A5022822921- Genomics and Phylogenetic Studies
- Research in Cotton Cultivation
- Plant Molecular Biology Research
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Heat shock proteins research
- Plant Virus Research Studies
- RNA Research and Splicing
- Antimicrobial Peptides and Activities
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Biofuel production and bioconversion
- Genetics, Bioinformatics, and Biomedical Research
- Chromosomal and Genetic Variations
- Light effects on plants
- Transgenic Plants and Applications
- Plant and Fungal Interactions Research
- Plant responses to water stress
- vaccines and immunoinformatics approaches
- Gene expression and cancer classification
- Plant nutrient uptake and metabolism
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Fern and Epiphyte Biology
Wuhan University
2023-2025
Shenzhen Genoimmune Medical Institute
2019
Huazhong Agricultural University
2016-2017
Summary Jasmonic acid ( JA ) signaling has been well studied in Arabidopsis. Most reports focus on the role of biological pathways, such as stress resistance, trichome initiation and anthocyanin accumulation. The JASMONATE ZIM ‐ DOMAIN JAZ protein is one important repressors pathway. Previous studies showed that functions fiber elongation, but little known about how genes function development. In this study, a cotton (Gh 2) containing highly conserved TIFY motif C‐terminal Jas domain was...
Abstract Cancer is a major cause of death worldwide, and an early diagnosis required for favorable prognosis. Histological examination the gold standard cancer identification; however, large amount inter-observer variability exists in histological diagnosis. Numerous studies have shown genesis accompanied by accumulation harmful mutations, potentiating identification based on genomic information. We proposed method, GDL (genome deep learning), to study relationship between variations traits...
Epigenetic modifications are highlighted for their great importance in regulating plant development, but function associated with single-cell differentiation remains undetermined. Here, we used the cotton fibre, which is epidermal hair on ovule, as a model to investigate regulatory role of DNA methylation cell differentiation. The level CHH (H = A, T, or C) was found increase during fibre accompanied by decrease RNA-directed (RdDM). Examination nucleosome positioning revealed gradual...
Cotton fibre is an important natural for the textile industry. The number of initials determines lint percentage, which factor cotton yield. Although development has been described by transcriptomic analysis, mechanism long noncoding RNA manipulates initiation and fuzz fibres remains unknown. In this study, three lines with different percentages were developed crossing Xu142 its fibreless mutant fl. We collected epidermal cells from ovules attached at 0 5 days post anthesis (DPA) Xu142, fl...
A 5′-leader, known initially as the 5′-untranslated region, contains multiple isoforms due to alternative splicings (aS) and transcription start sites (aTSS). Therefore, a representative 5′-leader is demanded examine embedded RNA regulatory elements in controlling translation efficiency. Here, we develop ranking algorithm deep-learning model annotate 5′-leaders for five plant species. We rank intra- inter-sample frequency of aS-mediated transcript using Kruskal-Wallis test-based identify...
Effective modulation of gene expression in plants is achievable through tools like CRISPR and RNA interference, yet methods for directly modifying endogenous proteins remain lacking. Here, we identify the E3 ubiquitin ligase E3TCD1 develope a Targeted Condensation-prone-protein Degradation (TCD) strategy. The X-E3TCD1 fusion protein acts as genetically engineered degrader, selectively targeting prone to condensation. For example, transgenic with Teosinte branched 1 (TB1) degrades native TB1...
Abstract Motivation Cancer is a major cause of death worldwide, and an early diagnosis required for favorable prognosis. Histological examination the gold standard cancer identification; however, there large amount inter-observer variability in histological diagnosis. Numerous studies have shown that genesis accompanied by accumulation harmful mutations within patients’ genome, potentiating identification based on genomic information. We proposed method, GDL (genome deep learning), to study...
Abstract Background Accurate prediction of epitopes presented by human leukocyte antigen (HLA) is crucial for personalized cancer immunotherapies targeting T cell epitopes. Mass spectrometry (MS) profiling eluted HLA ligands, which provides high-throughput measurements associated peptides in vivo , can be used to faithfully model the presentation on surface. In addition, gene expression profiles measured RNA-seq data a specific cell/tissue type significantly improve performance epitope...
Abstract Ethylene-triggered flowering is a common phenomenon in plants of the family Bromeliaceae, but its molecular mechanism remains unclear. As classical group small RNAs, microRNAs play an essential role regulation flowering. In this study, we found that various miRNAs participate ethylene-triggered process Aechmea fasciata via RNA sequencing using juvenile and adult treated with ethylene for 24 hours. Finally, 63 known miRNAs, 52 novel 1721 target genes were identified or predicted....
Abstract Effective methods, such as CRISPR and RNA interference, exist for modulating gene expression at DNA levels, but approaches directly modifying endogenous proteins remain lacking in plants. Here, we develop a targeted condensation-prone-protein degradation (TCD) strategy to eliminate proteins, particularly those prone condensation. We identify an E3 ligase, E3TCD1, that degrades itself selectively targets other when fused them. In rice, transgenic E3TCD1 fusions with Teosinte branched...