A5052688167- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Sirtuins and Resveratrol in Medicine
- Cardiac Structural Anomalies and Repair
- Circadian rhythm and melatonin
- Berberine and alkaloids research
- GDF15 and Related Biomarkers
- Congenital Heart Disease Studies
- Inflammasome and immune disorders
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Macrophage Migration Inhibitory Factor
- Tissue Engineering and Regenerative Medicine
- Autophagy in Disease and Therapy
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- ATP Synthase and ATPases Research
- Pulmonary Hypertension Research and Treatments
- Anatomy and Medical Technology
- MicroRNA in disease regulation
- Circular RNAs in diseases
Xijing Hospital
2016-2025
Air Force Medical University
2016-2025
First Hospital of China Medical University
1987-2015
China Medical University
2015
First Affiliated Hospital of Xi'an Jiaotong University
2012
Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is member the sirtuin that localized primarily to mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has favorable effect in ameliorating MI/R We hypothesized melatonin injury by activating SIRT3 signaling pathway. In this study, mice were pretreated with or without...
Abstract Melatonin confers cardioprotective effect against myocardial ischemia/reperfusion ( MI / R ) injury by reducing oxidative stress. Activation of silent information regulator 1 SIRT 1) signaling also reduces injury. We hypothesize that melatonin may protect activating signaling. This study investigated the protective treatment on heart and elucidated its potential mechanisms. Rats were exposed to in presence or absence receptor antagonist luzindole inhibitor EX 527 then subjected...
Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective cardioprotective agent its strong antioxidative activity. However, roles and underlying mechanisms against MI/R injury in type 1 diabetes (T1D) remain unknown. Since SIRT1 Nrf2 are pivotal regulators mellitus patients suffering from injury, we hypothesized that HKL ameliorates via the SIRT1-Nrf2 signaling pathway....
Hyperglycemia-induced oxidative stress and fibrosis play a crucial role in the development of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), major bioactive metabolite natural antioxidant curcumin, is reported to exert even more effective antioxidative superior antifibrotic properties as well anti-inflammatory antidiabetic abilities. This study was designed investigate potential protective effects THC on experimental DCM its underlying mechanisms, pointing high glucose-induced...
Diabetes mellitus (DM) increases myocardial oxidative stress and endoplasmic reticulum (ER) stress. Melatonin confers cardioprotective effect by suppressing damage. However, the mechanism of melatonin on ischemia-reperfusion (MI/R) injury in type 2 diabetic state are still unknown. In this study, we developed high-fat diet-fed streptozotocin (HFD-STZ) rat, a well-known model, to evaluate MI/R with focus silent information regulator 1 (SIRT1) signaling, stress, PERK/eIF2α/ATF4-mediated ER...
Berberine (BBR) exerts potential protective effect against myocardial ischemia/reperfusion (MI/R) injury. Activation of silent information regulator 1 (SIRT1) signaling attenuates MI/R injury by reducing oxidative damage and inflammation response. This study investigated the antioxidative anti‐inflammatory effects BBR treatment in condition elucidated its mechanisms. Sprague‐Dawley rats were treated with absence or presence SIRT1 inhibitor sirtinol (Stnl) then subjected to conferred...
Abstract Melatonin confers profound protective effect against myocardial ischemia–reperfusion injury ( MI / RI ). Activation of N otch1/ H airy and enhancer split 1 es1) signaling also ameliorates . We hypothesize that melatonin attenuates ‐induced oxidative damage by activating es1 pathway with phosphatase tensin homolog deleted on chromosome 10 P ten)/ A kt acting as the downstream in a membrane receptor‐dependent manner. Male S prague D awley rats were treated (10 mg/kg/day) for 4 wk then...
Sepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units. However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin cleaved product fibronectin type III domain-containing protein 5 (FNDC5) that protects heart from ischemia/reperfusion injury through upregulation mitochondrial ubiquitin ligase (MITOL). Gasdermin D (GSDMD)-dependent pyroptosis plays pivotal role by regulating homeostasis. whether irisin can regulate MITOL to...
Acute myocardial dysfunction in patients with sepsis is attributed to oxidative stress, inflammation, and cardiomyocyte loss; however, specific drugs for its prevention are still lacking. Tetrahydrocurcumin (THC) has been proven contribute the of various cardiovascular diseases by decreasing stress inflammation. This study was performed investigate functions mechanism action THC septic cardiomyopathy.After oral administration (120 mg/kg) 5 consecutive days, a mouse model established via...
Melatonin, a circadian molecule secreted by the pineal gland, confers protective role against cardiac hypertrophy induced hyperthyroidism, chronic hypoxia, and isoproterenol. However, its pressure overload-induced underlying mechanisms remains elusive. In this study, we investigated pharmacological effects of melatonin on pathological transverse aortic constriction (TAC). Male C57BL/6 mice underwent TAC or sham surgery at day 0 were then treated with (20 mg/kg/day, via drinking water) for 4...
Abstract Melatonin functions as an endogenous protective molecule in multiple vascular diseases, whereas its effects on thoracic aortic aneurysm and dissection (TAAD) underlying mechanisms have not been reported. In this study, TAAD mouse model was successfully induced by β‐aminopropionitrile fumarate (BAPN). We found that melatonin treatment remarkably prevented the deterioration of TAAD, evidenced decreased incidence, ameliorated aneurysmal dilation stiffness, improved morphology,...
Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus (DM). However, the mechanisms underlying DCM-induced cardiac injury remain unclear. Recently, role cyclic GMP-AMP synthase/stimulator interferon gene (cGAS/STING) signaling and pyroptosis in DCM has been investigated. Based on our previous results, this study was designed to examine impact irisin, mitochondrial ubiquitin ligase (MITOL/MARCH5), cGAS/STING dysfunction effect gasdermin D (GSDMD)-dependent pyroptosis....
Background Lead-induced tricuspid regurgitation is one of the complications after permanent pacemaker implantation (PPI) and refers to (TR) caused by lead in right ventricle (RV). Objectives To study clinical characteristics severe TR PPI effect transcatheter valve replacement (TTVR) with guidance 3-dimensional (3D) printing. Methods This was a single-center, descriptive study. Six patients were enrolled Xijing Hospital from January 2020 May 2020. Before TTVR, 3D printed (TV) model used for...
Impaired hospitalizations for heart failure (HHF) and mortality are associated with tricuspid regurgitation (TR).
Cardiac dysfunction caused by sepsis is the predominant reason for death in patients with sepsis. However, effective drugs its prevention and molecular mechanisms remain elusive. 1-Deoxynojirimycin (DNJ), a natural iminopyranose, exhibits various biological properties, such as hypoglycemic, antitumor, antiviral, anti-inflammatory activities. whether DNJ can mediate activity resistance sepsis-induced myocardial injury underlying are unclear. Janus kinase signal transducer activator of...
Abstract Background Functional tricuspid regurgitation (FTR) following left‐sided valve surgery (LSVS) is of clinical significance due to its high recurrence and mortality rates. Transcatheter therapy presents a potential solution address this issue. Aims The study aimed assess the safety efficacy transcatheter replacement using Lux‐Valve system in single center for patients with FTR after LSVS. Methods From June 2020 April 2023, 20 symptomatic severe LSVS were referred our center. A...
The impact of aortic arch (AA) morphology on the management procedural details and clinical outcomes transfemoral artery (TF)-transcatheter valve replacement (TAVR) has not been evaluated. goal this study was to evaluate AA patients who had TF-TAVR using an artificial intelligence algorithm then its predictive value for outcomes. A total 1480 consecutive undergoing a new-generation transcatheter heart at 12 institutes were included in retrospective study. measurements evaluated by deep...
Background: Transcatheter aortic valve replacement (TAVR) has been widely used to treat patients with stenosis (AS). The anchoring of most transcatheter heart valves (THV) depends on friction the native (AV). Methods: A total 9 severe AS accepted TAVR using Xcor system transapical access in our center. Clinical outcomes were collected at baseline, before discharge, and 30-day follow-up. Results: All achieved procedural success, postprocedural transesophageal echocardiography showed that all...
Background: Severe pulmonary regurgitation (PR) often occurs after treatment of tetralogy Fallot with a valve ring patch, leading to enlargement and diverse morphological characteristics the native right ventricular outflow tract (nRVOT), which increases difficulty transcatheter replacement (TPVR). The purpose this study was use TPVR simulator help doctors improve their surgical skills by simulating process in vitro. Methods: developed using three-dimensional (3D) printing technology under...
Totally thoracoscopic and beating-heart techniques used in tricuspid valve surgery (TTC-TVS) show favorable outcomes. Transcatheter replacement (TTVR) is an increasingly utilized alternative for patients with regurgitation (TR) at high surgical risk. The purpose of this study was to compare TTVR TTC-TVS examine the outcomes these two different management protocols symptomatic severe TR. A total 116 TR were retrospectively collected divided into (n = 38) 78) groups. primary end points...