A5100427110- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- MRI in cancer diagnosis
- RNA Research and Splicing
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Inflammatory Bowel Disease
- interferon and immune responses
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Heat shock proteins research
- Immune cells in cancer
- Advanced MRI Techniques and Applications
- COVID-19 diagnosis using AI
Union Hospital
2022-2025
Fujian Medical University
2022-2025
Guizhou University
2025
Second Affiliated Hospital of Zhejiang University
2024
Affiliated Hospital of Nantong University
2022-2024
Nantong University
2020-2024
Shanghai Stomatological Hospital
2024
Fudan University
2015-2024
Fudan University Shanghai Cancer Center
2023
Hangzhou First People's Hospital
2023
Tamoxifen resistance remains a clinical challenge for hormone receptor-positive breast cancer. Recently, dysregulations in autophagy have been suggested as potential mechanism tamoxifen resistance. Although the long noncoding RNA H19 is involved various stages of tumorigenesis, its role unknown. Here, we assessed development tamoxifen-resistant Quantitative real-time PCR analyzed expression cancer tissues. Knockdown was used to assess sensitivity vitro and vivo. Both knockdown overexpression...
Importance Type 2 diabetes (T2D) is associated with the progression of cognitive dysfunction. Physical activity benefits cognition, but no evidence from randomized clinical trials has shown whether tai chi chuan better long-term than fitness walking in function for patients T2D and mild impairment (MCI). Objective To compare effectiveness chuan, a mind-body exercise, improving older adults MCI, walking. Design, Setting, Participants This trial was conducted between June 1, 2020, February 28,...
Abstract Among patients with a preoperative positive axillary ultrasound, around 40% of them are pathologically proved to be free from lymph node (ALN) metastasis. We aimed develop and validate model predict the probability ALN metastasis as tool support clinical decision-making. Clinicopathological features 322 early breast cancer ultrasound findings were analyzed. Multivariate logistic regression analysis was performed identify independent predictors A created analysis, comprising...
Ferroptosis, which is characterized by the accumulation of intracellular iron and subsequent lipid peroxidation, a newly discovered form regulated cell death plays an important role in tumor suppression. Herein, we showed that Polyphyllin III, major saponin extracted from Paris polyphylla rhizomes, exerted its proliferation-inhibitory effect on MDA-MB-231 triple-negative breast cancer cells mainly through ACSL4-mediated peroxidation elevation ferroptosis induction. ACSL4 deletion partly...
Abstract Physical exercise protects against cognitive impairment caused by chronic cerebral hypoperfusion (CCH). However, the mechanisms through which sends signals from periphery to central nervous system remain incompletely understood. This study demonstrated that promotes secretion of muscle‐derived small extracellular vesicles (sEVs), facilitate interorgan communication between muscle and brain. Systematic delivery sEVs enhances synaptic plasticity alleviated in CCH. Notably, miRNA...
Challenges drive the state-of-the-art of automated medical image analysis. The quantity public training data that they provide can limit performance their solutions. Public access to methodology for these solutions remains absent. This study implements Type Three (T3) challenge format, which allows on private and guarantees reusable methodologies. With T3, organizers train a codebase provided by participants sequestered data. T3 was implemented in STOIC2021 challenge, with goal predicting...
Non‑small cell lung cancer (NSCLC) is a leading subtype of cancer, with high mortality rates. Recently, long non‑coding RNAs (lncRNAs) have been associated NSCLC. The present study aimed to examine the role TP73 antisense RNA 1 (TP73‑AS1) lncRNA in TP73‑AS1 and microRNA(miR)‑34a‑5p expression levels were measured using reverse transcription‑quantitative PCR (RT‑qPCR) chromogenic situ hybridization (CISH). Cell proliferation, apoptosis, migration invasion was determined Counting Kit‑8...
Aims: The study aimed to conduct a meta-analysis determine the abnormalities of white matter in patients with type 2 diabetes mellitus (T2DM) by identifying consistency diffusion tensor imaging (DTI). Method: literature for DTI comparing T2DM controls published before October 30, 2020, were reviewed PubMed, Web Science, Embase, CNKI, and Wan Fang databases. was performed using activation likelihood estimation (ALE) method, including 12 reports 381 T2DM. Results: identified 10 regions that...
Diabetic foot ulcer (DFU) is a serious diabetes complication, significantly impacting the quality of life, particularly in elderly. Age-associated DFUs pose additional challenges due to impaired healing mechanisms. Our study aims explore role metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) as miR-142 sponge repairing diabetic rat tissue under age-associated diabetes, offering new theoretical basis and therapeutic target for preventing treating vascular disease
In recent decades, the stromal cell-derived factor-l (SDF-1) and Gab1 have been investigated to be involved in oncogenesis. However, it is scarcely reported that SDF-1-Gab1 pathway mediates proliferation apoptosis human chondrosarcoma (CS). this study, we assessed expression of 90 CS solid tumors by immunohistochemistry, immunoblotting, qRT-PCR, then, some vitro assays were also applied cells treated with SDF-1. We observed overexpression was positively correlated lung metastasis recurrence,...
Abstract Background Gastric cancer (GC) is among the most malignant tumors, yet pathogenesis not fully understood, especially lack of detailed information about mechanisms underlying long non‐coding RNA (lncRNA)‐mediated post‐translational modifications. Here, molecular and clinical significance novel lncRNA syndecan‐binding protein 2‐antisense 1 (SDCBP2‐AS1) in tumorigenesis progression GC were investigated. Methods The expression levels SDCBP2‐AS1 132 pairs adjacent normal tissues...
Diabetic retinopathy (DR) is one of the most common eye conditions among diabetic patients. However, vision loss occurs primarily in late stages DR, and symptoms visual impairment, ranging from mild to severe, can vary greatly, adding burden diagnosis treatment clinical practice. Deep learning methods based on retinal images have achieved remarkable success automatic DR grading, but them neglect that presence diabetes usually affects both eyes, ophthalmologists compare eyes concurrently for...
Compelling evidence has demonstrated that Th17 cells play an essential role in the pathogenesis of multiple sclerosis (MS). Long noncoding RNAs (lncRNAs) have been confirmed as vital regulators immune cell differentiation and other functions. However, whether how lncRNAs influence functional behaviors remain largely unclear. Here, we identified a lncRNA, namely Gm15575, is specifically enriched spleen tissues EAE mice. Functionally, knockdown Gm15575 suppressed secretion IL17A....
Aim: The aim of this study was to evaluate and compare the 24-month follow-up results intravitreal conbercept with ranibizumab in treatment choroidal neovascularization (CNV), secondary pathological myopia (PM). Methods: Fifty-nine patients' 64 eyes myopic CNV were retrospectively reviewed. Thirty-one underwent (group C) 33 R), respectively. No patients have received any before. main outcome best-corrected visual acuity (BCVA) uses an international standard chart is converted minimum...
To assess the predictive value of an ultrasound-based radiomics-clinical nomogram for grading residual cancer burden (RCB) in breast patients.