A5102802295- Congenital Heart Disease Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Diabetes and associated disorders
- Traditional Chinese Medicine Studies
- Congenital Anomalies and Fetal Surgery
- Phytochemistry and Bioactivity Studies
- Sarcoma Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Pregnancy-related medical research
- Lung Cancer Research Studies
- Geotechnical Engineering and Underground Structures
- ZnO doping and properties
- Coronary Artery Anomalies
- Spine and Intervertebral Disc Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
- Musculoskeletal pain and rehabilitation
- Pelvic floor disorders treatments
Fujian Medical University
2025
Shenzhen Second People's Hospital
2025
Zhangzhou Municipal Hospital of Fujian Province
2025
Guangxi University
2025
Lanzhou University
2012-2024
Lanzhou University Second Hospital
2012-2024
Shanghai Jiao Tong University
2024
Southeast University
2024
State Key Laboratory of Digital Medical Engineering
2024
Zhejiang Ocean University
2024
Recent research indicates that the intestinal microbial community, known as gut microbiota, may play a crucial role in pathogenesis of nonalcoholic fatty liver disease (NAFLD). To understand this relationship, study used comprehensive bibliometric analysis to explore and analyze currently little-known connection between microbiota NAFLD, well new findings possible future pathways field. provide an in-depth current focus issues developments on interaction NAFLD. In study, all data were...
Introduction Type 2 diabetes (T2D) is a complex metabolic disorder with significant global health implications. Understanding the molecular mechanisms underlying T2D crucial for developing effective therapeutic strategies. This study employs single-cell RNA sequencing (scRNA-seq) and machine learning to explore pathogenesis of T2D, particular focus on immune cell infiltration. Methods We analyzed scRNA-seq data from islet cells nondiabetic (ND) patients, identifying differentially expressed...
Islet transplantation has now become a promising treatment for insulin-deficient diabetes mellitus. Compared to traditional treatments, cell therapy can restore endogenous insulin supplementation, but its large-scale clinical application is impeded by donor shortages, immune rejection, and unsuitable sites. To overcome these challenges, an increasing number of studies have attempted transplant hydrogel-encapsulated islet cells treat diabetes. This review mainly focuses on the strategy...
A number of recent studies have suggested that icariin (ICA), a class phytochemical with numerous biological activities, may exert protective effects against postmenopausal bone loss. However, it remains unclear whether ICA regulates or improves the osteoblastic function marrow stromal cells (BMSCs) in treatment and prevention osteoporosis. In present study, osteogenic differentiation BMSCs from ovariectomy (OVX) rats was found to be significantly decreased vitro compared had undergone sham...
Intervertebral disc degeneration (IVDD) is a main cause of low back pain that associated with extracellular matrix (ECM) degradation and inflammation. This study aims to investigate the role DNMT3B its regulatory mechanisms in IVDD. IVDD rat models were constructed followed by transfections oe-DNMT3B or oe-YAP order explore development After transfection, nucleus pulposus (NP) cells isolated transfected oe-DNMT3B, oe-TRPA1, si-YAP, oe-COX2 functions NP cells. was poorly expressed tissues...
Recently, the pre-treatment platelet-lymphocyte ratio (PLR), which is based on blood parameters, was accepted as a prognostic factor for patients with various cancers. Numerous studies have investigated role of PLR in pancreatic cancer; however, it remains unclear. Therefore, we conducted this meta-analysis to evaluate relationship between and overall survival (OS) cancer.We performed systematic literature search PubMed, Embase Web Science databases relevant that explored cancer. The hazard...
Topiroxostat is a selective xanthine oxidoreductase (XOR) inhibitor for the management of hyperuricemia in patients with or without gout. In this work, we aim to employ physiologically based pharmacokinetic (PBPK) model drug-target residence time predict and characterize both pharmacokinetics (PK) pharmacodynamics (PD) topiroxostat humans. The plasma concentration-time profile was simulated on drug properties human physiology parameters. predictive power PBPK then demonstrated by comparison...
The macrophages are involved in all stages of cardiovascular diseases, demonstrating the correlation between inflammation, atherosclerosis, and myocardial infarction (MI). Here, we aim to investigate macrophages-related genes deterioration atherosclerosis.GSE41571 was downloaded abundance immune cells estimated by utilizing xCell. By limma test analysis, differentially expressed (DEMRGs) were documented. functional pathways protein-protein interaction (PPI) network analyzed hub DEMRGs...
Background Previous research has posited a potential correlation between the gut microbiota and onset of appendicitis; however, precise causal connection appendicitis remains an unresolved contentious issue. Methods In this investigation, we performed Mendelian randomization (MR) analysis employing publicly accessible summary data extracted from genome-wide association studies (GWAS) to elucidate nexus development appendicitis. We initially identified instrumental variables (IVs) through...
It is known that miRNAs play various roles in malignant tumors. This study designed to investigate whether miR-125b levels can be used predict the clinical response of patients with osteosarcoma (OS) cisplatin-based chemotherapy.From January 2010 July 2015, 82 resectable OS and 56 unresectable were enrolled. Blood samples collected quantitative real-time PCR was applied determine expression. Clinical data through medical records, treated according National Comprehensive Cancer Network...
Myocardial infarction (MI) stands as the predominant cause of morbidity and mortality within spectrum cardiovascular diseases, with an unfavorable long-term prognosis. Vagus nerve stimulation (VNS) emerges a potential clinically significant intervention for alleviating myocardial remodeling after MI, offering promise therapeutic approach. However, challenges persist in addressing fundamental issues flexibility, miniaturization, use VNS devices. Here, we devised implantable ultrasound-driven...
Abstract Intercostal artery aneurysms associated with coarctation of aorta (CoA) are rare and their natural histories poorly understood. This report describes the surgical correction this anomaly in an adult without performing extracorporeal circulation. The coarctated segment intercostal aneurysm were resected, continuity descending was reestablished interposed vascular graft. (J Card Surg 2010;25:719-720)