A5070510691- RNA modifications and cancer
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Plant and Fungal Species Descriptions
- Plant Parasitism and Resistance
- Animal Disease Management and Epidemiology
- Plant Diversity and Evolution
- Viral Infections and Immunology Research
- Plant Stress Responses and Tolerance
- RNA and protein synthesis mechanisms
- Plant-Microbe Interactions and Immunity
- Hippo pathway signaling and YAP/TAZ
- Plant Reproductive Biology
- Plant Virus Research Studies
- Immune cells in cancer
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
- Animal Virus Infections Studies
- Plant Gene Expression Analysis
- CRISPR and Genetic Engineering
- Bioenergy crop production and management
- Natural Compounds in Disease Treatment
Wuhan University
2018-2024
Guizhou University
2021-2024
Zhejiang University
2015-2023
Sir Run Run Shaw Hospital
2019-2023
Shanghai Jiao Tong University
2022-2023
Blood Center of Zhejiang Province
2019-2022
Third Xiangya Hospital
2013-2021
Central South University
2013-2021
Northwest A&F University
2016-2019
South China University of Technology
2015
Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation lipid peroxidation and involved in various pathophysiological conditions, including cancer. Targeting ferroptosis considered to be novel anti-cancer strategy. The identification FDA-approved drugs as inducers proposed new promising approach for cancer treatment. Despite growing body evidence indicating potential efficacy anti-diabetic metformin an agent, exact mechanism underlying...
Tamoxifen resistance remains a clinical challenge for hormone receptor-positive breast cancer. Recently, dysregulations in autophagy have been suggested as potential mechanism tamoxifen resistance. Although the long noncoding RNA H19 is involved various stages of tumorigenesis, its role unknown. Here, we assessed development tamoxifen-resistant Quantitative real-time PCR analyzed expression cancer tissues. Knockdown was used to assess sensitivity vitro and vivo. Both knockdown overexpression...
// Ling Ding 1 , Guikai Liang Zhangting Yao Jieqiong Zhang Ruiyang Liu Huihui Chen Yulu Zhou Honghai Wu Bo Yang Qiaojun He Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute Pharmacology and Toxicology, College Pharmaceutical Sciences, University, Hangzhou 310058, China Correspondence to: He, e-mail: qiaojunhe@zju.edu.cn Keywords: metformin, macrophage polarization, cancer metastasis, AMPKα1 Received: July 05, 2015 Accepted: October...
Autophagy is a conserved intracellular degradation system that plays dual role in cell death; thus, therapies targeting autophagy cancer are somewhat controversial. Ferroptosis new form of regulated death featured with the iron-dependent accumulation lethal lipid ROS. This pathway morphologically, biochemically and genetically distinct from other forms death. Accumulating studies have revealed crosstalk between ferroptosis at molecular level. In this review, we summarize mechanisms...
Autophagy and ferroptosis have been major foci of biomedical research in recent years. Elucidation their intrinsic molecular relationships is important for cancer prevention treatment. Metformin can directly inhibit tumorigenesis, although the mechanism responsible this not fully understood. Here, we demonstrate that metformin lncRNA‐H19 regulate both autophagy ferroptosis. inducers H19 reverse production lipid reactive oxygen species inhibition induced by metformin. The present study...
Abstract Ferroptosis, which is characterized by intracellular iron accumulation and lipid peroxidation, a newly described form of regulated cell death that may play key role in tumour suppression. In the present study, we investigated expression profiles biological effects fascin actin-bundling protein 1 (Fascin, gene name FSCN1 ) breast cancer. addition, bioinformatics analysis TCGA cancer database gain- loss-of-function studies showed Fascin enhances sensitivity to erastin-induced...
Ferroptosis, which is characterized by the accumulation of intracellular iron and subsequent lipid peroxidation, a newly discovered form regulated cell death plays an important role in tumor suppression. Herein, we showed that Polyphyllin III, major saponin extracted from Paris polyphylla rhizomes, exerted its proliferation-inhibitory effect on MDA-MB-231 triple-negative breast cancer cells mainly through ACSL4-mediated peroxidation elevation ferroptosis induction. ACSL4 deletion partly...
Abstract Sorafenib is a multikinase inhibitor used as first-line treatment for advanced hepatocellular carcinoma (HCC), but it has shown modest to low response rates. The characteristic tumour hypoxia of HCC maybe major factor underlying hypoxia-mediated failure. Thus, urgent elucidate the mechanisms sorafenib resistance in HCC. In this study, we found that induced nuclear translocation Yes associate-Protein (YAP) and subsequent transactivation target genes promote cell survival escape...
Tumor-associated macrophages (TAMs) has been regarded as the most prominent component in tumor microenvironment. The correlation between TAM density and poor prognosis Hepatocellular carcinoma (HCC) patients suggests a supportive role for TAMs progression. Here we employed co-culture system to interrogate molecular link Yes-Associated Protein (YAP) chemotaxis HCC cells. We found that YAP activation was critical recruitment of towards Furthermore, cytokine array quantitative RT-PCR analyses...
Mounting an efficient defense against pathogens requires RNA binding proteins (RBPs) to regulate immune mRNAs transcription, splicing, export, translation, storage, and degradation. RBPs often have multiple family members, raising the question of how they coordinate carry out diverse cellular functions. In this study, we demonstrate that EVOLUTIONARILY CONSERVED C-TERMINAL REGION 9 (ECT9), a member YTH protein in Arabidopsis, can condensate with its homolog ECT1 control responses. Among 13...
A 5′-leader, known initially as the 5′-untranslated region, contains multiple isoforms due to alternative splicings (aS) and transcription start sites (aTSS). Therefore, a representative 5′-leader is demanded examine embedded RNA regulatory elements in controlling translation efficiency. Here, we develop ranking algorithm deep-learning model annotate 5′-leaders for five plant species. We rank intra- inter-sample frequency of aS-mediated transcript using Kruskal-Wallis test-based identify...
Caragana korshinskii is commonly employed to improve drought ecosystems on the Loess Plateau, although molecular mechanism at work poorly understood, particularly in terms of plant's ability tolerate stress. Water most severe limiting factor for plant growth Plateau. The trichome known play an efficient role reducing water loss through decreasing rate transpiration, so this study, we focused trichome-related gene expression ecological adaptation C. under low precipitation conditions. In...
Abstract Upstream open reading frames (uORFs) are prevalent in eukaryotic mRNAs. They act as a translational control element for precisely tuning the expression of downstream major frame (mORF). uORF variation has been clearly associated with several human diseases. In contrast, natural variants plants have not ever identified or linked any phenotypic changes. The paucity such evidence encouraged us to generate this database-uORFlight (http://uorflight.whu.edu.cn). It facilitates exploration...
Chemoresistance is a daunting challenge to the prognosis of patients with breast cancer. Signal transducer and activator transcription (STAT) 5a plays vital roles in development various cancers, but its function cancer controversial, role chemoresistance remains unexplored. Here we identified STAT5a as inducer that regulates expression ABCB1 can be targeted by pimozide, an FDA-approved psychotropic drug. First, found were expressed at higher levels doxorubicin-resistant cell lines...
Oreocharis leveilleana Fedde was collected in Ta-pin 1910 and published 1911. The location verified within western Luodian County, Guizhou Province, China. However, there have been no records of the species’ collection for more than 100 years since then. After extensive investigations by our research team on type locality its surrounding areas, we found that it is widely distributed County eastern Wangmo During further original literature, specimens O. , taxonomic position which once treated...