A5100334148- Functional Brain Connectivity Studies
- Cancer-related molecular mechanisms research
- Mental Health Research Topics
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Advanced Neuroimaging Techniques and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Neurodegenerative Diseases
- Acute Myeloid Leukemia Research
- Winter Sports Injuries and Performance
- Remote Sensing and LiDAR Applications
- Bladder and Urothelial Cancer Treatments
- Kruppel-like factors research
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Natural Compounds
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Tryptophan and brain disorders
- Higher Education Learning Practices
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Natural Language Processing Techniques
Southern Medical University
2017-2023
Nanfang Hospital
1998-2023
Hebei Agricultural University
2023
Fuzhou General Hospital of Nanjing Military Command
2023
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Wuhan University
2023
Zhongnan Hospital of Wuhan University
2023
Shuguang Hospital
2023
Shanghai University of Traditional Chinese Medicine
2023
Acute lung injury (ALI) is a common complication of heat stroke (HS) and direct cause death. However, the mechanism underlying ALI following HS remains unclear.To investigate whether ferroptosis involved in HS-ALI. We established model mice mouse epithelial-2 cells (MLE-2). The severity was measured by H&E staining, wet-to-dry weight ratio, Transmission electron microscopy. Potential markers Fe2+, malondialdehyde (MDA), hydroxynonenal (4-HNE) lipid peroxidation were detected. percentages...
Stroke may lead to widespread functional and structural reorganization in the brain. Several studies have reported a potential correlation between network changes after stroke. However, it is unclear how functional-structural relationships change dynamically over course of one resting-state fMRI scan patients following stroke; furthermore, we know little about their with severity motor dysfunction. Therefore, this study aimed investigate dynamic connectivity (FC-SC) coupling its relationship...
Abstract The molecular mechanism for nobiletin’s protective effect against heatstroke-induced acute lung injury (HS-ALI) remains largely unknown. Previous research has demonstrated that ferroptosis is an important pathogenic event in HS-ALI. Nobiletin a natural polymethoxylated flavonoid. Herein, we investigated the potential contribution of nobiletin to HS-ALI by inhibiting ferroptosis. Heat stress was used induce mice, and MLE-12 cells were stimulated heat vitro . administrated gavage 2...
Background Patients in minimally conscious state (MCS) exist measurable evidence of consciousness. The frontal lobe is a crucial part the brain that encodes abstract information and closely related to state. We hypothesized disturbance functional network exists MCS patients. Methods collected resting-state near-infrared spectroscopy (fNIRS) data fifteen patients sixteen age- gender-matched healthy controls (HC). Coma Recovery Scale-Revised (CRS-R) scale was also composed. topology analyzed...
Background: A hallmark of atherosclerosis is the formation macrophage-derived foam cells.Serum amyloid P component (SAP), a member pentraxin family proteins, known to affect macrophage activation.However, role SAP in still unclear.Methods: Apolipoprotein E-deficient (Apoe -/-) mice fed high-fat diet were given intraperitoneal injections (6 mg/kg) every other day for total 2 weeks characterize development. Results:We showed that injection attenuated Apoe -/- mice.Immunostaining aortic roots...
Abstract Mounting evidence has demonstrated the considerable regulatory effects of long noncoding RNAs (lncRNAs) in tumorigenesis and progression various carcinomas. LncRNA Semaphorin 3B (SEMA3B) antisense RNA 1 ( SEMA3B‐AS1 ) been found to be dysregulated a few carcinomas recently. However, its potential function mechanism colorectal carcinoma (CRC) have not yet examined. Here we show that acts as crucial regulator CRC progression. We expression was downregulated cell lines tissues....
Necroptosis, a form of regulated necrosis, has been reported to be involved in numerous pathologies, including sepsis. However, protective effect the selective inhibitor necroptosis, necrostatin-1 (Nec-1), against sepsis remains confirmed. Animals (rats and mice) were subjected cecal ligation puncture (CLP) mimic clinical Nec-1 or its vehicle (control) was administered 20 min before CLP. Survival time observed up 72 h after Specimens liver tissue serum obtained at 6 h, 12 18 h. Expression...
Bladder cancer (BCa) is a commonly diagnosed malignancy worldwide that has poor survival depending on its intrinsic biologic aggressiveness and peculiar radio- chemoresistance features. Gaining better understanding of tumorigenesis developing new diagnosis treatment strategies for BCa important improving clinical outcome. SLC25 family member 21 (SLC25A21), carrier transporting C5-C7 oxodicarboxylates, been reported to contribute oxoadipate acidemia. However, the potential role SLC25A21 in...
Spinocerebellar ataxia type 3 (SCA3) is a rare movement disorder characterized with ataxia. Previous studies on disorders show that the whole-brain functional network tends to be more regular, and these reconfigurations correlate genetic clinical variables.To test whether brain in patients SCA3 follows similar reconfiguration course other disorders, we recruited 41 (mean age = 40.51 ± 12.13 years; 23 male) sex-matched healthy individuals (age 40.10 11.56 24 male). In both groups, topology of...
Cerebral ischemia and the subsequent cerebral ischemia-reperfusion (I/R) injury usually result in neuronal impairment with serious disabilities. Although neural stem cell (NSC) transplantation can help functional recovery after stroke, due to improper cellular milieu brain injury, direct NSC will low survival rates differentiation efficiency into neurons. Here a conductive hybrid hydrogel based on gelatin methacryloyl (GelMA) poly(3,4-ethylenedioxythiophene): poly (styrene sulfonate)...
Abstract Background We hypothesize that the tumor necrosis factor-α (TNF-α) may play a role in disturbing effect of selective serotonin reuptake inhibitor (SSRI) on striatal connectivity patients with major depressive disorder (MDD). Methods performed longitudinal observation by combining resting-state functional magnetic resonance imaging (rs-fMRI) and biochemical analyses to identify abnormal MDD patients, evaluate TNF-α level these connectivities during SSRI treatment. Eighty-five rs-fMRI...
Animal welfare concerns in laying-hen production facilities have necessitated research on alternative strategies for improving egg and hen health. At present, most China use the fasting method, but with international emphasis animal welfare, scholars begun to find ways improve efficiency while ensuring standards are adhered to. Therefore, this study investigated effects of non-fasting molting performance, oxidative stress, intestinal morphology, liver health laying hens. A total 180 healthy...
To explore the central processing mechanism of pain perception in chronic low back (cLBP) using multi-voxel pattern analysis (MVPA) based on static and dynamic fractional amplitude low-frequency fluctuations (fALFF) analysis, spectral causal modeling (spDCM). Thirty-two patients with cLBP 29 matched healthy controls (HCs) for first cohort 24 22 HCs validation underwent resting-state fMRI scan. The alterations fALFF were as classification features to distinguish from HCs. brain regions gotten...
Multimodal Large Language Models (MLLMs) have recently demonstrated strong performance across a wide range of vision-language tasks, garnering significant attention in the computer vision. However, their efficient deployment remains substantial challenge due to high computational costs and memory requirements. Recognizing redundancy information within vision modality, recent studies explored methods for compressing visual tokens MLLMs enhance efficiency training-free manner. Despite...
There are various depressive subtypes identified in patients with major disorder (MDD). Depression psychotic symptoms is usually known to be a severe type of depression that includes such as delusions and/or hallucinations, and remains common condition often underrecognized inadequately treated clinical practice. Electroencephalography (EEG) biomarkers have been implicated classify healthy psychopathological neural signals using machine learning algorithms. In this study, we sought identify...
Three microsurgical techniques, i.e., electric cauterized vein patch (ECVP), segment (ECVS), and muscular cavity (ECMC), were employed to produce an ideal animal model of traumatic pseudoaneurysm (TPA). In this paper, 108 cases TPAs produced in rabbit femoral arteries. The successful rates these proved by angiography, autopsy vivo, histological examination, 5.5, 16.7, 88.9%, respectively. rate ECMC, with the merits simple operation, a narrow neck but giant size TPA which rarely ruptured,...
To evaluate the clinical efficacy and adverse reactions of peginterferon-α2b for treatment chronic myeloproliferative neoplasms (MPN).