A5001077267- Cancer-related molecular mechanisms research
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- RNA modifications and cancer
- Neonatal and Maternal Infections
- Congenital heart defects research
- Circular RNAs in diseases
- Streptococcal Infections and Treatments
- FOXO transcription factor regulation
- Cardiomyopathy and Myosin Studies
- Wnt/β-catenin signaling in development and cancer
- Hemophilia Treatment and Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Immune cells in cancer
- Bacterial Infections and Vaccines
- Kruppel-like factors research
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Cardiovascular Effects of Exercise
- Vitamin K Research Studies
- Immune Cell Function and Interaction
- Biochemical and Molecular Research
Shanghai Jiao Tong University
2013-2025
Shanghai Children's Medical Center
2014-2025
Washington University in St. Louis
2023-2025
Nanjing University
2012-2024
Northwest University
2019-2024
Southern California Clinical and Translational Science Institute
2024
University of Minnesota
2011-2024
Ministry of Education of the People's Republic of China
2020-2024
Henan University of Science and Technology
2016-2024
Ruijin Hospital
2024
Colorectal cancer (CRC), a prevalent malignant tumor of the digestive system, ranks as third and second in global incidence mortality, respectively, 2020, with 1.93 million new cases (≈10% all cancers). There are 940,000 deaths (≈9.4% cancers), CRC younger patients (under 50 years age) has become trend. The pathogenesis is primarily attributed to series genetic epigenetic abnormalities within normal colonic epithelial cells, coupled reshaping microenvironment surrounding stroma. This process...
Cell loss due to apoptosis induced by oxidative stress is a major hurdle for endothelial progenitor cells (EPCs)‐based therapy. Sirtuin 1 (SIRT1) plays important roles in many pathophysiological processes deacetylating various substrates, including forkhead transcription factor (FOXO). However, after deacetylation, the fate of FOXO protein remains be explored. In present study, we investigated whether SIRT1 exerted protective effect on hydrogen peroxide (H 2 O )‐induced EPCs and, if so, what...
Colorectal cancer (CRC) is one of the most common malignant carcinomas in world, and metastasis main cause CRC-related death. However, molecular network involved CRC remains poorly understood. Long noncoding RNA (lncRNA) plays a vital role tumorigenesis may act as competing endogenous (ceRNA) to affect expression mRNA by suppressing miRNA function. In this study, we identified 628 mRNAs, 144 lncRNAs, 25 miRNAs that are differentially expressed (DE) metastatic patients compared with...
// Bin Guo 1, * , Leilei Li Jiapei Aidong Liu 1 Jinghua Wu Haixin Wang 3 Jun Shi Dequan Pang and Qing Cao 2 North China University of Science Technology Affiliated Hospital, Tangshan, Hebei, Hebei Medical Second Shijiazhuang, Hospital Traditional Chinese Medicine Tangshan City, These authors contributed equally to this work Correspondence to: Wu, email: tswujinghua@163.com Keywords: hepatocellular carcinoma, M2 tumor-associated macrophages, interleukin-17, chaperone-mediated autophagy,...
Abstract Integral membrane proteins (IMPs) are pivotal for cellular functions but challenging to investigate. Here, IC‐FPOMP (in‐cell fast photochemical oxidation of MPs) is introduced, a method enabling in situ footprinting IMPs within live cells. generates reactive oxygen radicals from various precursors (TiO 2 nanoparticles or H O ) near the membrane. Leveraging laser and 96‐well plate platform, high‐throughput rapid achieved. two human (human glucose transporter‐hGLUT1 gamma‐glutamyl...
Abstract Integral membrane proteins (IMPs) are pivotal for cellular functions but challenging to investigate. Here, IC‐FPOMP (in‐cell fast photochemical oxidation of MPs) is introduced, a method enabling in situ footprinting IMPs within live cells. generates reactive oxygen radicals from various precursors (TiO 2 nanoparticles or H O ) near the membrane. Leveraging laser and 96‐well plate platform, high‐throughput rapid achieved. two human (human glucose transporter‐hGLUT1 gamma‐glutamyl...
Although circulating histones were demonstrated as major mediators of death in septic mice models, their roles patients are not clarified. The present study sought to evaluate the clinical relevance histone levels children, and antagonizing effects heparin on histones. Histone plasma children significantly higher than healthy controls, positively correlated with disease severity. treatment could activate NF-κB pathway endothelial cells induce secretion large amount cytokines that further...
Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin (SIRT1) affect cellular NAD+ levels play essential roles regulating metabolism. However, there has been little research on the effects of PARP1 SIRT1 crosstalk during senescence. We isolated endothelial progenitor cells (EPCs) from human umbilical cord blood treated them with inhibitor (PJ34). Using stress-induced premature aging model...
The interleukin (IL)-17/IL-17 receptor (IL-17R) complex has been shown to be important for the regulation of inflammation; however, its role in tumor processes recently emerged as a research focus. present study demonstrated that oxaliplatin was able increase levels IL‑17/IL‑17R hepatocellular carcinoma (HCC) patients and cells lines, it had roles reducing susceptibility oxaliplatin‑induced apoptosis. Furthermore, expression autophagy‑related proteins induced by IL-17/IL-17R autophagy induce...
Endothelial‐mesenchymal transition (EndMT) plays a pivotal role in organ fibrosis. This study examined the effect of SIRT1 on transforming growth factor beta (TGF‐β)‐induced EndMT human endothelial cells (ECs) and its probable molecular mechanism. We assessed by immunofluorescence staining, quantitative real‐time polymerase chain reaction, Western blotting, migration invasion assays. Adenovirus was used to overexpress or knockdown ECs. The regulatory relationship between Smad4 analyzed...
Lung cancer is the most common worldwide, and metastasis leading cause of lung related death. However, molecular network involved in remains incompletely described. Here, we aimed to construct a metastasis-associated ceRNA identify lncRNA prognostic signature cancer.RNA expression profiles were downloaded from The Cancer Genome Atlas (TCGA) database. Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses gene set enrichment analysis (GSEA) performed investigate function...
To investigate the mechanism of chaperone-mediated autophagy (CMA)-induced resistance to irradiation-triggered apoptosis through regulation p53 protein in hepatocellular carcinoma (HCC).Firstly, we detected expression lysosome-associated membrane 2a (Lamp-2a), which is key CMA, by western blot HepG2 and SMMC7721 cells after irradiation. We further used shRNA Lamp-2a HCC verify radioresistance induced CMA. Next, HMGB1 irradiation blot, RNA interference ethyl pyruvate (EP), as a inhibitor,...
Clustered regularly interspaced palindromic repeats (CRISPR) and their associated cas genes have been demonstrated to regulate self-genes virulence in many pathogens. In this study, we found that inactivation of cas9 caused reduced adhesion intracellular survival the piscine Streptococcus agalactiae strain GD201008-001 significantly decreased zebrafish mice. Further investigation indicated regR transcriptional regulator was upregulated Δcas9 mutant. As mediates repression hyaluronidase, a...