A5083994606- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- High Altitude and Hypoxia
- Electron Spin Resonance Studies
- Crystal structures of chemical compounds
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and Biological Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Agricultural Practices and Plant Genetics
- Magnetism in coordination complexes
- Phytochemicals and Antioxidant Activities
- Flavonoids in Medical Research
- Eicosanoids and Hypertension Pharmacology
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Sesquiterpenes and Asteraceae Studies
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
TCM-Intigrated Cancer Center of Southern Medical University
2020-2025
Gansu University of Traditional Chinese Medicine
2025
82th Hospital of Pla
2019-2024
117th Hospital of People's Liberation Army
2023
Xi'an Jiaotong University
2022
Chinese People's Liberation Army
2021
Lanzhou Army General Hospital
2011-2018
Southern Medical University
2018
Air Force Medical University
2008-2016
Rhododendron anthopogonoides Maxim, a kind of traditional Tibetan medicine, has been used to remove body heat, detoxification, cough, asthma, stomachic and swelling, eliminate abundant phlegm inflammatory for long time. In the present study, total phenols flavonoid contents as well antioxidative properties crude extract solvent fractions R. were determined using seven antioxidant assays. Additionally, protective effect extracts on hypoxia-induced injury in PC12 cells was also investigated....
Radiotherapy is a non-invasive method that widely applied to treat and alleviate cancers. However, radiation-induced effects in the immune system are associated with several side via an increase oxidative stress inflammatory response. Therefore, it imperative develop effective clinical radiological protection strategies for of normal organs these patients. To explore more radioprotective agents minimal toxicity, mitochondria-targeted nitronyl nitroxide radical triphenylphosphine ion...
Normal tissue and immune organ protection are critical parts of the tumor radiation therapy process. Radiation-induced damage (RIOD) causes several side reactions by increasing oxidative stress inflammatory responses, resulting in unsatisfactory curability therapy. The aim this study was to develop a novel efficient anti irradiation nanoparticle explore its mechanism protecting splenic from mice. Nanoparticles triphenylphosphine cation NIT radicals (NPs-TPP-NIT) were prepared used protect...
4′,5,6,7-tetrahydoxyisoflavone (6-hydroxygenistein, 6-OHG) is a hydroxylated derivative of genistein with excellent antioxidant activity, but whether 6-OHG can protect hypoxia-induced damage unclear. The objective current study was to evaluate the protective effect and underling mechanism against injury via network pharmacology cellular experiments. 6-OHG-related hypoxia injury-related targets were screened by public databases. intersected used for constructing PPI performing GO KEGG...
Rationale: Exogenous supplementation of beneficial intestinal bacteria can alleviate the behavioural symptoms psychiatric disorders, such as autism spectrum disorder (ASD), through gut-brain interactions. However, application bacteria, Lactobacillus reuteri (L. reuteri), for treating ASD is hindered by limited gut colonization. Methods: Utilizing Spirulina platensis (SP) a natural microcarrier safer and more binding approach was employed to bind surface SP produce SP-intestinal bacteria. Due...
To investigate the mechanisms of 6-hydroxygenistein (6-OHG) in treatment high-altitude hypoxia-induced lung injury. The intersection targets 6-OHG and injury were identified using databases, including Swiss Target Prediction, SuperPred, GeneCards, OMIM. STRING database Cytoscape software used to construct a protein interaction network for drugs diseases, with degree values greater than median as key targets. GO KEGG enrichment analyses performed DAVID identify relevant signaling pathways....
Background: Oxidative stress is considered an important mechanism of acute high-altitude brain injury. Imidazole nitronyl nitroxide radicals are a class stable organic radical scavengers that contain single electrons in their molecules. Therefore, order to search for compounds with low toxicity and better effect against injury, the preparation methods PLGA nanoparticles (TPP-C 6 -HPN@PLGA-NPs) loaded synthesized mitochondria targeting imidazole were emphasized investigated. Furthermore, its...
Abstract Oxidative stress has been considered to be closely related spaceflight‐induced bone loss; however, mechanism is elusive and there are no effective countermeasures. Using cultured rat calvarial osteoblasts exposed microgravity simulated by a random positioning machine, this study addressed the hypotheses that microgravity‐induced shortening of primary cilia leads oxidative cilium protection prevents osteogenesis loss. Microgravity was found induce (as represented increased levels...
Abstract Background Norwogonin is a natural flavone with three phenolic hydroxyl groups in skeletal structure and has excellent antioxidant activity. However, the neuroprotective effect of norwogonin remains unclear. Here, we investigated protective capacity against oxidative damage elicited by hypoxia PC12 cells. Methods The cell viability apoptosis were examined MTT assay Annexin V-FITC/PI staining, respectively. Reactive oxygen species (ROS) content was measured using DCFH-DA assay....
Abstract An efficient, safe, and viable process has been developed for large-scale preparation of salidroside, a natural product. The consists two chemical steps, which produce the salidroside on multikilogram scale with 72% overall yield >98% purity. A series novel analogs were prepared according to same method.
Background:Hypoxia-induced oxidant stress and cardiomyocyte apoptosis are considered essential processes in the progression of heart failure.Tempol is a nitroxide compound that scavenges many reactive oxygen species (ROS) has antioxidant cardioprotective effects.This study aimed to investigate protective effect Tempol against hypoxia-induced oxidative H9c2 rat cardiomyoblast cell line, addition related mechanisms. Material/Methods:H9c2 cells were pre-treated with Tempol, followed by hypoxia...
Acute mountain sickness is caused by sub-acute hypoxia in healthy individuals going rapidly to altitude. Both tissue vitro and whole-body vivo have been found promote the release of reactive oxygen species. Nitronyl nitroxide can trap free radicals such as ·NO or ·OH, may therefore be efficient protective agents. This study assessed ability nitronyl against acute a radical scavenger high-altitude mice model. Normobaric hypobaric model were used estimate protect effects sickness. Low pressure...
Abstract Background We hypothesize that the tumor necrosis factor-α (TNF-α) may play a role in disturbing effect of selective serotonin reuptake inhibitor (SSRI) on striatal connectivity patients with major depressive disorder (MDD). Methods performed longitudinal observation by combining resting-state functional magnetic resonance imaging (rs-fMRI) and biochemical analyses to identify abnormal MDD patients, evaluate TNF-α level these connectivities during SSRI treatment. Eighty-five rs-fMRI...
Three new flavonoid glycosides, kaempferol-3-O-β-D-apiofuranosyl(1 → 2)-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside (1), kaempferol-4'-O-β-D-apiofuranosyl-3-O-β-D-glucopyranosyl-7-O-α-l-rhamnopyranoside (2), and 5,6,7,4'-tetrahydroxy-flavone-6-O-β-D-arabinopyranosyl-7-O-α-L-rhamnopyranoside (3), were isolated from the aerial parts of Urena lobata L., along with 10 known compounds (4-13). Their structures determined based on spectroscopic methods including 1D 2D NMR spectroscopy as well HR-ESI-MS.
Two new compounds 1 and 2 have been isolated from the aerial parts of Urena lobata L. The structures two were established as ceplignan-4-O-β-d-glucoside (1) 2,5-dihydroxy benzoic acid-7-(2,6-dimethyl-6-hydroxy-2,7-octadienoic acid) anhydride-5-O-β-d-apiofuranosyl(1 → 2)-β-d-glucoside (urenoside A) (2), on basis chemical spectral evidence, including 1D 2D NMR spectroscopic data well mass spectrometry (HR-ESI-MS).
To study the chemical constituents of Abelmoschus esculentus.The were isolated and purified by chromatography on silica gel recrystallization. The structures elucidated basis physicochemical properties spectral data.Fourteen compounds identified as 6-hydroxy-stigmasta-4-en-3-one(1), 6-hydroxy-stigmasta4,22-dien-3-one(2), stigmasta-5-en-3-ol-7-one(3), stigmasta-5, 22-dien-3-ol-7-one(4), stigmast-5-en-3, 7-diol(5), stigmast-5, 22-dien-3, 7-diol(6), stigmast-4, 6-dione(7), stigmasta-4,...