A5081908047- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Bone health and treatments
- Adenosine and Purinergic Signaling
- Sirtuins and Resveratrol in Medicine
- Listeria monocytogenes in Food Safety
- Immune cells in cancer
- Electrospun Nanofibers in Biomedical Applications
- Radiopharmaceutical Chemistry and Applications
- Mitochondrial Function and Pathology
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Drug Solubulity and Delivery Systems
- Liver Disease Diagnosis and Treatment
- Gas Sensing Nanomaterials and Sensors
- Microbial Inactivation Methods
- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Traditional Chinese Medicine Analysis
- Advanced Drug Delivery Systems
- Pharmacological Effects of Natural Compounds
- Metamaterials and Metasurfaces Applications
Henan Provincial Center for Disease Control and Prevention
2025
Guang’anmen Hospital
2022-2025
China Academy of Chinese Medical Sciences
2025
Air Force Medical University
2015-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021-2024
Xi'an Jiaotong University
2024
Nanjing Agricultural University
2024
Technical Institute of Physics and Chemistry
2021-2024
Chinese Academy of Sciences
2021-2024
University of Chinese Academy of Sciences
2018-2024
Cyclosporin A (CsA) is a promising therapeutic drug for myocardial ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening mitochondrial permeability transition pore (mPTP). However, application cyclosporin treat MI/RI limited due immunosuppressive effect other normal organ and tissues. SS31 represents novel mitochondria-targeted peptide which can guide accumulate into mitochondria. In this paper, nanoparticles (CsA@PLGA-PEG-SS31) were prepared precisely deliver...
The clinic therapeutic effect of resveratrol is limited due to its low oral bioavailability. Piceid, a precursor resveratrol, the most abundant form in nature. A number studies have hypothesized that piceid may same bioactivities like those resveratrol. aim this work compare with antioxidation and antiproliferation activities vitro.The antioxidative effects were evaluated by phenanthroline-Fe²⁺ method H₂O₂-induced oxidative injury cell model. determined MTT human liver tumor HepG2 cells,...
Background Polyphenols, a group of complex naturally occurring compounds, are widely distributed throughout the plant kingdom and therefore readily consumed by humans. The relationship between their chemical structure intestinal absorption, transport, first-pass metabolism remains unresolved, however. Methods Here, we investigated absorption four polyphenol apigenin, resveratrol, emodin chrysophanol, using in vitro Caco-2 cell monolayer model system situ perfusion vivo pharmacokinetic...
Renal fibrosis is widely considered a common mechanism leading to end-stage renal failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis of fibrosis. Runt-related transcription factor 1(RUNX1) vital role hematopoiesis via Endothelial-to-Hematopoietic Transition (EHT), process that conceptually similar EMT, but its EMT and unclear. Here, we demonstrate RUNX1 overexpressed processes TGF-β-induced partial expression level SMAD3-dependent. Knockdown...
Abstract With the extensive application of doxorubicin (DOX), DOX resistance has become one main obstacles to effective treatment breast cancer. In this paper, and resveratrol (RES) were co-encapsulated in a modified PLGA nanoparticle (NPS) overcome resistance. CLSM results indicated that RES simultaneously delivered into nucleus DOX-resistant human cancer cells by DOX/RES-loaded NPS. Consequently, NPS showed significant cytotoxicity on MDA-MB-231/ADR MCF-7/ADR cells. Furthermore, could...
Background Diabetes foot ulcers (DFUs) are a type of infection, ulcer, and/or deep tissue destruction caused by neuropathy and vascular disease in the distal extremities diabetic patients. Its pathogenesis its microenvironment not entirely understood. Methods Initially, GSE165816 data set from GEO database was utilized for single cell analysis to reveal functional status DFUs. The GSE199939 RNA-seq external validation. On basis logistic regression machine learning algorithm (OCLR), pseudo...
This paper offers a comprehensive overview of 3D-printed electromagnetic shielding. It covers principles, simulation/testing, 3D printing techniques, materials, and function-oriented shields. also discusses challenges future development.
1. This manuscript presents the preclinical profile of lumiracoxib, a novel cyclooxygenase-2 (COX-2) selective inhibitor. 2. Lumiracoxib inhibited purified COX-1 and COX-2 with K(i) values 3 0.06 microM, respectively. In cellular assays, lumiracoxib had an IC(50) 0.14 microM in COX-2-expressing dermal fibroblasts, but caused no inhibition at concentrations up to 30 (HEK 293 cells transfected human COX-1). 3. whole blood assay, for were 0.13 67 (COX-1/COX-2 selectivity ratio 515). 4. was...
Clinical studies have shown that the efficacy of programmed cell death receptor-1/programmed ligand-1 (PD-1/PD-L1) inhibitors on glioblastoma (GBM) is much lower than what expected because low immunogenicity GBM. Ferroptosis cancer cells can induce maturation dendritic (DC cells) and increase activity T cell. The activated release IFN-γ, which subsequently induces ferroptosis cells. Thus, aim this paper to set up a new GBM-targeted drug delivery system (Fe3O4-siPD-L1@M-BV2) boost for...
Glioblastoma (GBM) is an invasive cancer with high mortality in central nervous system. Resistance to temozolomide (TMZ) and immunosuppressive microenvironment lead low outcome of the standardized treatment for GBM. In this study, a 2-deoxy-d-glucose modified lipid polymer nanoparticle loaded TMZ siPD-L1 (TMZ/siPD-L1@GLPN/dsb) was prepared reprogram TMZ-resistant orthotopic TMZ/siPD-L1@GLPN/dsb simultaneously delivered large amount deep area GBM tissue. By inhibiting PD-L1 protein...
In this review, the 3D printing techniques on fabricating complex structures for electromagnetic wave absorbing and/or shielding, as well current challenges and future prospects, are emphatically summarized.
Ischemic stroke is one of the main causes death and disability in world. The treatment for ischemic to restore blood perfusion as soon possible. However, when brain tissue re-perfused by blood, mitochondrial permeability transition pore (mPTP) neuron microglia excessively opened, resulting apoptosis nerve inflammation. This aggravates injury. Cyclosporine A (CsA) inhibits over-opening mPTP, subsequently reducing release ROS cerebral ischemia/reperfusion injured microglia. CsA insoluble water...
Abstract Background At present, patients with myocardial infarction remain an increased risk for ischemia/reperfusion injury (MI/RI). There lacks effectively method to treat MI/RI in clinic. For the treatment of MI/RI, it is still a bottleneck deliver drug ischemic myocardium. In this paper, regulatory T cells (Tregs) biomimetic nanoparticle (CsA@PPTK) was prepared by camouflaging platelet membrane. Results CsA@PPTK actively accumulated myocardium mice. significantly scavenged reactive...
To determine whether a smartphone application based education programme can lower salt intake in schoolchildren and their families.Parallel, cluster randomised controlled trial, with schools randomly assigned to either intervention or control group (1:1).54 primary from three provinces northern, central, southern China, 15 September 2018 27 December 2019.592 children (308 (52.0%) boys; mean age 8.58 (standard deviation 0.41) years) grade 3 of school (about 11 per school) 1184 adult family...