A5013564891- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Inflammatory mediators and NSAID effects
- Traditional Chinese Medicine Analysis
- Asymmetric Hydrogenation and Catalysis
- Cardiac Ischemia and Reperfusion
- Helicobacter pylori-related gastroenterology studies
- Surface Chemistry and Catalysis
- Bone health and treatments
- Natural product bioactivities and synthesis
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Immune cells in cancer
- Asymmetric Synthesis and Catalysis
- Sirtuins and Resveratrol in Medicine
- Synthesis and Biological Activity
- Phytochemical Studies and Bioactivities
- Ginseng Biological Effects and Applications
- Microwave-Assisted Synthesis and Applications
- Mitochondrial Function and Pathology
- Metal complexes synthesis and properties
- Extracellular vesicles in disease
Air Force Medical University
2016-2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2022-2024
Shaanxi University of Chinese Medicine
2024
Chinese Academy of Sciences
2005-2010
Shanghai Institute of Materia Medica
2007-2010
American Pharmacists Association
2009
Northwest University
2007
Shanghai Institutes for Biological Sciences
2005-2007
Xijing Hospital
2005
Cyclosporin A (CsA) is a promising therapeutic drug for myocardial ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening mitochondrial permeability transition pore (mPTP). However, application cyclosporin treat MI/RI limited due immunosuppressive effect other normal organ and tissues. SS31 represents novel mitochondria-targeted peptide which can guide accumulate into mitochondria. In this paper, nanoparticles (CsA@PLGA-PEG-SS31) were prepared precisely deliver...
Background Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of combined use remains unclear. The present study was designed to investigate paeonol danshensu (representative active ingredient Milthiorrhizae, respectively) on isoproterenol-induced myocardial infarction rats its underlying mechanisms. Methodology Paeonol (80 mg kg−1) (160 were...
Abstract Paeonol and danshensu is the representative active ingredient of traditional Chinese medicinal herbs Cortex Moutan Radix Salviae Milthiorrhizae, respectively. combination (PDSS) has putative cardioprotective effects in treating ischemic heart disease (IHD). However, evidence for protective effect scarce pharmacological mechanisms remain unclear. The present study was designed to investigate PDSS on isoproterenol (ISO)-induced myocardial infarction rats elucidate potential mechanism....
The clinic therapeutic effect of resveratrol is limited due to its low oral bioavailability. Piceid, a precursor resveratrol, the most abundant form in nature. A number studies have hypothesized that piceid may same bioactivities like those resveratrol. aim this work compare with antioxidation and antiproliferation activities vitro.The antioxidative effects were evaluated by phenanthroline-Fe²⁺ method H₂O₂-induced oxidative injury cell model. determined MTT human liver tumor HepG2 cells,...
Clinical studies have shown that the efficacy of programmed cell death receptor-1/programmed ligand-1 (PD-1/PD-L1) inhibitors on glioblastoma (GBM) is much lower than what expected because low immunogenicity GBM. Ferroptosis cancer cells can induce maturation dendritic (DC cells) and increase activity T cell. The activated release IFN-γ, which subsequently induces ferroptosis cells. Thus, aim this paper to set up a new GBM-targeted drug delivery system (Fe3O4-siPD-L1@M-BV2) boost for...
Glioblastoma (GBM) is an invasive cancer with high mortality in central nervous system. Resistance to temozolomide (TMZ) and immunosuppressive microenvironment lead low outcome of the standardized treatment for GBM. In this study, a 2-deoxy-d-glucose modified lipid polymer nanoparticle loaded TMZ siPD-L1 (TMZ/siPD-L1@GLPN/dsb) was prepared reprogram TMZ-resistant orthotopic TMZ/siPD-L1@GLPN/dsb simultaneously delivered large amount deep area GBM tissue. By inhibiting PD-L1 protein...
Ischemic stroke is one of the main causes death and disability in world. The treatment for ischemic to restore blood perfusion as soon possible. However, when brain tissue re-perfused by blood, mitochondrial permeability transition pore (mPTP) neuron microglia excessively opened, resulting apoptosis nerve inflammation. This aggravates injury. Cyclosporine A (CsA) inhibits over-opening mPTP, subsequently reducing release ROS cerebral ischemia/reperfusion injured microglia. CsA insoluble water...
Abstract Background At present, patients with myocardial infarction remain an increased risk for ischemia/reperfusion injury (MI/RI). There lacks effectively method to treat MI/RI in clinic. For the treatment of MI/RI, it is still a bottleneck deliver drug ischemic myocardium. In this paper, regulatory T cells (Tregs) biomimetic nanoparticle (CsA@PPTK) was prepared by camouflaging platelet membrane. Results CsA@PPTK actively accumulated myocardium mice. significantly scavenged reactive...
Abstract Glioma is easy to develop resistance temozolomide (TMZ). TMZ-resistant glioma secretes interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), recruiting regulatory T cell (T reg ) inhibiting the activity of cells natural killer (NK cell), subsequently forming an immunosuppressive microenvironment. Oxaliplatin (OXA) greatly inhibits proliferation cells, but ability OXA cross blood–brain barrier (BBB) weak. Thus, therapeutic effect on not satisfactory. Transferrin receptor 1...
Abstract Background and Purpose Liver fibrosis is a wound‐healing reaction which the main cause of chronic liver diseases worldwide. The activated hepatic stellate cell (aHSC) driving factor in development fibrosis. Inhibiting autophagy aHSC can prevent progression fibrosis, but inhibiting other cells has opposite effects. Hence, targeted inhibition quite necessary for treatment prompts us to explore delivery system small molecule inhibitor hydroxychloroquine (HCQ) that target alleviate...
Genistein (4′,5,7-trihydroxyisoflavone), a naturally occurring phenolic compound, possesses well-known preventive activity in breast and prostate cancer, cardiovascular diseases, postmenopausal problems. The aim of this study is to investigate the distribution dose-dependent absorption, metabolism, excretion genistein rats. was orally administered rats at different doses. At various time intervals, blood, bile, urine samples were collected incubated with glucuronidase hydrolyze...
Bone is an especially prone metastatic site for breast cancer, and to block the vicious cycle between bone resorption tumor growth important strategy treatment of cancer metastasis. In this paper, pH- redox-sensitive as well metastasis-targeting nanoparticles (DOX@ALN-(HA-PASP)CL) were prepared, also their anti-tumor activity anti-bone effect investigated in detail. The vitro experimental results indicated that DOX released from DOX@ALN-(HA-PASP)CL exhibited a GSH-, DTT- pH-dependent manner....
A PEG-based, folate mediated, active tumor targeting drug delivery system using DOX-hyd-PEG-FA nanoparticles (NPs) were prepared. NPs showed a significantly faster DOX release in pH 5.0 medium than 7.4 medium. Compared with DOX-hyd-PEG NPs, increased the intracellular accumulation of and translocation from lysosomes to nucleus. The cytotoxicity on KB cells was much higher that free DOX, DOX-ami-PEG-FA NPs. attenuated presence exogenous folic acid. IC50 A549 no significant difference. After...
Abstract In order to overcome drug resistant and enhance antitumor activity of DOX, a new pH-sensitive micelle (DOX/DQA-DOX@DSPE-hyd-PEG-AA) was prepared simultaneously deliver DOX nucleus mitochondria. Drug released from DOX/DQA-DOX@DSPE-hyd-PEG-AA showed pH-dependent manner. induced the depolarization mitochondria apoptosis in MDA-MB-231/ADR cells A549 cells, which resulted high cytotoxicity against cells. Confocal microscopy confirmed that delivered DQA-DOX tumor cell. After injected...
Abstract Chemotherapy and immunotherapy have shown no significant outcome for unresectable pancreatic ductal adenocarcinoma (PDAC). Multi-drug combination therapy has become a consensus in clinical trials to explore how arouse anti-tumor immunity meanwhile overcome the poorly tumoricidal effect stroma barrier that greatly hinders drug penetration. To address this challenge, comprehensive strategy is proposed fully utilize both ferroptotic vulnerability of PDAC potently irritate...