A5046132791- Marine Biology and Environmental Chemistry
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Marine Sponges and Natural Products
- RNA modifications and cancer
- Microbial Natural Products and Biosynthesis
- Marine Ecology and Invasive Species
- Environmental Toxicology and Ecotoxicology
- Circular RNAs in diseases
- Microbial Community Ecology and Physiology
- Marine Biology and Ecology Research
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Peroxisome Proliferator-Activated Receptors
- Aquaculture disease management and microbiota
- Bacterial biofilms and quorum sensing
- Coral and Marine Ecosystems Studies
- Fungal Biology and Applications
- Epigenetics and DNA Methylation
- Plant Pathogens and Fungal Diseases
- Ubiquitin and proteasome pathways
- Liver Disease Diagnosis and Treatment
- Plant-Microbe Interactions and Immunity
Shenzhen University
2015-2025
Tongren Hospital
2017-2025
Shanghai Jiao Tong University
2013-2025
Wenzhou Medical University
2021-2025
Shanghai First People's Hospital
2024-2025
Dalian University
2025
First Affiliated Hospital of Henan University of Science and Technology
2025
Dalian University of Technology
2025
Air Force Medical University
2016-2024
Peking University Shougang Hospital
2024
Abstract As a terpenoids natural product isolated from the plant Thunder God Vine , Celastrol is widely studied for its pharmacological activities, including anti-tumor activities. The clinical application of strictly limited due to severe side effects, whereas previously revealed targets and mechanism seldom reduce in vivo toxicity via structural optimization. Target identification has far-reaching influence on development innovative drugs, omics data been used unbiased target prediction....
The anti-neoplastic agent didemnin B from the Caribbean tunicate Trididemnum solidum was first marine drug to be clinically tested in humans. Because of its limited supply and complex cyclic depsipeptide structure, considerable challenges were encountered during B's development that continue limit aplidine (dehydrodidemnin B), which is currently being evaluated numerous clinical trials. Herein we show didemnins are bacterial products produced by α-proteobacteria Tistrella mobilis bauzanensis...
Three new 14-membered resorcylic acid lactones, two with a rare natural acetonide group and one 5-chloro-substituted lactone, named cochliomycins A−C (1−3), together four known analogues, zeaenol (4), LL-Z1640-1 (5), LL-Z1640-2 (6), paecilomycin F (7), were isolated from the culture broth of Cochliobolus lunatus, fungus obtained gorgonian Dichotella gemmacea collected in South China Sea. Their structures relative configurations 1−3 elucidated using comprehensive spectroscopic methods...
Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (−)-sydonol (2), (−)-sydonic acid (3), and (−)-5-(hydroxymethyl)-2-(2′,6′,6′-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) together with one known fungal metabolite (5) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was sponge Xestospongia testudinaria collected South China Sea. them (1–4) are optically active compounds. Their structures absolute configurations elucidated by using...
Abstract Bacilli are ubiquitous low G+C environmental Gram-positive bacteria that produce a wide assortment of specialized small molecules. Although their natural product biosynthetic potential is high, robust molecular tools to support the heterologous expression large gene clusters in Bacillus hosts rare. Herein we adapt transformation-associated recombination (TAR) yeast design single genomic capture and vector for antibiotic production subtilis . After validating this direct cloning...
Background: microRNAs (miRNAs) are small non-coding RNAs and have been shown to play a crucial role in the colorectal cancer (CRC) tumorigenesis progression. The aim of this study was investigate clinical significance prognostic value miR-140-5p CRC. exact functions underlying molecular mechanisms CRC further determined. Methods: expression detected samples, their adjacent nontumor tissues as well cell lines by RT-qPCR. Cell proliferation using CCK-8, invasion migration were evaluated...
An accurate assessment of pressure injury healing is crucial for the timely implementation nursing intervention. This study aimed to investigate accuracy infrared thermography-based wound temperature measurement in predicting outcomes. prospective, 16 days observational included 156 adults with injury. The bed, periwound skin and normal was recorded by using thermography every three days. After that, relative temperatures PI were analyzed. aim assess significance outcomes injuries. Relative...
To find associations between the prevalence of low back pain and occupational activities.Interviews a random sample 5185 19-59 year old Danish employees analysed by logistic regression.Increased risks were found for "vibration affecting whole body" (odds ratio (OR) = 1.28), "physically hard work" (OR "frequently twisting or bending" 1.71), "standing up" 1.20), "concentration demands" 1.28). In analysis dose-response relations risk factors, one period increased with increasing exposure time...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 238:173-186 (2002) - doi:10.3354/meps238173 Exposure and potential food chain transfer factor of Cd, Se Zn in marine fish Lutjanus argentimaculatus Yan Xu, Wen-Xiong Wang* Department Biology, Hong Kong University Science Technology (HKUST), Clear Water Bay, Kowloon, SAR *Corresponding author. E-mail:...
Modern antifouling coatings use heavy metals and toxic organic molecules to prevent biofouling, the undesirable growth of marine organisms on man-made substrata. In an ongoing survey deep-sea microorganisms aimed at finding low metabolites, actinomycete bacterium was isolated from Pacific sediment depth about 5000 m. The closely related Streptomyces fungicidicus (99% similarity) according 16S ribosomal RNA sequence information. spent culture medium this inhibited barnacle larval attachment....
Abstract Long noncoding RNAs (lncRNA) are attractive biomarkers and therapeutic targets because of their disease‐ stage‐restricted expression. Small nucleolar RNA host gene 17 (SNHG17) belongs to a large family genes hosting small RNAs, with its expression pattern biological function not clarified in gastric cancer (GC). Thus, we conducted this study investigate the functional significance underlying mechanisms SNHG17 GC progression. Our results showed that was upregulated tissues cells,...
Umbilical cord-derived mesenchymal stem cell (UCMSCs) transplantation has been widely studied in premature ovarian failure (POF). However, the underlying mechanism remains elusive. This study aims to investigate protective properties and mechanisms of heme oxygenase-1 (HO-1) expressed UCMSCs restoring function POF mice.In vitro vivo experiments, mice were treated with presence or absence HO-1/shHO-1-transfected UCMSCs, administration SP600125 anisomycin, inhibitor activator JNK. The...
Background/Aims: Emerging evidence points towards an important role of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression gastric cancer (GC). MT1JP has recently been reported to be differentially expressed act as a tumor suppressor different tumors, with its mechanisms not fully understood GC. Methods: RT-qPCR was used detect expression MT1JP, miR-214-3p RUNX3 tissues cell lines The CCK-8 assay, colony formation, Transwell assay wound healing were evaluate proliferation,...