A5101707261- Chinese history and philosophy
- Astro and Planetary Science
- Geomagnetism and Paleomagnetism Studies
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Solar and Space Plasma Dynamics
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Winter Sports Injuries and Performance
- Inflammatory Biomarkers in Disease Prognosis
- Soil Carbon and Nitrogen Dynamics
- Pharmacological Effects of Natural Compounds
- Soil and Water Nutrient Dynamics
- Extracellular vesicles in disease
- Sports, Gender, and Society
- Hong Kong and Taiwan Politics
- Environmental law and policy
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Climate change and permafrost
Beijing YouAn Hospital
2021-2025
Institute of Process Engineering
2025
Capital Medical University
2021-2025
Institute of Urban Environment
2024
Chinese Academy of Sciences
2024
CAS Key Laboratory of Urban Pollutant Conversion
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Zhejiang University
2002-2023
Gansu Agricultural University
2020-2023
Human menstrual blood-derived stem cells (MenSCs) are a novel source of MSCs that provide the advantage being easy to collect and isolate. Exosomes contain some mRNAs adhesion molecules can potentially impact cellular animal physiology. This study aimed investigate therapeutic potential MenSC-derived exosomes (MenSC-Ex) on AML12 (in vitro) D-GalN/LPS-induced FHF mice vivo). Transmission electron microscopy Western blot were used identify MenSC-Ex. Antibody array was examine cytokine levels...
Abstract Mesenchymal stem cells (MSCs) may have potential applications in regenerative medicine for the treatment of chronic liver diseases (CLDs). Human menstrual blood is a novel source MSCs, termed blood-derived (MenSCs). Compared with bone marrow MenSCs exhibit higher proliferation rate and they can be obtained through simple, safe, painless procedure without ethical concerns. Although therapeutic efficacy has been explored some diseases, their effects on fibrosis are still unclear. In...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity mortality. Menstrual blood-derived stem cells (MenSCs) have been shown to be good therapeutic tools in diseases such as ovarian failure cardiac fibrosis. However, relevant studies of MenSCs ALI not yet proceeded. We hypothesized that MenSC could attenuate the inflammation lipopolysaccharide (LPS)-induced promote repair damaged lung. model was induced by LPS C57 mice, saline or were...
Abstract Background In tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly compromised by drug resistance. Consequently, finding an effective solution to overcome resistance becomes crucial. Reactive oxygen species (ROS) are a group highly active molecules that play important roles in targeted cancer therapy including therapy. this review, we concentrate on ROS-associated mechanisms lethality tumors and...
Background Approximately 8.3–15.9% of patients with clinical stage I non‐small cell lung cancer are subsequently shown to have lymph node metastasis. However, the characteristics metastasis in China not fully understood. Methods This is a multicenter retrospective analysis pathological T1 who underwent surgical resection from 2 January 2014 27 December 2017. Clinical and information was collected assistance Large‐scale Data Analysis Center Cancer Precision Medicine‐LinkDoc database. The...
ABSTRACT The mass-balance of Muztag Ata No. 15 (MZ15) glacier in the eastern Pamir is reconstructed between 1980 and 2012 using an energy-based model. results show that this has been characterized by obvious interannual changes during 1980–2012 with a slightly positive mass balance 1998–2012. Precipitation ablation season primary driver these fluctuations. Distinct MZ15 1980–1997 1998–2012 are thought to be associated regionally averaged meridional wind speed corresponding precipitation...
Abstract Cervical cancer continues to be a major public health problem. Although long noncoding RNAs (lncRNAs) were involved in the initiation and progression of cancer, few studies focus on lncRNAs cervical cancer. Here, we systematically studied clinical information, transcriptome profiling, methylation array data squamous cell carcinoma endocervical adenocarcinoma that retrieved from genomic commons (GDC). Compared with protein‐coding genes, expression levels pseudogenes much lower. A...
BACKGROUND: Tribbles pseudokinase 3 (TRIB3) is a member of the tribbles-related family, which involved lot cellular processes and multiple cancers, such as breast cancer, colorectal renal cell carcinomas, lung cancer. However, expression pattern biological function TRIB3 in hepatocellular carcinoma (HCC) has not yet been completely elucidated. METHODS: The clinicopathological characteristics were evaluated by HCC tissue microarray qPCR analysis. Lentivirus packaging transfection employed to...
Despite many advances in conventional treatment strategies, there is no effective modality for malignant gliomas. Gene therapy may offer a promising option gliomas and several gene approaches have shown anti-tumor efficiency previous studies. Mesenchymal stem cell-based therapies, which cells are genetically engineered to express therapeutic molecules, tremendous potential because of their innate homing ability. In this study, human menstrual blood-derived MSCs (MenSC), novel type...
Cluster of differentiation (CD)47, which acts as a negative indicator for phagocytic cells, is overexpressed on the surface multiple human solid tumor cell types. Avoiding phagocytosis by CD47 required progression tumors. The present study investigated expression in oral leukoplakia (OLK) and squamous carcinoma (OSCC), preliminarily explored impact proliferation OSCC cells. A total 56 tissue samples, including 36 cases OLK, 10 normal mucosa (NOM) were selected to detect immunohistochemistry....
The coxsackie and adenovirus receptor (CAR) is considered a tumor suppressor critical factor for the efficacy of therapeutic strategies that employ adenovirus. However, data on CAR expression levels in colorectal cancer are conflicting its clinical relevance remains to be elucidated. Immunohistochemistry was performed tissue microarrays containing 251 pairs colon adjacent normal samples from Chinese Han patients assess CAR. Compared with healthy mucosa, decreased (40.6% vs. 95.6%; P<0.001)...
LDH‐C 4 is a lactate dehydrogenase that catalyzes the interconversion of pyruvate with lactate. In mammals the, Ldh‐c gene was originally thought to be expressed only in testis and spermatozoa. Plateau pika ( Ochotona curzoniae ), belonging genus Ochotonidea family, hypoxia tolerant mammal living at 3000–5000 m above sea levelon Qinghai‐Tibet Plateau. We found expression pattern six LDH isoenzymes somatic tissues female male plateau pikas same as those sperm, suggesting pika. Here we report...
A comparative study was conducted to investigate the adsorption characteristics of phosphorus (P) on two soil samples collected from a typical subtropical reservoir and reveal possible influence alternating exposure inundation P onto in water level fluctuation zone. Short‐term batch experiments were performed, characterization methods, such as scanning electron microscopy (SEM) Fourier transform infrared (FT‐IR) spectroscopy, also used. The kinetics for both soils best described by...
Caspase 6 (CASP6) is a neuron degeneration-related protease and widely considered to be potential drug-design target against neurodegenerative diseases such as Huntington's disease Alzheimer's disease. The N-terminal pro-peptide of CASP6, also referred the pro-domain, contains 23 residues its functional role remains elusive. In this study, crystal structure full-length CASP6 zymogen mutant, proCASP6H121A, was solved. Although pro-domain flexible in crystal, without visible electron density,...