Background: Delay or failure of bone union is a significant clinical challenge all over the world, and it has been reported that marrow mesenchymal stem cells (BMSCs) offer promising approach to accelerate fracture healing. Se can modulate proliferation differentiation BMSCs. Se-treatment enhances osteoblastic BMSCs inhibiting formation mature osteoclasts. The purpose this study was assess effects porous [email protected] 2 nanocomposite on regeneration underlying biological mechanisms....

Objectives: This study is aimed at assessing glymphatic function by diffusion tensor image analysis along the perivascular space (DTI-ALPS) and its associations with cortical morphological changes severity of accommodative asthenopia (AA). Methods: We prospectively enrolled 50 patients AA 47 healthy controls (HCs). All participants underwent imaging (DTI) T1-weighted completed survey scale (ASS). Differences in brain morphometry (ALPS) index between two groups were compared. The correlation...

Reducing oxidative stress (ROS) have been demonstrated effective for steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH). Selenium (Se) plays an important role in suppressing and has huge potential ONFH treatments. However Se a narrow margin between beneficial toxic effects which make it hard therapy use vivo. In order to deficiency up, control release (Se@SiO2) were realized by nanotechnology modification. Porous Se@SiO2 nanocomposites favorable biocompatibility can...

Methylprednisolone (MPS) is an important drug used in therapy of many diseases. However, osteonecrosis the femoral head a serious damage MPS treatment. Thus, it imperative to develop new drugs prevent side effect MPS.The potential interferences Se@SiO2 nanocomposites may have therapeutic methylprednisolone were evaluated by classical index acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1β and TNF-α. And oxidative stress species (ROS) like...

Doxorubicin (DOX) is an effective anticancer drug which widely used in clinical treatment. However, the severe cardiotoxicity limits its use. Thus, it urgent need to attenuate toxicity of DOX without impairing efficacy. Many studies show that Se may protect normal tissues from damages some drugs. Recently, Se@SiO2 nanocomposites emerges as better substitutes for direct element treatment cancer cells their ideal biocompatibility. In present article, we synthesized and confirmed...

We explored the dynamic alterations of intrinsic brain activity and effective connectivity after acupuncture treatment to investigate underlying neurological mechanism in patients with migraine without aura (MwoA). The Functional Magnetic Resonance Imaging (fMRI) scans were separately obtained at baseline, first 12th sessions 40 MwoA. Compared healthy controls (HCs), MwoA mostly showed a decreased amplitude low-frequency fluctuation (dALFF) variability rostral ventromedial medulla (RVM),...

Abstract: The metastasis of cancer cells is a vital aspect disease progression and therapy. Although few nanoparticles (NPs) aimed at controlling in therapy have been reported, the NPs are normally combined with drugs, yet direct therapeutic effects not reported. To study influence on metastasis, potential suppression capacity [email protected] 2 -PEG to tumor cell migration, kind typical photothermal NPs, was systemically evaluated this study. Using NP stimulation trans­well migration...

Background: Spinal manipulative therapy (SMT) helps to reduce pain of patients with chronic low back (cLBP). However, the underlying mechanism SMT for relief and brain response treatment remains unclear. We utilized functional magnetic resonance imaging (fMRI) assess effect spinal on (cLBP) in real-time mechanical stimulus. Methods: Patients cLBP (group1, 14 participants) age-matched healthy participants (group2, 20 were prospectively enrolled. FMRI was performed group1 at three time-points:...

Drug delivery system studies aim to improve nanoparticle (NP) formulation enable efficient of NPs tumors. However, must be transported by blood or through direct injection. How leave the circulatory and how diffuse into a tumor remain unclear, this uncertainty is limitation drug systems. The intimate connection between these questions metabolism may related their biosafety in vivo. Thus, study, classical carrier SiO2 were used as typical transport NPs, fluorescein isothiocyanate (FITC) was...

The aim of this study was to explore simultaneous brain network responses electroacupuncture stimulation (EAS) at scalp acupoints by accounting for placebo effects.Sixty healthy subjects were recruited and randomly divided into two groups: Group 1 2. Functional magnetic resonance imaging (fMRI) performed in with sham acupuncture Shenting (GV24) Touwei (ST8) without EAS. 2 underwent verum EAS the same during fMRI. Independent component analysis used analyze fMRI data. Full-factor statistical...

To explore the central processing mechanism of pain perception in chronic low back (cLBP) using multi-voxel pattern analysis (MVPA) based on static and dynamic fractional amplitude low-frequency fluctuations (fALFF) analysis, spectral causal modeling (spDCM). Thirty-two patients with cLBP 29 matched healthy controls (HCs) for first cohort 24 22 HCs validation underwent resting-state fMRI scan. The alterations fALFF were as classification features to distinguish from HCs. brain regions gotten...

To investigate the effect of electroacupuncture (EA) on cognitive dysfunction in rats with hepatic encephalopathy and its underlying mechanism.Fifty Wistar were randomly divided into a normal group (n = 10) model 40). Rat models established by administration carbon tetrachloride thioacetamide for total 12 weeks. At 9th week after modeling, impairment identified conducting Morris water maze test, which then control (CCl4) treatment groups including EA (CCl4 + EA), lactulose Lac), plus CM), 9...

<title>Abstract</title> Background Chronic obstructive pulmonary disease (COPD) is a prevalent condition characterized by significant morbidity and mortality. It ranks as the primary cause of adult mortality globally, entailing substantial economic costs. Numerous studies indicate linkage between serum copper(Cu), copper-selenium ratio(Cu/Se-ratio), diverse diseases. However, relationships Cu, Cu/Se-ratio, COPD among smokers non-smokers has been understudied, warranting additional...

BackgroundAlterations in the static and dynamic characteristics of spontaneous brain activity have been extensively studied to investigate functional changes migraine without aura (MwoA). However, alterations concordance among dynamics MwoA remain largely unknown. This study aimed determine possibilities diagnosis based on indices.MethodsResting-state MRI scans were performed 32 patients with 33 matched healthy controls (HCs) first cohort, as well 36 HCs validation cohort. The indices...

Great efforts recently have advanced the investigation of high-mobility two-dimensional semiconductor Bi2O2Se toward its device applications, which arouses more questions to clarify intriguing charge behaviors Bi2O2Se. The present work introduced Sm atoms partially substitute Bi for modulating properties supposed conduction Bi2O2 layer. A behavior with double transport channels was then discovered, one significantly suppressed by doping, but another exempt. Such a selective suppression in...

To compare the performance of a 12-channel flexible head coil (HFC12) with commercial 16-channel (HRC16) and 24-channel (HRC24) rigid coils.The phantom study was performed on 1.5 T MR scanner HFC12, HRC16, HRC24. The SNR noise correlation matrix T1WI, T2WI, diffusion weighted imaging (DWI) were measured. profiles created according to SNR. In addition, 1/g-factors calculated in different acceleration directions. vivo study, DWI one healthy volunteer three coils. measured.In HFC12 transverse,...

Objective : To investigate the innovative application of gold nanorods combined with a laser in posttraumatic osteoarthritis (PTOA) modeling and to discuss possible mechanisms. Methods Electron microscopy was used characterize nanorods. Cell counting kit-8 assay enzyme-linked immunosorbent were evaluate cell proliferation cytotoxicity. An infrared spectroscopy (IR) thermal camera monitor temperature changes or without treatment. Furthermore, western blotting expression related proteins...

Objective To contrast the effect between laparoscopic repair and open surgery for curing ventral incisional hernia (VIH). Methods From August 2011 to January 2014, fifty-two patients with VIH undergoing surgical treatment were absorbed as research object, including 28 cases of group 24 group. Operation time, intra-operative blood loss, hospital stay, site infection postoperative pain in two groups observed. Results Operations both successful. Compared group, showed significant...

Abstract We explored the dynamic alterations of intrinsic brain activity and effective connectivity after acupuncture treatment to investigate underlying neurological mechanism in patients with migraine without aura (MwoA). The fMRI scans were separately obtained at baseline, first 12th sessions 40 MwoA. Compared HCs, MwoA showed mostly decreased amplitude low-frequency fluctuation (dALFF) variability regions differences. After treatment, dALFF rostral ventromedial medulla (RVM), superior...

Abstract Objective: Based on different post-processing methods and amplitude frequencies of fMRI, this study aimed to compare the ability flexible rigid coils for evaluating changes in spontaneous brain activity after electroacupuncture at Zusanli (ST36). Methods: A total 28 healthy subjects who underwent intervention using 12-channel head 16-channel were enrolled. BOLD-fMRI examination was conducted before immediately acupuncture. The fractional low-frequency fluctuations (fALFF), percent...

Abstract Background: The underlying neurological mechanism of acupuncture treatment in migraine without aura (MwoA) remains unclear. Therefore, we explored the dynamic alterations intrinsic brain activity and effective connectivity patients with MwoA after treatment. Methods: fMRI scans were separately obtained at baseline, first 12th sessions 40 MwoA. treatments finished within 6 weeks as twice a week. 36 matched healthy controls (HCs) recruited performed once scan. amplitude low-frequency...