A5100383996- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Infection Control and Ventilation
- Microbial Natural Products and Biosynthesis
- Galectins and Cancer Biology
- Chromosomal and Genetic Variations
- Hepatitis C virus research
- Glycosylation and Glycoproteins Research
- Marine Sponges and Natural Products
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Airway Management and Intubation Techniques
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- COVID-19 and healthcare impacts
- Synthetic Organic Chemistry Methods
- Tracheal and airway disorders
- Acute Myocardial Infarction Research
- Phytochemical compounds biological activities
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Respiratory Support and Mechanisms
Kunming Institute of Zoology
2019-2025
Chinese Academy of Sciences
2019-2025
Tianjin University
2024-2025
University of Hong Kong
2019-2025
China National Research Institute of Food and Fermentation
2025
Ministry of Agriculture and Rural Affairs
2025
Henan Agricultural University
2025
Henan University of Science and Technology
2025
Xi'an University of Science and Technology
2025
Peking University
2021-2024
The coronavirus disease 2019 (COVID-19) pandemic has led to a major shortage of N95 respirators, which are essential for protecting healthcare professionals and the general public who may come into contact with virus. Thus, it is determine how we can reuse respirators other personal protective equipment in these urgent times. We investigated multiple commonly used disinfection schemes on media particle filtration efficiency 95%. Heating was recently found inactivate virus solution within 5...
The COVID-19 pandemic is currently causing a severe disruption and shortage in the global supply chain of necessary personal protective equipment (e.g., N95 respirators). U.S. CDC has recommended use household cloth by general public to make face coverings as method source control. We evaluated filtration properties natural synthetic materials using modified procedure for respirator approval. Common fabrics cotton, polyester, nylon, silk had efficiency 5–25%, polypropylene spunbond 6–10%,...
Adaptation to reduced energy production during aging is a fundamental issue for maintaining healthspan or prolonging life span. Currently, however, the underlying mechanism in long-lived people remains poorly understood. Here, we analyzed transcriptomes of 185 individuals (LLIs) and 86 spouses their children from two independent Chinese longevity cohorts found that ribosome pathway was significantly down-regulated LLIs. We down-regulation likely controlled by ETS1 (ETS proto-oncogene 1),...
Background Radiomics has been applied for assessing lymphovascular invasion (LVI) in patients with breast cancer. However, associations between features from peritumoral regions and the LVI status were not investigated. Purpose To investigate value of intra‐ radiomics LVI, to develop a nomogram assist making treatment decisions. Study Type Retrospective. Population Three hundred sixteen enrolled two centers divided into training ( N = 165), internal validation 83), external 68) cohorts....
Apiose is a natural pentose containing an unusual branched-chain structure. Apiosides are bioactive products widely present in the plant kingdom. However, little known on key apiosylation reaction biosynthetic pathways of apiosides. In this work, we discover apiosyltransferase GuApiGT from Glycyrrhiza uralensis. could efficiently catalyze 2″-O-apiosylation flavonoid glycosides, and exhibits strict selectivity towards UDP-apiose. We further solve crystal structure GuApiGT, determine...
Abstract The transition from ordered to noisy is a significant epigenetic signature of aging and age‐related disease. As paradigm healthy human longevity, long‐lived individuals (LLI, >90 years old) may possess characteristic strategies in coping with the disordered regulation. In this study, we constructed high‐resolution blood noise landscapes for cohort by methylation entropy (ME) method using whole genome bisulfite sequencing (WGBS). Although universal increase global ME occurred...
Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignant cancer in the adrenal cortex with poor prognosis. Though previous research has attempted to elucidate progression of ACC, its molecular mechanism remains poorly understood. Methods Gene transcripts per million (TPM) data were downloaded from UCSC Xena database, which included ACC (The Cancer Genome Atlas, n = 77) normal samples (Genotype Tissue Expression, 128). We used weighted gene co-expression network analysis...
Abstract The current COVID-19 pandemic has highlighted global supply chain shortcomings in the US hospital delivery system, most notably personal protective equipment (PPE) and is found on these masks ∼7 days. Recent work from our group shown two promising disinfection methods for N95 facial masks, dry heat (hot air (75 °C, 30 min) UVGI which 254 nm, 8W, min. Using five models of three different manufacturers we determined following: 1) Hot treated applied over 5 cycles did not degrade fit...
Abstract Background Inflammatory bowel disease (IBD), which includes Crohn’s (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have inconsistent may face bias of confounding reverse causality. The potential causal relationships between IBD risk cancers remain largely unclear. Methods We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR),...
Highlights•WGBS identifies 3,035 differentially methylated genomic units (DMUs) specific to long-lived men•DMUs are preferentially linked genes related aging, age-related disease, and longevity•DMUs have the potential signify methylomic features in comprise CpG sites that rarely covered by methylation microarraysSummaryMen, despite having a lower likelihood of longevity compared women, generally exhibit better health status when they achieve longevity. The role DNA this paradox remains...
Electrocatalytic dehalogenative deuteration is a sustainable method for precise deuteration, whereas its Faradaic efficiency (FE) limited by high overpotential and severe D2 evolution reaction (DER). Here, Cuδ+ site-adjusted adsorption crown ether-reconfigured interfacial D2O are reported to cooperatively increase the FE of up 84% at −100 mA cm–2. sites strengthen aryl iodides, promoting mass transfer thus accelerating kinetics toward deuteration. The ethers disrupt hydration effect K·D2O...
Extracellular vesicles (EVs) are important paracrine mediators derived from various cells and biological fluids, including plasma, that capable of inducing regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This study investigated the effect mesenchymal stem cell-derived extracellular (MSC-EVs) isolated umbilical cord blood human plasma-derived (UCB-EVs) on wound healing scar formation reduction. Spatial transcriptomics (ST) was used to MSC-EVs UCB-EVs...
Probiotics have attracted increasing attention due to their benefits in terms of relieving gastrointestinal ailments, including constipation. This study evaluated the potential Weizmannia coagulans BC99 for clinical remission constipation adults. In this randomized, double-blind, and placebo-controlled trial, 90 individuals with were divided between a placebo group an 8-week intervention duration. The spontaneous bowel movement (SBM) frequency, patient assessment symptoms (PAC-SYM), quality...
The significant demand for medicinal plants with special efficacy has prompted us to adopt appropriate processing methods enhance the nutritional quality and flavor of raw materials. This study evaluated impacts freeze-drying (FD), hot-air drying (HAD), spray (SD) on bioactive compounds, characteristics, inhibition starch digestion in mulberry leaf ethanol extract (MLE). Results indicated that FDMLE exhibited highest total alkaloids content (TAC: 0.14 ± 0.02 mg/g) flavonoid (TFC: 19.32 0.58...
To meet the mining requirements of ’excavation–backfill–retention’ tunneling method for inter-panel coal pillars, this paper proposes an integrated ‘excavation–backfill–retention’ equipment system centered on a cutting robot. An interactive design was employed to analyze interaction between conditions and robot, constructing ’requirements–functions–structure’ model. The robot integrates horizontal drum mechanism with slider shoe walking mechanism, offering enhanced adaptability various...
Histone deacetylases (HDACs) are a class of epigenetic regulators that play pivotal roles in key biological processes such as cell proliferation, differentiation, metabolism, and immune regulation. Based on this, HDAC inhibitors (HDACis), novel epigenetic-targeted therapeutic agents, have demonstrated significant antitumor potential by inducing cycle arrest, activating apoptosis, modulating the microenvironment. Current research is focused developing highly selective isoform combination...
MicroRNAs (miRNAs) are fast evolving endogenous small RNAs that regulate organism function and behavior in both animals plants. Although models for de novo miRNA biogenesis have been proposed, the genomic mechanisms driving swift diversification of repertoires plants remain elusive. Here, by comprehensively analyzing 21 phylogenetically representative plant species, ranging from green algae to angiosperms, we systematically identified events associated with 8,649 loci. We found 399 (4.6%),...
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has led to a major shortage of N95 respirators, which are essential protecting healthcare professionals and the general public who may come into contact with virus. Thus, it is determine how we can reuse respirators other personal protection in these urgent times. We investigated multiple commonly used easily deployable, scalable disinfection schemes on media particle filtration efficiency 95%. Among these, heating (≤85 °C) under...
In the field of lower limb exoskeletons, it is essential to accurately estimate gait phase humans. Many methods have been proposed phase, but only a few studies considered multi-locomotion mode. This paper proposes novel inertial measurement unit(IMU)-based method pilot in continuous The includes pattern recognition based on long short-term memory (LSTM), estimation dual adaptive frequency oscillator(DAFO), threshold-based toe-off event detection and rule-based synchronization module. First,...