A5036574100- Lymphoma Diagnosis and Treatment
- Wound Healing and Treatments
- Chronic Lymphocytic Leukemia Research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Cutaneous lymphoproliferative disorders research
- Coronary Interventions and Diagnostics
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Long-Term Effects of COVID-19
- Acute Myocardial Infarction Research
- Lung Cancer Treatments and Mutations
- Blood disorders and treatments
- Transgenic Plants and Applications
- Lung Cancer Research Studies
- Periodontal Regeneration and Treatments
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Blood transfusion and management
- Cardiac Imaging and Diagnostics
- Toxin Mechanisms and Immunotoxins
- Inflammasome and immune disorders
- Corneal Surgery and Treatments
Chinese PLA General Hospital
2022-2025
First Hospital of Jilin University
2018-2024
Jilin University
2018-2024
University of Louisville
2021-2024
Wenzhou University
2023
Shandong First Medical University
2019-2022
Southwestern University of Finance and Economics
2022
Union Hospital
2020
Union Hospital
2020
Weatherford College
2019
Inflammatory response and oxidative stress are considered to play an important role in the development of acute liver injury induced by carbon tetrachloride (CCl4) galactosamine (GalN)/lipopolysaccharides (LPS). Esculentoside A (EsA), isolated from Chinese herb phytolacca esculenta, has effect modulating immune response, cell proliferation apoptosis as well anti-inflammatory effects. The present study is evaluate protective EsA on CCl4 GalN/LPS-induced injury. In vitro, CCK-8 assays showed...
Abstract This study evaluated the protective effects of inhibiting caspase-1 activity or gastric acid secretion on acute injury in mice. AC-YVAD-CMK, omeprazole, vehicle were administered to mice before cold-restraint stress- ethanol-induced injury. Survival rates and histological evidence pretreated with AC-YVAD-CMK omeprazole exposed stress, improved significantly relative group. The increased levels tumour necrosis factor-α, interleukin (IL)-1β, IL-6 IL-18 following cold-stress decreased...
Abstract Background Excess body weight has been found to associate with an increased risk of lymphomas and some metabolic pathways are currently recognized in lymphomagenesis. Bioactive lipid metabolites such as sphingosine-1-phosphate (S1P) have proposed play important role linking obesity lymphomas. However, the underlying mechanism(s) S1P signaling obesity-lymphomagenesis not well addressed. Methods The gene expression sphingosine kinase (SPHK), lymphoma prognosis, production were...
CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form (soluble CD74, sCD74) was recently discovered autoimmune liver disease. Using two murine ALI models cells culture, we examined presence sCD74 circulation alveolar space preliminarily assessed biological function sCD74. The concentrations were increased serum bronchoalveolar lavage fluids...
To assess the potential benefit of chidamide maintenance therapy after induction treatment in peripheral T-cell lymphoma (PTCL).The clinical data 48 transplantation-ineligible patients with different PTCL subtypes who received continuous first-line were collected. Progression-free survival (PFS), overall (OS), and safety analyzed.In total, 68.8% male (33/48), median age was 59.5 years (22~80). The pathological angioimmunoblastic (AITL, 43.8%), anaplastic large cell (ALCL, 16.6%), PTCL-not...
To conduct a large cross-sectional survey of the mental health college students during recovery period COVID-19 epidemic.Symptom Checklist 90 (SCL-90) and questionnaire were used to investigate overall level cognition epidemic situation in seven colleges universities Shaanxi Province.(1) In epidemic, still had psychological somatic symptoms such as obsessive-compulsive disorder, interpersonal sensitivity, anxiety, hostility, poor appetite or insomnia; (2) female students, science engineering...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a poor prognosis. PDAC has response to immunotherapy because of its unique tumour microenvironment (TME). In attempt stimulate immunologically silent pancreatic cancer, we investigated the role epigenetic therapy in modulating TME improve immunogenicity.In vitro human cell lines MiaPaca2 and S2-013 were treated 5μ m 3-Deazaneplanocin A (DZNep, EZH2 inhibitor) 5 μ 5-Azacytidine (5-AZA, DNMT1 inhibitor). vivo orthotopic...
Background: Cardiac injury and coagulation disorders have been two increasing concerns in the management of patients with severe coronavirus disease (COVID-19). Coagulation COVID-19 cardiac not characterized. Methods: We analyzed data five who had D-dimer surge (defined as a rapid increase level 72 h, from <5–21 μg/mL) during hospitalization, which were extracted registered retrospective study (ChiCTR2000031301). Clinical on changes parameters collected, verified, Results: Among these...
Background: Nonalcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease (NAFLD) and a potential precursor hepatocellular carcinoma (HCC).In our previous studies, we found that endocrine fibroblast growth factor 21 (FGF21) played key role in preventing development NASH, however, FGF15/19 mediated-FGFR4 signaling worsened NASH even contributed to NASH-HCC transition.The aim this study determine whether FGF15/FGFR4 could alleviate or aggravate FGF21KO...
Porphyromonas gingivalis , a keystone periodontal pathogen, has emerged as risk factor for systemic chronic diseases, including non-alcoholic fatty liver disease (NAFLD). To clarify the mechanism by which this pathogen induces such we simultaneously analyzed transcriptome of intracellular P. and infected host cells via dual RNA sequencing. Pathway analysis was also performed to determine differentially expressed genes in cells. Further, infection-induced notable expression livk livh genes,...
QT interval prolongation and ventricular arrhythmias (VAs) induced by osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, are life-threatening complications. However, no consensus has been achieved regarding their management. Overdrive pacing shown to be effective in shortening the terminating torsade de pointes (TdP). Here, we report case of osimertinib-induced accompanied frequent VAs TdP. Osimertinib was immediately discontinued after it identified...
Glutamate has been implicated in exercise‐induced fatigue, but the underlying mechanism is unknown. This study aimed to determine whether glutamate transporter‐1 (GLT‐1) a key role regulation of fatigue. The expressions GLT‐1 and glial fibrillary acidic protein (GFAP) supplementary motor area rats exposed exhaustion were analyzed by immunohistochemistry. expression was further confirmed Western blotting. effects on extracellular levels lactate exercise endurance studied microdialysis....
Stress-induced gastric ulcer is an important life-threatening condition, while the molecular basis of its development incompletely understood. Toll-like receptor 4 (TLR4), innate immune pattern recognition receptor, can induce pro-inflammatory transcription, aggravating a stress ulcer. The present study found that TLR4 played protective role in mouse model water immersion (23 °C) restraint stress. Wild-type (WT) and TLR4−/− male mice were respectively divided into five groups (5 per group),...