (99mTc-HFAPi) imaging can detect early myocardial fibrosis in the hypertensive heart.In experimental model, spontaneously rats (SHRs) and age-matched Wistar Kyoto (WKYs) were randomly divided into three groups (8, 16, 28 weeks). The animals underwent 99mTc-HFAPi echocardiography. Autoradiography histological analyses performed left ventricle. mRNA expression level of (FAP) collagen I measured using...
Doxorubicin (DOX) is an effective anticancer drug which widely used in clinical treatment. However, the severe cardiotoxicity limits its use. Thus, it urgent need to attenuate toxicity of DOX without impairing efficacy. Many studies show that Se may protect normal tissues from damages some drugs. Recently, Se@SiO2 nanocomposites emerges as better substitutes for direct element treatment cancer cells their ideal biocompatibility. In present article, we synthesized and confirmed...