A5080553382- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Cutaneous lymphoproliferative disorders research
- Phagocytosis and Immune Regulation
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- CNS Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- T-cell and Retrovirus Studies
- Chronic Myeloid Leukemia Treatments
- Extracellular vesicles in disease
- Innovation and Knowledge Management
- Acute Lymphoblastic Leukemia research
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Multiple and Secondary Primary Cancers
- Monoclonal and Polyclonal Antibodies Research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Business Strategy and Innovation
Jilin University
2016-2025
First Hospital of Jilin University
2016-2025
First Bethune Hospital of Jilin University
2014-2023
Zhejiang A & F University
2007-2023
University of San Francisco
2018-2020
Marymount University
2020
Beijing Institute of Technology
2020
Yokohama National University
2020
Toshiba (Japan)
2020
Jilin Medical University
2010-2013
Abstract Typical and atypical antipsychotic drugs, though both effective, act on different neurotransmitter receptors are dissimilar in some clinical effects side effects. The typical drug haloperidol has been shown to cause a decrease the expression of brain‐derived neurotrophic factor (BDNF), which plays an important role neuronal cell survival, differentiation, connectivity. However, it is still unknown whether drugs similarly regulate BDNF expression. We examined chronic (28 days)...
Exosomes (EXO) derived from dendritic cells (DC), which express major histocompatibility complex (MHC) and costimulatory molecules, have been used for antitumour vaccines. However, they are still less effective by showing only prophylatic immunity in animal models or very limited immune responses clinical trials. In this study, we showed that ovalbumin (OVA) protein-pulsed DC (DC(OVA))-derived EXO (EXO(OVA)) displayed MHC class I-OVA I peptide (pMHC I) complexes, CD11c, CD40, CD80, CCR7,...
Exosomes (EXO) derived from tumour cells have been used to stimulate antitumour immune responses, but only resulting in prophylatic immunity. Tumour-derived heat shock protein 70 (HSP70) molecules are molecular chaperones with a broad repertoire of antigen peptides capable stimulating dendritic cell (DC) maturation and T-cell responses. To enhance EXO-based immunity, we generated an engineered myeloma line J558(HSP) expressing endogenous P1A transgenic form membrane-bound HSP70 heat-shocked...
Abstract Neuroanatomical studies suggest that neuronal atrophy and destruction occur over the course of many years in neurodegenerative conditions such as schizophrenia Alzheimer's disease. In schizophrenia, early intervention with atypical neuroleptics olanzapine has been shown to prevent development some more serious debilitating symptoms patients. The mechanisms whereby slows or prevents symptom progression remain unclear. A previous study found increased mRNA for copper/zinc isoform...
Abstract The traditional chemotherapy, including Adriamycin (Doxorubicin, DOX), is widely used and part of the first-line chemotherapy invasive B cell lymphoma. DOX nonselective cytotoxic drug has many adverse effects, which limit its clinical application in combination with other anti-cancer drugs. Optimization delivery system targeting tumor microenvironment could be a feasible approach that may have significant significance. Further, anticancer drugs, such as curcumin, can enhance...
Hepatocellular carcinoma (HCC) has been increasingly recognized in nonalcoholic steatohepatitis (NASH) patients. Fibroblast growth factor 21 (FGF21) is reported to prevent NASH and delay HCC development. In this study, the effects of FGF21 on progression NASH-HCC transition potential mechanism(s) were investigated.
Abstract Atypical antipsychotic drugs are widely used in the treatment of schizophrenia, and clinical evidence has shown that early prolonged intervention with these will improve long‐term outcome. It is still unclear, however, whether atypical also neuroprotective. To clarify this matter, we PC12 cell cultures MTT assay for viability to determine various concentrations antipsychotics clozapine, quetiapine, risperidone neuroprotective after serum withdrawal. In addition, explore drugs'...
Objectives In this study, the etiology, clinical characteristics, and prognosis of multiple primary malignant tumors (MPMTs) were investigated. Furthermore, we analyzed treatment factors associated with MPMTs. Methods From 15,398 patients presenting to The First Hospital Jilin University, China, between January 2010 December 2013, identified Data obtained retrospectively from hospital database. Results prevalence MPMTs in study was 0.99% (152/15398): 51 cases synchronous MPMTs, 101...
The development of lymphoma is a complex multistep process that integrates numerous experimental findings and clinical data have not yet yielded definitive explanation. Studies oncogenic viruses can help to deepen insight into the pathogenesis lymphoma, identifying associations between are established unidentified should lead cellular pharmacologically targeted antiviral strategies for treating malignant lymphoma. This review focuses on lymphomas associated with hepatitis B C, Epstein-Barr,...
Tumor cell apoptosis induced by radiation therapy results in apoptotic tumor cells and apparition of membrane blebs termed bodies (APB). The immune responses have been extensively studied. However, the role APB modulation is elusive. In this study, we 90% ovabumin-expressing EG7 vitro irradiation (9,000 rad) with a subsequent culture for 9 hours. purified from irradiation-induced supernatant differential ultracentrifugation were vesicles 50 to 90 nm diameter expressed apoptosis-specific...
The aim of this study was to profile the spectrum genetic mutations in acute myeloid leukemia (AML) patients co-occurring with CEBPA double mutation (CEBPAdm). Between January 1, 2012, and June 30, 2017, 553 consecutive de novo AML were screened for mutations. Out these, 81 classified as CEBPAdm analyzed further by a sensitive next-generation sequencing assay 112 candidate genes. Within gene itself, we found 164 most common mutated sites c.936_937insGAG (n = 11/164, 6.71%) c.939_940insAAG...
The multi-center randomized phase 3 NHL-004 study compared etoposide, dexamethasone and pegaspargase (ESA) versus methotrexate, (MESA) regimen, combined with sandwiched radiotherapy, in newly diagnosed early-stage nasal natural killer/T-cell lymphoma (NKTCL). Here we report the long-term outcomes (median follow-up, 64 months) biomarker analysis. 256 eligible patients aged 14-70 years were randomly assigned (1:1) to ESA or MESA arm. 5-year progression-free survival (PFS) rates 80.3% 74.9%...
Primary breast diffuse large B‐cell lymphoma ( PB ‐ DLBCL ) is a rare subtype of with limited data on patterns failure. This multicenter study aimed to define the optimum treatment strategy and failure for patients. We retrospectively reviewed 108 patients from 21 Chinese medical centers. Only localized disease (involvement lymph nodes) were included. After median follow‐up 3.2 years, 32% developed progression or relapse. A continuous pattern relapse was observed, characterized by frequent...
This study applies a resource-based perspective to investigate how competition by informal firms affects innovation in formal China. By analyzing survey data, collected from 1,686 Chinese manufacturing firms, we find that tend increase their rate of when faced with competition. However, firms' access increased global supply chain collaboration mitigates the challenges presented firms. We present implications for future research, practice, and policy-making.
Abstract Background Excess body weight has been found to associate with an increased risk of lymphomas and some metabolic pathways are currently recognized in lymphomagenesis. Bioactive lipid metabolites such as sphingosine-1-phosphate (S1P) have proposed play important role linking obesity lymphomas. However, the underlying mechanism(s) S1P signaling obesity-lymphomagenesis not well addressed. Methods The gene expression sphingosine kinase (SPHK), lymphoma prognosis, production were...