A5055388471- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Infection Control and Ventilation
- Social Media in Health Education
- COVID-19 and healthcare impacts
- Musculoskeletal pain and rehabilitation
- Cardiac, Anesthesia and Surgical Outcomes
- Health Literacy and Information Accessibility
- Pain Management and Placebo Effect
- Patient-Provider Communication in Healthcare
- Empathy and Medical Education
- Opioid Use Disorder Treatment
- Cardiac Arrest and Resuscitation
- Artificial Intelligence in Healthcare and Education
- COVID-19 epidemiological studies
- Airway Management and Intubation Techniques
- Innovations in Medical Education
- Wikis in Education and Collaboration
- Patient Safety and Medication Errors
- Anesthesia and Sedative Agents
- Spine and Intervertebral Disc Pathology
- Web and Library Services
- Respiratory Support and Mechanisms
- Simulation-Based Education in Healthcare
Stanford University
2015-2025
Stanford Medicine
2007-2022
University of Southern California
2022
Collaborative Research Group
2021
American Institute of Mathematics
2020
Peking University
2020
4C Air (United States)
2020
Stratford University
2020
Foundation for the National Institutes of Health
2017
VA Palo Alto Health Care System
2017
Significance Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) devastates the lives of millions people and has remained a mystery illness despite decades research. It long been suspected that inflammation is central to its pathogenesis. Although only two cytokines were found be different (TGF-β higher resistin lower) in ME/CFS patients compared with controls, 17 correlated severity. Thirteen these are proinflammatory may contribute many symptoms experience for several years. Only...
The science around the use of masks by general public to impede COVID-19 transmission is advancing rapidly. Policymakers need guidance on how should be used population combat pandemic. Here, we synthesize relevant literature inform multiple areas: 1) characteristics COVID-19, 2) filtering and efficacy masks, 3) estimated impacts widespread community mask use, 4) sociological considerations for policies concerning mask-wearing. A primary route likely via small respiratory droplets, known...
The COVID-19 pandemic is currently causing a severe disruption and shortage in the global supply chain of necessary personal protective equipment (e.g., N95 respirators). U.S. CDC has recommended use household cloth by general public to make face coverings as method source control. We evaluated filtration properties natural synthetic materials using modified procedure for respirator approval. Common fabrics cotton, polyester, nylon, silk had efficiency 5–25%, polypropylene spunbond 6–10%,...
Background: Many online physician-rating sites provide patients with information about physicians and allow to rate physicians. Understanding what is available important given that may use this choose a physician.
Chronic opioid exposure is known to produce neuroplastic changes in animals; however, it not if opioids used over short periods of time and at analgesic dosages can similarly change brain structure humans. In this longitudinal, magnetic resonance imaging study, 10 individuals with chronic low back pain were administered oral morphine daily for 1 month. High-resolution anatomical images the acquired immediately before after administration period. Regional gray matter volume assessed on whole...
Most hospital policies prohibiting the use of wireless devices cite reports disruption medical equipment by cellular telephones. There have been no studies to determine whether mobile telephones may a beneficial impact on safety. At 2003 meeting American Society Anesthesiologists 7878 surveys were distributed attendees. The five-question survey polled anesthesiologists regarding modes communication used in operating room/intensive care unit and experience with communications delays errors....
Two constitutive acetyl-CoA acetyltransferases (3-ketothiolases A and B) were purified from Alcaligenes eutrophus. Enzyme was active with only acetoacetyl-CoA 3-ketopentanoyl-CoA, whereas enzyme B all the 3-ketoacyl-CoAs (C4−C10) tested. appeared to be a tetramer (Mr 70 000) identical subunits 44 had similar Mr of 168 000 (containing 46 subunits). Enzymes isoelectric points 5.0 6.4, respectively. The stoichiometry reactions catalysed by each confirmed. Km values μM 394 for acetoacetyl-CoA,...
In Brief BACKGROUND: The use of ketamine in children with increased pulmonary vascular resistance is controversial. this prospective, open label study, we evaluated the hemodynamic responses to hypertension (mean artery pressure >25 mm Hg). METHODS: Children aged 3 mo 18 yr hypertension, who were scheduled for cardiac catheterization general anesthesia, studied. Patients anesthetized sevoflurane (1 minimum alveolar anesthetic concentration [MAC]) air while breathing spontaneously via a...
Applications of machine learning on clinical data are now attaining levels performance that match or exceed human clinicians.1–3 Fields involving image interpretation—radiology, pathology and dermatology—have led the charge due to power convolutional neural networks, existence standard formats large repositories. We have also seen powerful diagnostic predictive algorithms built using a range other data, including electronic health records (EHR), -omics, monitoring signals, insurance claims...
Despite the use of web-based information resources by both anesthesia departments and applicants, little research has been done to assess these determine whether they are meeting applicant needs. Evidence is needed guide informatics in developing high-quality residency program Web sites (ARPWs).We used an anonymous (SurveyMonkey, Portland, OR) distribute a survey investigating needs perceived usefulness ARPWs all 572 Stanford applicants. A quantitative scoring system was then created quality...
Summary After 1 month of oral morphine therapy, chronic low-back pain patients developed tolerance but not opioid-induced hyperalgesia. Improvements in and functional ability were observed. Although often successful acute settings, long-term use opioid medications may be accompanied by waning levels analgesic response readily attributable to advancing underlying disease, necessitating dose escalation attain relief. Analgesic tolerance, more recently hyperalgesia, have been invoked explain...
Using their experience at Medicine X, Larry Chu and colleagues discuss the benefits of involving patients as partners medical meetings
The science around the use of masks by general public to impede COVID-19 transmission is advancing rapidly. Policymakers need guidance on how should be used population combat pandemic. In this narrative review, we develop an analytical framework examine mask usage, considering and synthesizing relevant literature inform multiple areas: impact; characteristics; source control; PPE; sociological considerations; implementation considerations. A primary route via respiratory droplets, known...
According to Dede Bonner in 2000, employees hold a wealth of knowledge and experience about their companies, including the products, customers, internal processes, histories, technologies, competitors. But this is usually dispersed across scattered individuals locations. Although learning happens at an individual level, it as one-time event, without organizational context or sense continuity. Knowledge kept people's minds but not shared organization. Not until 20th century did people start...
Abstract Background Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by persistent that not alleviated rest. The lack of clearly identified underlying mechanism has hindered the development effective treatments. Studies have demonstrated elevated levels inflammatory factors in patients with CFS, but findings are contradictory across studies and no biomarkers been consistently supported. Single time-point approaches potentially overlook important features such as...
The science around the use of masks by general public to impede COVID-19 transmission is advancing rapidly. Policymakers need guidance on how should be used population combat pandemic. In this narrative review, we develop an analytical framework examine mask usage, considering and synthesizing relevant literature inform multiple areas: impact; characteristics; source control; PPE; sociological considerations; implementation considerations. A primary route via respiratory droplets, known...
Abstract The current COVID-19 pandemic has highlighted global supply chain shortcomings in the US hospital delivery system, most notably personal protective equipment (PPE) and is found on these masks ∼7 days. Recent work from our group shown two promising disinfection methods for N95 facial masks, dry heat (hot air (75 °C, 30 min) UVGI which 254 nm, 8W, min. Using five models of three different manufacturers we determined following: 1) Hot treated applied over 5 cycles did not degrade fit...
In Brief BACKGROUND: A single-dose of neuraxial morphine sulfate provides good post-Cesarean analgesia; however, its efficacy is limited to the first postoperative day. a recent phase III study, extended-release epidural (EREM) formulation provided more effective, prolonged analgesia after Cesarean delivery, compared conventional morphine. However, study protocol did not allow for use nonsteroidal antiinflammatory drugs, used various analgesics, and monitoring treatment respiratory...
Addiction to opioid narcotics represents a major public health challenge. Animal models of one component addiction, physical dependence, show this trait be highly heritable. The analysis dependence using contemporary in-silico techniques offers an approach discover novel treatments for and addiction.In these experiments, withdrawal behavior in 18 inbred strains mice was assessed. Mice were treated 4 days with escalating doses morphine before the administration naloxone allowing...