A5100344256- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Sirtuins and Resveratrol in Medicine
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Asymmetric Synthesis and Catalysis
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Electron Spin Resonance Studies
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Chemical Synthesis and Analysis
- Muscle Physiology and Disorders
- Advanced biosensing and bioanalysis techniques
- Phytochemicals and Antioxidant Activities
- RNA Interference and Gene Delivery
- Stress Responses and Cortisol
- Genomics, phytochemicals, and oxidative stress
- Ear and Head Tumors
Air Force Medical University
2011-2024
Riverside Hospital of Guangxi Zhuang Autonomous Region
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
Guangzhou Chest Hospital
2024
Stowers Institute for Medical Research
2010-2024
Yangzhou University
2024
Beijing Chao-Yang Hospital
2024
Capital Medical University
2013-2024
Shanxi University
2023
Gallic acid (3,4,5-trihydroxybenzoic acid, GA) is a phenolic compound found in many medicinal plants traditionally used China or patent medicine such as Feiyangchangweiyan capsule (FY capsule) for the treatment of gastrointestinal diseases decades. However, evidence gastroprotective effect GA deficient and pharmacological mechanisms remain limited. The present investigation was initiated to demonstrate understand potential underlying mechanism on ethanol-induced gastric ulcer rats. Gastric...
Background Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of combined use remains unclear. The present study was designed to investigate paeonol danshensu (representative active ingredient Milthiorrhizae, respectively) on isoproterenol-induced myocardial infarction rats its underlying mechanisms. Methodology Paeonol (80 mg kg−1) (160 were...
The innate antiviral response is mediated, at least in part, by Toll-like receptors (TLRs). TLR3 signaling activated to viral infection, and the absence of mice significantly increases mortality after infection with enteroviruses that cause myocarditis and/or dilated cardiomyopathy. We screened patients diagnosed enteroviral myocarditis/cardiomyopathy identified a rare variant one patient as well increased occurrence common polymorphism compared controls. Expression either resulted reduced...
Abstract Paeonol and danshensu is the representative active ingredient of traditional Chinese medicinal herbs Cortex Moutan Radix Salviae Milthiorrhizae, respectively. combination (PDSS) has putative cardioprotective effects in treating ischemic heart disease (IHD). However, evidence for protective effect scarce pharmacological mechanisms remain unclear. The present study was designed to investigate PDSS on isoproterenol (ISO)-induced myocardial infarction rats elucidate potential mechanism....
Hyperglycemia-induced oxidative stress and fibrosis play a crucial role in the development of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), major bioactive metabolite natural antioxidant curcumin, is reported to exert even more effective antioxidative superior antifibrotic properties as well anti-inflammatory antidiabetic abilities. This study was designed investigate potential protective effects THC on experimental DCM its underlying mechanisms, pointing high glucose-induced...
Inflammation plays a key role in the pathophysiology of ischemic stroke. Some proinflammatory mediators, such as cytokines and chemokines, are produced Chemokine-like factor 1 (CKLF1), novel C-C chemokine, displays chemotactic activities wide spectrum leukocytes an important brain development. In previous studies, we have found that expression CKLF1 increased rats after focal cerebral ischemia treatment with antagonist C19 peptide decreased infarct size water content. However, stroke is...
The protective effects of dioscin, a natural steroidal saponin from some medicinal plants including Dioscorea nipponica Makino, against lipopolysaccharide (LPS)- induced acute liver and renal damages have been reported in our previous works. However, its effect on LPS-induced lung injury (ALI) remains unknown. In the present study, possible mechanisms dioscin ALI vitro vivo were investigated. results showed that effectively inhibited cell proliferation markedly decreased reactive oxidative...
Tumor-initiating stem cells (TSCs) are critical for drug resistance and immune escape. However, the mutual regulations between TSC tumor microenvironment (TME) remain unclear. Using DNA-label retaining, single-cell RNA sequencing (scRNA-seq), other approaches, we investigated intestinal adenoma in response to chemoradiotherapy (CRT), thus identifying therapy-resistant TSCs (TrTSCs). We find bidirectional crosstalk TME using CellPhoneDB analysis. An intriguing finding is that shape into a...
In order to perform their normal physiological functions, it is important that cells maintain the intracellular pH within range. Intracellular enzyme activity, cytoskeleton component integration, and cellular growth differentiation rates are all closely associated with pH. It has been demonstrated in nervous system diseases, such as ischemic stroke, traumatic brain injury, epilepsy, Parkinson's disease, Alzheimer's disease (AD), common characteristics decreased or acidosis at both tissular...
Abstract In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these on HCT 116 cells including levels singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis expression apoptosis-related proteins. The results corroborated that synchronous action radiation enhance generation cytotoxic...
Radiation resistance poses a major clinical challenge in breast cancer (BC) treatment, but little is known about how long noncoding RNA (lncRNA) may regulate this phenomenon. Here, we reported that DUXAP8 was highly expressed radioresistant BC tissues, and high expression of associated with poor prognosis. We found the overexpression promoted radioresistance, while knockdown increased radiosensitivity. Further studies revealed enhanced radioresistance cells by activating PI3K/AKT/mTOR...
Abstract Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy in United States. EZH2 silences gene expression through trimethylating lysine 27 on histone H3 (H3K27Me3). is often overexpressed EOC and has been suggested as a target for intervention. However, genes remain poorly understood. Here, we mapped genomic loci occupied by EZH2/H3K27Me3 using chromatin immunoprecipitation followed next-generation sequencing (ChIP-seq) globally profiled EZH2-knockdown cells....
Ultraviolet B (UVB) irradiation has been known to cause skin damage, which is associated with oxidative stress, DNA and apoptosis. Echinacoside a phenylethanoid glycoside isolated from Herba Cistanches, exhibits strong antioxidant activity. In this study, we evaluate the photoprotective effect of echinacoside on UVB-induced damage explore potential molecular mechanism. BALB/c mice HaCaT cells were treated before UVB exposure. Histopathological examination was used damage. Cell viability,...
BACKGROUND:Multi-drug resistance is one of the major problems limiting efficacy cisplatin (CDDP) in treatment hepatocellular carcinoma (HCC), and abnormal microRNA (miRNA) expression drug-resistant cell lines plays an important role liver cancer chemotherapy resistance. MATERIAL AND METHODS:We established stable Hep3B 97L HCC strains resistant to CDDP, both vitro vivo. A combination microarray RT-qPCR experiments were used screen differentially expressed miRNAs strains. CCK-8 assay was...
Sirtuin 6 (SIRT6) is a member of the nicotinamide adenine dinucleotide positivity-dependent class III deacetylase sirtuin family. The present study aimed to explore expression and function SIRT6 in colon cancer. Furthermore, partial mechanism underlying dysregulation was investigated. results immunohistochemistry demonstrated that markedly downregulated cancer tissues, patients with high had better prognosis than those who did not. proliferation apoptotic assays able suppress cell induce...
Inflammatory conditions caused by cancer, chronic diseases or aging can lead to skeletal muscle atrophy. We identified myogenic compounds from Psoralea corylifolia (PC), a medicinal plant that has been used for the treatment of inflammatory and skin diseases. C2C12 mouse myoblasts were differentiated in presence eight isolated PC evaluate their potential. Among them, corylifol A showed strongest transactivation MyoD increased expression markers, such as MyoD, myogenin myosin heavy chain...
Nitric oxide (NO) has an important class of endogenous diatomic molecules that play a key regulatory role in many physiological and biochemical processes. However, the type nitrosamine NO donor stimulated by light advantages compared to conventional donors such as diazeniumdiolates S-nitrosothiols compounds, including easy synthesis, good stability, controllable release. In addition, release can be regulated induction with built-in calibration mechanism fluorescence. Here, we report...
Abstract A series of new modular bifunctional chiral thiourea organocatalysts were synthesized from natural Cinchona alkaloids and amino acids, their performance in the aza‐Henry reaction nitroalkanes to imines, Michael addition acetylacetone nitroolefins acetone was investigated. Under mild conditions, important building blocks β‐nitro amines γ‐nitro carbonyl compounds could be obtained good yields (up 95%) with excellent enantioselectivities 99% ee ) diastereoselectivity 17:1).