A5101625662- Head and Neck Cancer Studies
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Hair Growth and Disorders
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Oral Health Pathology and Treatment
- Respiratory viral infections research
- RNA modifications and cancer
- Wound Healing and Treatments
- Skin Protection and Aging
- Distributed Sensor Networks and Detection Algorithms
- Organophosphorus compounds synthesis
- Phosphorus compounds and reactions
- Extracellular vesicles in disease
- Advanced Biosensing Techniques and Applications
- Retinoids in leukemia and cellular processes
- Drug Transport and Resistance Mechanisms
- Tissue Engineering and Regenerative Medicine
- RNA Research and Splicing
Peking University
2021-2022
The People's Hospital of Guangxi Zhuang Autonomous Region
2014-2021
Beijing University of Chinese Medicine
2019-2021
Jilin University
2019-2021
Beijing National Laboratory for Molecular Sciences
2021
BGI Group (China)
2019
Shenzhen Genoimmune Medical Institute
2019
Tianjin Chest Hospital
2011
Flinders University
2009
Air Force Medical University
2006
Abstract Background Skin wounding is very common and may be slow to heal. Increasing evidence shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance skin wound healing in a paracrine manner. However, the mechanism underlying this phenomenon has not yet been elucidated. Thus, objective of present study was identify signaling pathways factors by which MSC-derived promote de novo tissue regeneration response healing. Methods In vitro vivo models were created...
PBX homeobox 1 (PBX1) is involved in the maintenance of pluripotency human embryonic and hematopoietic stem cells; however, effects PBX1 self-renewal reprogramming hair follicle mesenchymal cells (HF-MSCs) are unclear. The AKT/glycogen synthase kinase (GSK) 3β pathway regulates cell metabolism, proliferation, apoptosis, reprogramming, p16 p21, which act downstream this pathway, regulate cycle, apoptosis induced by reprogramming. Here, we aimed to elucidate roles regulating proliferation...
Stem cells derived from elderly donors or harvested by repeated subculture exhibit a marked decrease in proliferative capacity and multipotency, which not only compromises their therapeutic potential but also raises safety concerns for regenerative medicine. NANOG—a well-known core transcription factor—plays an important role maintaining the self-renewal pluripotency of stem cells. Unfortunately, mechanism that NANOG delays mesenchymal cell (MSC) senescence is until now. In our study, we...
Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate characteristics in different kinds cancer. But links between circulating and nasopharyngeal were still lacking. Therefore, we explored cells' distribution their possible associations carcinoma.Firstly, found that positive ratio extremely high four stages carcinoma. Meanwhile, ratios mesenchymal higher early Apart from epithelial cells, total,...
Tissues and organs undergo structural deterioration functional decline during aging. DNA damage is considered a major cause of stem cell senescence. Although cells develop sophisticated repair systems, when the intrinsic extrinsic insults exceed capacity, cellular senescence, age-related diseases inevitably occur. Therefore, prevention alleviation an alternative to in attenuating senescence preventing diseases. Pre-B-cell leukaemia homeobox 1 (PBX1) participates maintaining pluripotency...
Topiroxostat is a selective xanthine oxidoreductase (XOR) inhibitor for the management of hyperuricemia in patients with or without gout. In this work, we aim to employ physiologically based pharmacokinetic (PBPK) model drug-target residence time predict and characterize both pharmacokinetics (PK) pharmacodynamics (PD) topiroxostat humans. The plasma concentration-time profile was simulated on drug properties human physiology parameters. predictive power PBPK then demonstrated by comparison...
Screening functional food ingredients (FFI) from medicinal and edible plants (MEP) has still remained a great challenge due to the complexity of MEP its obscure function mechanisms. Herein, an integrated strategy based on sequential metabolites identification approach, network pharmacology, molecular docking, surface plasmon resonance (SPR) analysis was proposed for quickly identifying active constituents in MEP. First, biotransformation process MEP, including intestinal absorption...
This study aims to explore the feasibility of narrow-band imaging (NBI) applied for diagnostic screening a high-risk population nasopharyngeal carcinoma (NPC) and increase accuracy rate biopsy diagnosis early-stage patients. The positive NPC EB virus antibody was followed up. At same time, serological pharyngorhinoscopy were carried out. specific methods as follows: (1) all subjects received examinations through both HD endoscopic white light mode (WL) NBI mode, (2) conducted on with...
Abstract Introduction: This study was undertaken to determine the outcomes of patients treated for squamous cell carcinoma (SCC) oesophagus. Methods: The group consisted 61 (median age: 64 years) with invasive SCC oesophagus who underwent resection between 1987 and 2007 in Adelaide, South Australia. Thirty‐two (52%) were female. Survival data available all patients. log rank test performed identify prognostic factors survival. Results: 5‐year overall survival rate 33% (median: 24 months). Of...
Cholestasis is the most destructive pathological manifestation of liver disease and available treatments are very limited. Paeoniae Radix Rubra (PRR) an important traditional Chinese drug used to treat cholestasis. This study combined targeted metabonomics, PCR array analysis, 16S rRNA sequencing analysis further clarify mechanisms PRR in treatment conspicuously reversed elevation fatty acids (FFA 14:0 other 14 acids) decrease organic (pyruvic acid citric acid) a cholestatic model induced by...
Simotang oral liquid (SMT), a well-known traditional Chinese medicine formula composed of four medicinal and edible plants, has been extensively used for treating gastrointestinal disorders (GIDs) since ancient times. However, the major active constituents underlying molecular mechanism SMT on GIDs are still partially understood. Herein, preliminary chemical profile was first identified by ultrahigh-pressure chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry...
Most algorithms for the multi-armed bandit problem in reinforcement learning aimed to maximize expected reward, which are thus useful searching optimized candidate with highest reward (function value) diverse applications (e.g., AlphaGo). However, some typical application scenaios such as drug discovery, aim is search a set of candidates high reward. Here we propose reversible upper confidence bound (rUCB) algorithm purpose, and demonstrate its virtual screening upon intrinsically disordered...
The aim of this study is investigate the influence endoscopic sinus surgery on quality life and prognosis patients with early nasopharyngeal carcinoma. Patients initially diagnosed carcinoma received surgical treatment were matched who chemoradiotherapy at a ratio 1:1, according to following seven factors: gender, age, T staging, N clinical radiotherapy options, chemotherapy options. in group plus chemoradiotherapy, while subjects control chemoradiotherapy. before after was evaluated based...
Abstract Background Accurate prediction of epitopes presented by human leukocyte antigen (HLA) is crucial for personalized cancer immunotherapies targeting T cell epitopes. Mass spectrometry (MS) profiling eluted HLA ligands, which provides high-throughput measurements associated peptides in vivo , can be used to faithfully model the presentation on surface. In addition, gene expression profiles measured RNA-seq data a specific cell/tissue type significantly improve performance epitope...
Our previous studies showed that ZBTB7A played an important role in promoting nasopharyngeal carcinoma (NPC) progression. However, molecular mechanisms of different levels are still unclear. It is necessary to search markers which closely connected with ZBTB7A. We selected NPC sublines CNE2 stably transfecting empty plasmid (negative control, NC) and short hair RNA (shRNA) targeting as research objectives. Microarray was used screen differentially expressed long noncoding RNAs (lncRNAs)...
With the growing prominence of Mixture Experts (MoE) architecture in developing large-scale foundation models, we investigate Hierarchical (HMoE), a specialized variant MoE that excels handling complex inputs and improving performance on targeted tasks. Our investigation highlights advantages using varied gating functions, moving beyond softmax within HMoE frameworks. We theoretically demonstrate applying tailored functions to each expert group allows achieve robust results, even when...
To evaluate the efficacies of different treatments for recurrent cervical lymph nodes and factors contributing to prognosis in patients with nasopharyngeal carcinoma after radiotherapy.Clinical data 79 radiotherapy were retrospectively analyzed, all cases diagnosed as having by pathological examination. The including sex, age, interval between completion recurrence, rN stage, treatment methods, location relationship lesion primary tumor neck analyzed prognosis. Kaplan-Meier curves, Log-rank...