A5102208935- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- TGF-β signaling in diseases
- Gallbladder and Bile Duct Disorders
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Angiogenesis and VEGF in Cancer
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Diverticular Disease and Complications
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- PI3K/AKT/mTOR signaling in cancer
Nanchang University
2015-2024
Second Affiliated Hospital of Nanchang University
2015-2024
Jiangxi Provincial Cancer Hospital
2014
The University of Adelaide
2013
SleepMed
2013
Jiangxi Chest Hospital
2012
Okayama University
1999-2002
Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs heterogeneous, with distinct phenotypes influenced by microenvironment surrounding tumor tissues, but relatively little is known about key molecular in these cells that contribute to malignant phenotypes. Autophagic activity a critical factor development contributes enhancing cellular fitness and survival hostile microenvironment. However, basis relations between autophagy polarization remain...
Abstract Background Macrophages, the key component of tumor microenvironment, are differentiated mononuclear phagocyte lineage cells that characterized by specific phenotypic characteristics have been implicated in growth, angiogenesis, and invasion. CX3CR1, chemoattractant cytokine CX3CL1 receptor, plays an important role modulating inflammatory responses, including monocyte homeostasis macrophage phenotype function. However, CX3CR1 regulation microenvironment is not fully understood....
Abstract The ubiquitin-like protein FAT10 and the homeobox HOXB9 each promote metastatic progression in hepatocellular carcinoma (HCC). In this study, we investigated clinicopathologic significance of HCC a mechanistic role for HOXB9-mediated invasiveness metastasis. Relative to adjacent normal tissues, were markedly overexpressed HCC, where positive correlation their expression associated malignant characteristics found. RNAi-mediated silencing decreased inhibited invasion metastasis vitro...
Abstract Human HLA-F adjacent transcript 10 (FAT10) is the only ubiquitin-like protein that can directly target substrates for degradation by proteasomes, but it also stabilize expression of certain antagonizing ubiquitination, through mechanisms as yet uncharacterized. In this study, we show how FAT10 stabilizes translation elongation factor eEF1A1, which contributes to cancer cell proliferation. overexpression increased was sufficient promote proliferation cells. Mechanistic investigations...
Abstract Negative regulator of ubiquitin-like protein 1 (NUB1), an inhibitor neural precursor cells expressed developmentally downregulated 8 (NEDD8), is implicated in tumor growth. However, the expression NUB1 hepatocellular carcinoma (HCC) and its effects on HCC growth remain unclear. In this study, our findings revealed reduced tissues cells, leading to increased proliferating cell nuclear antigen (PCNA) stability through upregulating NEDD8 promote Mechanistically, reduction upregulated...
Tetramethylpyrazine (TMPZ) is one of the active compounds extracted from traditional Chinese medicinal herb Chuanxiong and several studies have shown it to possess anticancer properties. However, its effectiveness in gastric cancer cellular mechanisms are relatively unknown. The present study aimed investigate effect TMPZ on SGC7901 cells, was demonstrated that a high dose inhibited cell viability induced apoptosis by stimulating AMP-activated protein kinase (AMPK) through generation...
Human HLA-F adjacent transcript 10 (FAT10) is a member of the ubiquitin-like-modifier family proteins, which have been implicated in cancer development. In addition, Survivin protein promotes proliferation bladder (BC). this study, we explored link between FAT10 and Survivin. expression was dramatically up-regulated BC tissue samples, Kaplan-Meier survival analysis revealed that patients with high had shorter overall than those low expression. Moreover, RNAi-mediated knockdown decreased...
Recently, studies on transcriptome–proteome relationships have revealed mRNA/protein expression discordance for certain genes and speculated that protein posttranslational modification (PTM) may be involved. However, there is currently no evidence to support this hypothesis. Wnt‐induced secreted protein‐1 (WISP1) the downstream target gene of β‐catenin plays an important role in tumorigenesis progression, but WISP1 different tumor types are controversial. Here, we first confirmed was...
Rho‐associated kinase 2 (Rock2) is known to promote tumorigenesis in hepatocellular carcinoma (HCC). CCAAT/enhancer‐binding protein delta (CEBPD) functions as a tumor suppressor. In this study, we found that the expression of Rock2 and CEBPD are inversely correlated. Knockdown increased inhibited proliferation HCC cells vitro vivo. Mechanistically, regulates through p‐GSK3β/β‐catenin pathway. Taken together, identified novel Rock2–p‐GSK3β/β‐catenin–CEBPD regulatory circuitry, dysfunction...
Homeobox B9 (HOXB9) is proposed to be involved in tumor angiogenesis and metastasis. We investigated the role of HOXB9 progression colon cancer.HOXB9 expression was by immunohistochemically Western blotting 128 cancer patients results were analyzed statistically associated with clinicopathological data survival patients. The effect on cell invasion metastases abilities vitro vivo.HOXB9 overexpressed tissues significantly correlated metastasis poor (P<0.05, respectively). Additionally, high...