A5100328777- Electron Spin Resonance Studies
- Metabolomics and Mass Spectrometry Studies
- Nitric Oxide and Endothelin Effects
- Magnetism in coordination complexes
- High Altitude and Hypoxia
- Lanthanide and Transition Metal Complexes
- Free Radicals and Antioxidants
- Heme Oxygenase-1 and Carbon Monoxide
- Molecular Sensors and Ion Detection
- Neuroscience of respiration and sleep
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Plant-based Medicinal Research
- Biochemical effects in animals
- Crystal structures of chemical compounds
- Redox biology and oxidative stress
- Chemical Synthesis and Analysis
- Biosimilars and Bioanalytical Methods
- Viral Infections and Immunology Research
- Protein Interaction Studies and Fluorescence Analysis
- Cholinesterase and Neurodegenerative Diseases
- Traditional and Medicinal Uses of Annonaceae
- Bladder and Urothelial Cancer Treatments
- Axial and Atropisomeric Chirality Synthesis
Yuhuangding Hospital
2025
Air Force Medical University
2013-2024
Air Force Engineering University
2024
Beijing Normal University
2017
Nanjing University
2006
Shanghai Liangyou (China)
2006
Abstract To address the shortcomings of cystoscopy and urine cytology for detecting grading bladder cancer (BC), ultrahigh performance liquid chromatography (UHPLC) coupled with Q-TOF mass spectrometry in conjunction univariate multivariate statistical analyses was employed as an alternative method diagnosis BC. A series differential serum metabolites were further identified low-grade(LG) high-grade(HG) BC patients, suggesting metabolic dysfunction malignant proliferation, immune escape,...
Radiotherapy is a non-invasive method that widely applied to treat and alleviate cancers. However, radiation-induced effects in the immune system are associated with several side via an increase oxidative stress inflammatory response. Therefore, it imperative develop effective clinical radiological protection strategies for of normal organs these patients. To explore more radioprotective agents minimal toxicity, mitochondria-targeted nitronyl nitroxide radical triphenylphosphine ion...
Normal tissue and immune organ protection are critical parts of the tumor radiation therapy process. Radiation-induced damage (RIOD) causes several side reactions by increasing oxidative stress inflammatory responses, resulting in unsatisfactory curability therapy. The aim this study was to develop a novel efficient anti irradiation nanoparticle explore its mechanism protecting splenic from mice. Nanoparticles triphenylphosphine cation NIT radicals (NPs-TPP-NIT) were prepared used protect...
Abstract Objective To investigate the distribution of health literacy (HL) levels and association HL with proactive personality in patients permanent colostomy. Methods A cross-sectional study was conducted to measure using validated scales. total 172 colostomy were selected from January 2021 May 2022 Yantai City, China. Descriptive statistics, t -test, ANOVA, Pearson correlation analysis, multiple linear regression analysis techniques used. Results The results obtained showed that status...
Background: Oxidative stress is considered an important mechanism of acute high-altitude brain injury. Imidazole nitronyl nitroxide radicals are a class stable organic radical scavengers that contain single electrons in their molecules. Therefore, order to search for compounds with low toxicity and better effect against injury, the preparation methods PLGA nanoparticles (TPP-C 6 -HPN@PLGA-NPs) loaded synthesized mitochondria targeting imidazole were emphasized investigated. Furthermore, its...
An easily tunable protocol for desulfonylative allylation and diacrylation using aldehydes/alkanes allylic sulfones catalyzed by TBADT is reported.
Evidence has accumulated that reactive oxygen species and inflammation play crucial roles in the development of chronic pain, including radicular low back pain. Nonsteroid anti-inflammatory drugs (NSAIDs), for example, salicylic acid, aspirin, provided analgesic effects various types However, long-term use these causes unwanted side effects, which limits their implication. Stable nitronyl (NIT) nitroxide radicals have been extensively studied as a unique interesting class new antioxidants...
Abstract Monoester‐diterpenoid alkaloids are the main bioactive components of Sini decoction, which is a well‐known traditional Chinese medicine formula for treatment myocardial infarction (MI) and heart failure in China. In this work, an ultra‐high‐performance liquid chromatography–mass spectrometry combined with microdialysis method was successfully established applied investigating first time comparative plasma pharmacokinetics three monoester‐diterpenoid (benzoylmesaconitine,...
To search for more effective radiation protectors with minimal toxicity, a water-soluble nitroxides Acetamido-Tempol (AA-Tempol) was evaluated potential radioprotective properties in HUVEC cells (Human Umbilical Vein Endothelial cell line). study the anti-radiation effect of AA-Tempol culture, viability irradiated using clonogenic survival assay examined. The anti-apoptosis effects Annexin V/propidium iodide staining flow cytometry also evaluated. elucidate molecular mechanism against...
Four novel nitroxides were synthesized, and the fluorescence tuning of these molecules with action different chemical inputs was investigated; results suggested that could serve as a redox switch.
In the title nitronyl nitroxide radical compound, C(16)C(23)N(2)O(5), imidazole and benzene rings are twisted with respect to each other, making a dihedral angle of 26.2 (4)°. The ring adopts half-chair conformation. Weak C-H⋯π inter-actions also found.