A5103076636- Plant biochemistry and biosynthesis
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Plant Gene Expression Analysis
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Biochemical and biochemical processes
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Lung Cancer Diagnosis and Treatment
- Plant and animal studies
- Neural dynamics and brain function
- Metabolomics and Mass Spectrometry Studies
- Cardiac Ischemia and Reperfusion
- Ginseng Biological Effects and Applications
- Ginger and Zingiberaceae research
- Advanced Memory and Neural Computing
- Medicinal Plants and Bioactive Compounds
- Vascular Procedures and Complications
- Adipose Tissue and Metabolism
- Electron Spin Resonance Studies
- Medical Imaging and Pathology Studies
Xuzhou Central Hospital
2022-2025
Hangzhou Dianzi University
2024-2025
Shenyang Pharmaceutical University
2025
Air Force Medical University
2013-2023
Xuzhou Medical College
2022-2023
Academy of Emergency Medicine and Care
2022
Guangzhou University of Chinese Medicine
2019-2021
State Council of the People's Republic of China
2015
South China Institute of Collaborative Innovation
2014
Xinjiang Institute of Materia Medica
2010
Background Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of combined use remains unclear. The present study was designed to investigate paeonol danshensu (representative active ingredient Milthiorrhizae, respectively) on isoproterenol-induced myocardial infarction rats its underlying mechanisms. Methodology Paeonol (80 mg kg−1) (160 were...
Background Currently, the computed tomography (CT) radiomics-based models, which can evaluate small (≤ 20 mm) solid pulmonary nodules (SPNs) are lacking. This study aimed to develop a CT model that differentiate between benign and malignant SPNs. Methods included patients with SPNs January 2019 November 2021. The participants were then randomly categorized into training testing cohorts an 8:2 ratio. images of all analyzed extract radiomics features. Furthermore, scoring was developed based...
Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease.Although several hypotheses have been proposed to explain pathogenesis of PD, apoptotic cell death and oxidative stress are mechanisms.Tetramethylpyrazine (TMP) a biological component that has extracted from Ligusticum wallichii Franchat (ChuanXiong), which exhibits anti-apoptotic antioxidant roles.In current study, we aimed investigate possible protective effect TMP against dopaminergic neuron injury...
The current study was to evaluate the anti-thrombotic effect of alpha-linolenic acid (ALA) which isolated and purified from Jiaomu in vivo. seeds were crushed subsequently subjected saponification, hydrolysis, gradient freezing, urea inclusion complexation silver nitrate obtain unsaturated fatty acids. chemical characteristics ALA validated by 1HNMR, 13CNMR mass spectrometry, then its mixture with linoleic (1:1) evaluated following experiments. through our newly established methods. can...
Pogostemon cablin (Blanco) Benth. (Patchouli) is an important aromatic and medicinal plant widely used in traditional Chinese medicine as well the perfume industry. Patchoulol primary bioactive component P. cablin, its biosynthesis has attracted widespread interests. Previous studies have surveyed putative genes involved patchoulol using next-generation sequencing method; however, technical limitations generated by short-read restrict yield of full-length genes. Additionally, little known...
Abstract 2,3,5,4′‐Tetrahydroxystilbene‐2‐ O ‐β‐ d ‐glucoside (TSG) has been shown to protect human umbilical vein endothelial cells (HUVECs) from lysophosphatidylcholine (LPC)‐induced injury; however, the underlying molecular mechanism remains be determined. The aim of this study was investigate protective TSG against LPC‐induced injury in HUVECs. We established a stable cell model by treating HUVECs with various concentrations LPC and found 10.0 µg/mL optimal for inducing injury. effects on...
Abstract: Liposomes constitute one of the most popular nanocarriers for improving delivery and efficacy agents in cancer patients. The purpose this study was to design evaluate immunoliposome co-delivery bufalin anti-CD40 induce synergetic therapeutic while eliminating systemic side effects. Bufalin liposomes (BFL) conjugated with antibody (anti-CD40-BFL) showed enhanced cytotoxicity compared alone. In a mouse B16 melanoma model, intravenous injection anti-CD40-BFL achieved smaller tumor...
Autophagy exists in vascular endothelial cells, but the relationship between autophagy and blood vessel dysfunction hypertension remains elusive. This study aimed to investigate role of prehypertension underlying mechanisms involved. Furthermore, we sought determine if how tetrahydroxystilbene glucoside (TSG), a resveratrol analogue active ingredient Polygonum multiflorum Thunb used for its cardiovascular protective properties traditional Chinese medicine, influences function. Male...
<em>Paris</em> saponin H (PSH) is a type of steroid derived from Rhizoma Paridis (RP; the rhizome <em>Paris</em>). In our previous studies, saponins RP exerted antiglioma activity <em>in vitro</em>. However, effects PSH on glioma have not been elucidated. The aim present study was to evaluate U251 glioblastoma cells and elucidate possible underlying mechanism. were treated with at various concentrations for 48 h, cell viability, invasion, apoptosis cycle progression assessed using specific...
The purpose of this study was to determine the therapeutic effect salvianolic acid b and paeonol on coronary disease. ischemia myocardial animal model is induced by administering pituitrin (20 μg·kg(-1)) intravenously via abdominal vein. A combination (CSAP) (5, 10 15 mg/kg BW) administrated experimental rabbits. Biochemical indices were evaluated during six weeks intervention. We found that compound can markedly dose-dependently reduce fibrinogen malonaldehyde levels, increase HDL level,...
Abstract Lysophosphatidylcholine (LPC) induces inflammation in endothelial cells (ECs) but the mechanism is not fully understood. The Notch signaling pathway involved chronic EC inflammation, its functions LPC‐induced inflammatory damage and 2,3,5,4′‐tetrahydroxystilbene‐2‐ O ‐β‐ d ‐glucoside's (TSG) protective effect during human umbilical vein (HUVECs) largely unknown. We report that activation contributed to injury HUVECs, TSG protected HUVECs from by antagonizing LPC. γ‐secretase...
Lysine succinylation is a novel, naturally occurring posttranslational modification (PTM) in living organisms. Global lysine identification has been performed at the proteomic level various species; however, study of plant species relatively limited. Patchouli (P. cablin (Blanco) Benth., Lamiaceae) globally important industrial and medicinal herb. In present study, succinylome analysis was carried out patchouli plants to determine potential regulatory role growth, development, physiology....
Abstract Background Glioma is a common primary central nervous system tumour, and therapeutic drugs that can effectively improve the survival rate of patients in clinic are lacking. Bufalin effective treating various tumours, but mechanism by which it promotes apoptosis glioma cells unclear. The aim this study was to investigate drug targets bufalin clarify apoptotic mechanism. Methods Cell viability proliferation were evaluated CCK-8 colony formation assays. Then, cell cycle apoptosis,...
One of the leading causes death in world is cerebrovascular disease. Numerous Chinese traditional medicines, such as Cortex Moutan (root bark Paeonia suffruticosa Andrew) and Radix Salviae miltiorrhizae rhizome Salvia miltiorrhiza Bunge), protect against diseases exhibit anti-atherosclerotic effects. Traditional medicines have been routinely used for a long time China. In addition, these two herbs are prescribed together clinical practice. Therefore, pharmacodynamic interactions between...
Bufalin was reported to show strong pharmacological effects including cardiotonic, antiviral, immune-regulation, and especially antitumor effects. The objective of this study determine the characterization, efficacy, pharmacokinetics bufalin-loaded PEGylated liposomes compared with bufalin entity, which were prepared by FDA-approved pharmaceutical excipients. Bufalin-loaded reproducibly homogeneous particle size combination thin film evaporation method high-pressure homogenization method....
Tetrahydroxystilbene glucoside (THSG) is one of the active ingredients Polygonum multiflorum. It has been shown to exert a variety pharmacological effects, including antioxidant, anti-aging, and anti-atherosclerosis. Because its prominent anti-inflammatory effect, we explored whether THSG had analgesic effect. In this study, used model chronic inflammatory pain caused by injecting complete Freund’s adjuvant into hind paw mice. We found relieved swelling in mice on dose-dependent manner....