A5101495087- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Molecular Sensors and Ion Detection
- Lipid metabolism and disorders
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Plant Diversity and Evolution
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Luminescence and Fluorescent Materials
- Cancer-related gene regulation
- Plant and Fungal Species Descriptions
- Adipose Tissue and Metabolism
- Plant Taxonomy and Phylogenetics
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Genetic Syndromes and Imprinting
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Prenatal Substance Exposure Effects
- Phytochemical Studies and Bioactivities
Xi'an Jiaotong University
2020-2025
Hubei University of Arts and Science
2018-2024
Xiangyang Central Hospital
2018-2024
Wuhan University of Science and Technology
2024
Ministry of Public Security of the People's Republic of China
2022
First Affiliated Hospital Zhejiang University
2022
Nanjing Medical University
2021
Jiangsu Province Hospital
2021
Zhejiang University
2013-2021
The University of Texas Health Science Center at San Antonio
2014-2016
Abstract NEAT1 is an important tumor oncogenic gene in various tumors. Nevertheless, its involvement remains poorly studied cervical cancer. Our study explored the functional mechanism of level several cancer cells was quantified and we found greatly upregulated vitro. knockdown inhibited development through repressing cell proliferation, colony formation, capacity migration, invasion also inducing apoptosis. For another, microRNA (miR)‐133a downregulated negatively modulated miR‐133a...
Scope Hepatic steatosis and insulin resistance (IR) are risk factors for many metabolic syndromes such as NAFLD T2DM. ApoA4 improves glucose hemostasis by increasing glucose‐stimulated secretion uptake via PI3K‐Akt activation in adipocytes. However, whether has an effect on hepatic or IR remains unclear. Methods results ApoA4‐knockout (KO) aggravates diet‐induced obesity, steatosis, mice promoted increased lipogenesis gene expression based RNA‐seq data. Conversely, liver‐specific...
Gene expression data using retrieved ovarian cancer (OC) samples were used to identify genes of interest and a support vector machine (SVM) classifier was subsequently established predict the recurrence OC. Three datasets (GSE17260, GSE44104 GSE51088) investigating OC gene downloaded from Expression Omnibus. Differentially expressed (DEGs) in patients with non‑recurrent recurrent revealed via homogeneity test quality control analysis. A protein‑protein interaction (PPI) network for DEGs...
Discs large‑associated protein 5 (DLGAP5) is a microtubule‑associated and reported to exert oncogenic role in tumorigenesis, including lung cancer hepatocellular carcinoma. However, the prognostic value biological function of DLGAP5 ovarian (OC) still remain unclear. The present study investigated expression pattern by searching Oncomine microarray database. correlation between survival prognosis OC patients was analyzed online tool KM‑plotter. Knockdown achieved transfection with small...
A new kind of hydrophilic copolymer poly(HEMA-co-VNP) was designed and synthesized by the radical copolymerization 2-hydroxyethylmethacrylate (HEMA) 2-{[2-(4-vinylbenzyloxy)naphthalen-1-yl]methyleneamino}-(S)-2-phenylethanol (VNP). The desired showed a highly selective red-shifted emission unique chiroptical response upon HSO4− binding in organic solution. UV-vis 1H NMR spectroscopic studies revealed that hydrogen bonding between imine moiety VNP repeating units is crucial for high...
Abstract Cervical cancer continues to be a major public health problem. Although long noncoding RNAs (lncRNAs) were involved in the initiation and progression of cancer, few studies focus on lncRNAs cervical cancer. Here, we systematically studied clinical information, transcriptome profiling, methylation array data squamous cell carcinoma endocervical adenocarcinoma that retrieved from genomic commons (GDC). Compared with protein‐coding genes, expression levels pseudogenes much lower. A...
The liver immune microenvironment is a key element in the development of hepatic inflammation NAFLD. ApoA4 deficiency increases lipid burden, insulin resistance, and metabolic inflammation. However, effect on cells precise cell subsets that exacerbate fatty remain elusive. aim this study was to profile affected by NAFL. We performed scRNA-seq from WT ApoA4-deficient mice administered high-fat diet. Immunostaining qRT-PCR analysis were used validate results scRNA-seq. identified 10 discrete...
Abstract The genus Wisteria (Fabaceae) is disjunctly distributed in eastern Asian and North American temperate deciduous forests, it widely cultivated around the world as spectacular garden plants. It a member of inverted repeat‐lacking clade (IRLC). IRLC Species are characterized by loss an IR region their plastomes, which has long been great interest. In this research, we report whole plastome sequences from all four species Wisteriopsis japonica , combining these with existing data to...
Ovarian cancer (OC) is associated with a poor prognosis due to difficulties in early detection. The aims of the present study were construct recurrence risk prediction model and reveal important OC genes or pathways. RNA sequencing data was obtained for 307 samples, corresponding clinical downloaded from Cancer Genome Atlas database. Additionally, two validation datasets, GSE44104 (20 recurrent 40 non‑recurrent samples) GSE49997 (204 samples), Gene Expression Omnibus Differentially expressed...
Methamphetamine (METH) is a highly addictive psychostimulant that causes physical and psychological damage immune system disorder, especially in the liver, which contains significant number of cells. Dopamine, key neurotransmitter METH addiction regulation, plays crucial role this process. In study, we developed chronic administration model conducted single-cell RNA sequencing to investigate effect on liver cells involvement dopamine receptor D1 (DRD1) Our findings revealed exposure induced...
Tulipa L. (Liliaceae) is among the world's most beloved and economically important ornamental bulbs. Here, we reported first chloroplast genome sequence of Tulipa. The plastome T. altaica 146,887 bp in length, including a large single-copy (LSC) 78,433 bp, small (SSC) 16,628 pair inverted repeat regions (IRa IRb) 25,913 bp. It contains 111 unique genes consisting 77 protein-coding genes, 30 tRNA four rRNA genes. phylogenetic analysis revealed that sister to clade formed by Erythronium Amana.
A novel AB type of clickable monomer, (S)-2-[(2-azido-1-phenylethylimino)methyl]-5-propargyloxyphenol (AMPP) was designed and polymerized to yield a class main-chain chiral poly(imine-triazole)s through the metal-free click reaction. With thermally induced polymerization, desired polytriazoles can be easily prepared in high yields by stepwise heating-up process have number-average molecular masses ranging from 5.1 × 103 58.1 (polydispersity indices = 1.38−1.68). The polymers were...
Abstract Long non‐coding RNAs have been reported to play crucial roles in tumorigenesis including cervical cancer. LINC00037 has identified as a significant regulator several cancers. Our study was aimed investigate the function of cancer progression. significantly downregulated human cells (HeLa, HCC94, HT‐3, Caski, and SiHa cells) compared with ectocervical epithelial (End1/E6E7 cells). Overexpression able inhibit cell proliferation, induce apoptosis, restrain migration/invasion capacity....
Background One of the pathological characteristics obesity is fat accumulation skeletal muscles (SKM) and myocardium, involving mechanisms insulin resistance abnormal lipid metabolism. Apolipoprotein A-IV (ApoA-IV) an essential gene in both glucose metabolisms.Materials methods Using high-fat diet (HFD) induced obese apoA-IV-knockout mice subsequent introduction exogenous recombinant-ApoA-IV protein adeno-associated virus (AAV)-transformed apoA-IV, we examined metabolism indicators SKM which...
<title>Abstract</title> circRNAs are reported to demonstrate significant function in various cancers. Nevertheless, the detailed effects of cervical cancer development seldom displayed. In our present research, we observed circ_0025202 was strongly overexpressed tissues and cells. Meanwhile, expression tissue samples positively associated with FIGO stage lymphnode metastasis. Then, it proved that knockdown obviously restrained cell growth while triggered apoptosis. addition, demonstrated...