A5100684535- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Invertebrate Immune Response Mechanisms
- Stress Responses and Cortisol
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Laser Applications in Dentistry and Medicine
- Renal and related cancers
- Biochemical effects in animals
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
- Corneal Surgery and Treatments
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Photodynamic Therapy Research Studies
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
Shandong University of Traditional Chinese Medicine
2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
First Affiliated Hospital of Henan University
2025
The University of Texas MD Anderson Cancer Center
2025
Nantong University
2015-2024
Affiliated Hospital of Nantong University
2020-2024
Guangzhou Experimental Station
2024
Beijing Obstetrics and Gynecology Hospital
2023
Capital Medical University
2023
Long non-coding RNAs (lncRNAs) have been known to partake in the development and immune escape of hepatocellular carcinoma (HCC). The initial microarray analysis GSE115018 expression profile revealed differentially expressed lncRNA fetal-lethal developmental regulatory RNA (FENDRR) HCC. Therefore, this study's main purpose was explore mechanism tumor suppressor FENDRR regulating HCC cells. Notably, it further validated through study that competitively bound microRNA-423-5p (miR-423-5p),...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Concerns regarding data integrity, which were based a PubPeer thread showing unusually structured flow cytometry plots and an acknowledgements statement that appeared in multiple paper mill papers (https://pubpeer.com/publications/5BDD7EDBC667C3CAD70F57F88FC657), raised by National Science Library Chinese Academy Sciences....
Spin transport is crucial for future spintronic devices operating at bandwidths up to the terahertz (THz) range. In F|N thin-film stacks made of a ferro/ferrimagnetic layer F and normal-metal N, spin mediated by (1) spin-polarized conduction electrons and/or (2) torque between electron spins. To identify cross-over from (2), we study laser-driven currents in F|Pt where consists model materials with different degrees electrical conductivity. For magnetic insulators YIG, GIG maghemite,...
BACKGROUND:Multi-drug resistance is one of the major problems limiting efficacy cisplatin (CDDP) in treatment hepatocellular carcinoma (HCC), and abnormal microRNA (miRNA) expression drug-resistant cell lines plays an important role liver cancer chemotherapy resistance. MATERIAL AND METHODS:We established stable Hep3B 97L HCC strains resistant to CDDP, both vitro vivo. A combination microarray RT-qPCR experiments were used screen differentially expressed miRNAs strains. CCK-8 assay was...
Hepatocellular carcinoma (HCC) accounts for more than 90% of primary liver cancer. Although great progress has been made on HCC molecular mechanism and therapy techniques, the prognosis patient is poor due to high metastasis recurrence.Expression miR-542-3p was quantified by quantitative real-time PCR (qRT-PCR). The role in examined using transwell 3D-culture assay. qRT-PCR, Western blotting luciferase reporter assay were used elucidate mechanisms miR-542-3p-mediated cancer metastasis.In...
Lung adenocarcinoma (LUAD) is one of the most lethal malignancies and currently lacking in effective biomarkers to assist diagnosis therapy. The aim this study investigate hub genes develop a risk signature for predicting prognosis LUAD patients.RNA-sequencing data relevant clinical were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was performed identify associated with mRNA expression-based stemness...
In this study, we looked at the viability of utilizing serum to differentiate between gallbladder (GB) stones and GB polyps using Surface-enhanced Raman spectroscopy (SERS), which has potential be a quick accurate means diagnosing benign diseases. Rapid label-free SERS was used conduct tests on 148 samples, included those from 51 patients with stones, 25 72 healthy persons. We an Ag colloid as spectrum enhancement substrate. addition, employed orthogonal partial least squares discriminant...
Objectives: Ovarian cancer is the most lethal gynecologic malignancy, and targeted therapy for different pathological types molecular phenotypes urgent to be studied. Studies have shown that MicroRNA-592 (miR-592) plays an important negative regulatory role in occurrence of gastrointestinal malignancies, breast cancer, non-small cell lung glioma, but expression miR-592 ovarian mechanism action are still unclear. Methods: The expressions were examined by RT-PCR Western Blot. Cell viability...
Anoikis is a programmed cell death process triggered when cells are dislodged from the extracellular matrix. Numerous long noncoding RNAs (lncRNAs) have been identified as significant factors associated with anoikis resistance in various tumor types, including glioma, breast cancer, and bladder cancer. However, relationship between lncRNAs prognosis of hepatocellular carcinoma (HCC) has received limited research attention. Further needed to investigate this potential link understand role...
The Wnt/β-catenin signaling pathway is critical in kidney development, yet its specific effects on gene expression different embryonic cell types are not fully understood.
Background: Hepatocellular carcinoma (HCC) is among malignancies with the highest fatality toll globally and minimal therapeutic options. Necroptosis a programmed form of necrosis or inflammatory cell death, which can affect prognosis microenvironmental status HCC. Therefore, we aimed to explore prognostic value necroptosis-related lncRNAs (NRLs) in HCC role tumor microenvironment (TME) immunotherapy. Methods: The RNA-sequencing data clinical information were downloaded from Cancer Genome...
Advanced studies demonstrated that hypoxic stress induced KIAA1199 expression leading to enhanced cell migration. is a protein related with cancer metastasis. Hypoxia inducible factor 1α (HIF-1α) transcriptional maintains oxygen homeostasis. Both and HIF-1α were upregulated in many human cancers. In the present study, co-expression of was evaluated for clinicopathological characteristics survival hepatocellular carcinoma (HCC). Clinical-pathological information follow-up data collected from...
GRO β (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little known about expression in gastrointestinal stromal tumors (GIST) or the relationship between clinical attributes of GIST. was examined via immunohistochemical staining 173 GIST samples using tissue microarray. The relevant patient characteristics assessed, chi-square tests. Univariate multivariate analysis carried out Cox regression method. High cytoplasm...
The development of hepatocellular carcinoma (HCC) is a complex pathological process. Long intergenic non-protein-coding RNA 1667 (LINC01667, also known as MGC38584) plays an oncogenic role in several human cancers; however, its functional HCC tumorigenesis remains unknown. Here, we first evaluated the gene expression levels LINC01667 using data from Cancer Genome Atlas and Gene Expression Profiling Interactive Analysis (GEPIA) databases. We then elucidated association between survival rates...
Objective: To identify new prognostic markers and therapeutic targets for gastric adenocarcinoma. Methods: The public datasets of adenocarcinoma collected from GEO database (GSE33335 GSE63089) were downloaded analysis. There 70 GC tissues paired normal in the two profile datasets. Differentially expressed genes (DEGs) between stomach selected by R software. Protein-protein interaction (PPI) these DEGs visualized Search Tool Retrieval Interacting Genes (STRING). key gene sets analyzed...
Abstract Background Tumor angiogenesis is an important factor in inducing tumor recurrence, metastasis and drug resistance, which directly affects the therapeutic effect of patients. As a key treatment for liver cancer, TACE can prolong survival time some patients, but patients with cancer after TACE, relationship between resistance angiogenesis, microenvironment, hot cold tumors immunotherapy not clear. Methods We systematically evaluated 36 angiogenesis-related genes (ARGs) comprehensively...
Abstract Anoikis is a term used to describe the programmed cell death that takes place when cells become disconnected from extracellular matrix[1]. Numerous long non-coding RNAs (lncRNAs) have been found be linked anoikis resistance in various tumors, including glioma[2], breast cancer[3], and bladder cancer[4]. There lack of studies examining relationship between ARLs HCC prognosis. Further research needed explore this potential link understand role progression. Patients methods: In study,...