A5084078831- Dermatology and Skin Diseases
- Genetic and rare skin diseases.
- Skin and Cellular Biology Research
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Fungal Infections and Studies
- Cancer and Skin Lesions
- Dermatological diseases and infestations
- Sympathectomy and Hyperhidrosis Treatments
- Antifungal resistance and susceptibility
- Dermatological and Skeletal Disorders
- Asthma and respiratory diseases
- Structural Health Monitoring Techniques
- melanin and skin pigmentation
- Peptidase Inhibition and Analysis
- Plant Pathogens and Fungal Diseases
- Skin Diseases and Diabetes
- Acne and Rosacea Treatments and Effects
- Insects and Parasite Interactions
- Hedgehog Signaling Pathway Studies
- Ovarian cancer diagnosis and treatment
- Numerical methods in engineering
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cutaneous lymphoproliferative disorders research
Peking University Third Hospital
2024-2025
Peking University
2024-2025
Chinese PLA General Hospital
2022-2025
Shanghai Veterinary Research Institute
2025
Rensselaer Polytechnic Institute
2022-2025
General Hospital of Shenyang Military Region
2025
Guangdong Medical College
2015-2024
Tsinghua University
2024
Chinese People’s Liberation Army 263 hospital
2024
AstraZeneca (United States)
2024
Abstract The symptoms of vaginal candidiasis exacerbate in the second half menstrual cycle premenopausal women when serum estradiol level is elevated. Estradiol has been shown to inhibit Th17 differentiation and production antifungal IL-17 cytokines. However, little known about mechanisms. In present study, we used mouse splenocytes found that inhibited through downregulation Rorγt mRNA protein expression. activated estrogen receptor (ER)α recruit repressor activity (REA) form ERα/REA...
Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed in liver and adipocytes, plays key roles endobiotic homeostasis xenobiotic metabolism. This study aimed to find potent selective inhibitors against hCE1 from phytochemicals their derivatives. To this end, a series natural triterpenoids were collected inhibitory effects human carboxylesterases (hCEs) assayed using D-Luciferin methyl ester (DME) 6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl...
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical staining showed that is predominantly expressed basal layer normal human skin epidermis, highly several diseases including psoriasis, cell carcinoma, keratoacanthoma squamous carcinoma. calcium-induced keratinocyte differentiation model, was decreased a time dependent manner. When overexpressed using recombinant adenovirus, growth enhanced, while differentiation-related...
Peanut pod rot is one of the major plant diseases affecting peanut production and quality over China, which causes large productivity losses challenging to control. To improve disease resistance peanuts, breeding significant strategy. Crucial preventative management measures include grading screening high-contributed genes that are highly resistant should be carried out. A machine vision-based approach for individual cases was proposed in this study, avoids time-consuming, labor-intensive,...
Abstract Forkhead box‐O1 (FoxO1) is a key nutrient‐ and growth factor‐dependent regulator of metabolism, but its functional role in human primary keratinocytes ( HPK s) less known. To investigate the FoxO1 s effect insulin‐like factor 1 IGF ‐1) isotretinoin on expression, were treated with 1.2 mmol/L calcium chloride, 1‐20 ng/mL ‐1 0.1‐10 μmol/L isotretinoin. Recombinant adenovirus expressing or FKHR sh RNA lentivirus transfection was introduced to upregulate silence expression. Epidermal...
The synthesis of materials has been an important task throughout human history, and the ability to perform successful efficient syntheses a factor in industrial revolutions societal development. Recently, rapid development sophisticated techniques such as flow methods, artificial intelligence, information technology, robotics, facilitated autonomous chemicals with minimal effort at little cost economy. This trend influenced recent research could potentially reduce time from discovery their...
Tree height is an essential indicator in forestry research. This difficult to measure directly, as well wind disturbance adds the measurement difficulty. Therefore, tree has always been issue that experts and scholars strive improve. We propose a method based on fisheye images improve accuracy of measurements. Our aim extract extreme points by proposing improved lightweight target detection network YOLOX-tiny. added CBAM attention mechanism, transfer learning, data enhancement methods recall...
<title>Abstract</title> <bold>Background:</bold> The coexistence of spinal degenerative diseases and hip joint degeneration is common among middle-aged elderly individuals, causing significant suffering economic burden for patients. Total arthroplasty (THA) lumbar fusion (LF) are primary treatment options this combined condition, but the impact surgical sequence on patient outcomes remains unclear. Hence, study aims to evaluate effects THA LF symptom recovery, changes in sagittal...
The coexistence of spinal degenerative diseases and hip joint degeneration is common among middle-aged elderly individuals, causing significant suffering economic burden for patients. Total arthroplasty (THA) lumbar fusion (LF) are primary treatment options this combined condition, but the impact surgical sequence on patient outcomes remains unclear. Hence, study aims to evaluate effects THA LF symptom recovery, changes in sagittal spine-pelvis parameters, incidence long-term complications A...
Toxoplasma gondii is an obligate intracellular parasite that stimulates production of high levels proinflammatory cytokines, which are important for innate immunity. NLRs, i.e., nucleotide-binding oligomerization domain (NOD)-like receptors, play a crucial role as immune sensors and form multiprotein complexes called inflammasomes, mediate caspase-1-dependent processing pro-IL-1β. To elucidate the inflammasome components in T. gondii-infected THP-1 macrophages, we examined...
Autophagy and apoptosis are critical for controlling Toxoplasma gondii (T. gondii) infection. T. infection during pregnancy can damage the fetus cause birth defects; however, molecular mechanisms of this process poorly understood. This study aims to determine activities autophagy as well their regulatory by using human umbilical cord mesenchymal stem cells (hUC-MSCs) a model congenital diseases. LC3B, hallmark protein was incrementally upregulated with duration, whereas p62 downregulated in...