A5100324222- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- EEG and Brain-Computer Interfaces
- Epigenetics and DNA Methylation
- Acupuncture Treatment Research Studies
- Genetic Associations and Epidemiology
- Nerve injury and regeneration
- Plant-based Medicinal Research
- Transcranial Magnetic Stimulation Studies
- Nutrition, Genetics, and Disease
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Pain Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Neuroscience and Neural Engineering
- Inflammatory Bowel Disease
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Immune cells in cancer
- Immune Response and Inflammation
Beijing Proteome Research Center
2024
Hubei University of Chinese Medicine
2024
Shenzhen Institutes of Advanced Technology
2022-2024
Chinese Academy of Sciences
2024
Beijing Forestry University
2024
Ruijin Hospital
2023-2024
Neijiang Normal University
2024
Beijing University of Chinese Medicine
2017-2023
Guizhou Provincial People's Hospital
2023
Harbin Medical University
2013-2023
Abstract Background Inflammatory bowel disease (IBD), which includes Crohn’s (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have inconsistent may face bias of confounding reverse causality. The potential causal relationships between IBD risk cancers remain largely unclear. Methods We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR),...
Background The number of patients with Alzheimer’s disease (AD) worldwide is increasing yearly, but the existing treatment methods have poor efficacy. Transcranial alternating current stimulation (tACS) a new for AD, offline effect tACS insufficient. To prolong effect, we designed to combine sound maintain long-term post-effect. Materials and explore safety effectiveness combined its impact on cognition AD patients. This trial will recruit 87 mild moderate AD. All were randomly divided into...
Electroconvulsive shock (ECS) is utilized to treat depression but may cause learning/memory impairments, which be ameliorated by anesthetics through the modulation of hippocampal synaptic plasticity. Given that plasticity governed aerobic glycolysis, it remains unclear whether modulate glycolysis enhance learning and memory function. Depression-like behavior in rats was induced chronic mild unpredictable stress (CUMS), with anhedonia assessed via sucrose preference test (SPT)....
本研究对儿童肠道健康与整体健康之间的关系进行了整理并提出其干预策略。肠道微生物群在儿童生长发育、免疫系统发育和神经系统发育中起着至关重要的作用。营养不良、抗生素滥用和环境污染等因素对儿童肠道健康产生负面影响，可能导致肥胖、过敏性疾病和神经发育障碍等问题。通过合理饮食、益生菌和益生元补充以及生活方式调整等干预策略，可以有效改善儿童肠道健康，从而促进其整体健康发展。本文旨在为儿童肠道健康研究提供理论依据，并为相关干预措施的制定提供参考。
Microglia cells are the macrophage population within central nervous system, which acts as first line of immune defense. These present a high level heterogeneity among different brain regions regarding morphology, cell density, transcriptomes, and expression inflammatory mediators. This region-specific may lead to neuroinflammatory responses, influencing regional involvement in several neurodegenerative diseases. In this study, we aimed evaluate microglial response 16 regions. We compared...
The expression and regulatory mechanism of NSUN6 in lung cancer are still unclear. Our study explored whether mediates progression by affecting NM23-H1 an m5C-dependent manner.
The cholinergic anti-inflammatory pathway (CAP) has a strong effect on collagen-induced arthritis (CIA), classic animal model of rheumatoid (RA). However, the underlying immune regulatory mechanism remains unclear. Here, we investigated CAP development and involvement dendritic cells (DCs). Forty DBA/1 mice were randomly divided into five groups: control group (sham vagotomy+ phosphate-buffered saline; shamVGX+PBS), CIA (shamVGX+CIA + PBS), vagotomy (VGX GTS-21 (4 mg/kg) GTS-4), (8 GTS-8)....
Transcranial alternating current stimulation (tACS) is a relatively new non-invasive brain electrical method for the treatment of patients with Alzheimer's disease (AD), but it has poor offline effects. Therefore, we applied combined to observe effect on cognitive function AD. Here, describe clinical results case in which tACS sound was treat moderate The patient 73-year-old woman 2-year history persistent deterioration despite administration Aricept and Sodium Oligomannate. received...
Breast tumor kinase (Brk), also known as protein tyrosine 6, is a nonreceptor containing SH3, SH2, and catalytic domains. Brk upregulation oncogenic properties have been found in several malignant tumors, including breast, colon carcinomas, melanomas, but the expression of its clinical significance non-small cell lung cancer (NSCLC) remains unclear. In current study, we examined correlation with clinicopathological features involving p53, ki67, E-cadherin status NSCLC tissue using...
Tuina can effectively alleviate ulcerative colitis-related symptoms, but the mechanism of action is unknown. The purpose this research to explore potential pathways for treatment tuina through gut microbiota and proteomics techniques. Thirty-two male BALB/c mice were divided into four groups, control, model, mesalazine, groups. colitis model was established by freely drinking a 3% dextran sulphate sodium solution 7 days. mesalazine group group, respectively, received days treatment....
Previous studies have proved and investigated the mechanism of analgesic effect tuina treatment on neuropathic pain. The purpose this study was to analyze changes in gene expression dorsal root ganglia (DRG) spinal horn (SDH) after 1-time intervention investigate immediate by tuina. An improvement nociceptive behavior minor chronic constriction injury (CCI) rats observed. more effective amelioration thermal hyperalgesia, but no were found ultrastructure DRG SDH. Sixty-five differentially...
To evaluate the effectiveness and safety of Shenfu injection (SFI) combined with standard bundle treatment in septic patients hypoperfusion.
Tumor-associated macrophages (TAMs) are key regulators in tumor progression, but the precise role of bone marrow-derived monocytes (Mons) as TAM precursors and their dynamic phenotypes regulated by microenvironment (TME) remain unclear. Here, we developed an optimized microproteomics workflow to analyze low-cell-number mouse myeloid cells. We sorted TAMs corresponding Mons (1 × 105 per sample) from individual melanoma models at both early late stages. established protein expression profiles...
Rationale: Ramsay Hunt syndrome in conjunction with cranial polyneuritis is not extensively documented, and very easily misdiagnosed. Patient concerns: A case of a 53-year-old male presented early symptoms vertigo, cephalalgia, facial palsy, followed by zoster oticus 10 days later. Diagnoses: Diagnosis was challenging as this condition presents multiple neuropathies, attempting to diagnose based on clinical often misleading. Polymerase chain reaction can be used test for presence the virus...